Debug Stats | ### Total Build Time: 35 ms 38.849 KB CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 360 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 299 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 553 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.502 KBCONCEPT_RELATIONSHIPS gt=10 ms Completed: 10 ms rowSize= 15.738 KBCONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 19.042 KBCONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.165 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Relationships (72)
Relation Types: diso_to_anat : 21 diso_to_chem : 9 diso_to_diso : 34 diso_to_gene : 1 diso_to_phen : 6 diso_to_phys : 1
Relationships: none : 30 clinically_similar : 1 is_abnormal_cell_of_disease : 9 is_finding_of_disease : 3 is_normal_cell_origin_of_disease : 3 is_normal_tissue_origin_of_disease : 2 is_not_abnormal_cell_of_disease : 1 is_not_finding_of_disease : 3 is_not_normal_cell_origin_of_disease : 1 is_primary_anatomic_site_of_disease : 2 isa : 7 may_be_associated_disease_of_disease : 1 may_be_finding_of_disease : 5 may_treat : 3 sort_version_of : 1 | |
DISO_to_PHEN | 72 | |
genetic aspects C0017399 | DISO_to_DISO | 39 | |
Complication Aspects C1171258 | DISO_to_PHEN | 39 | |
genetic aspects C0017399 | DISO_to_DISO | 19 | |
Complication Aspects C1171258 | DISO_to_DISO | 18 | |
Chromosomal translocation C0040715 | DISO_to_DISO | 18 | |
Chromosome Inversion C0021943 | DISO_to_CHEM | 17 | |
Chimeric Oncogene Proteins C0029014 | DISO_to_CHEM | 16 | |
TRANSCRIPTION FACTOR C0040648 | DISO_to_ANAT | 15 | |
16 chromosome C0008658 | DISO_to_DISO | 13 | |
Dysmyelopoietic Syndromes C0026986 | DISO_to_CHEM | 11 | |
Binding Protein, DNA C0012940 | DISO_to_DISO | 11 | |
Acute monocytic leukemia C0023465 | DISO_to_DISO | 11 | |
Chromosomal translocation C0040715 | DISO_to_DISO | 11 | |
Leukemia, Myelocytic, Acute C0023467 | DISO_to_DISO | 11 | |
Precursor Cell Lymphoblastic Leukemia Lymphoma C1961102 | DISO_to_DISO | 10 | |
CMML C0023480 | DISO_to_DISO | 9 | |
Leukemia, Myelocytic, Acute C0023467 | DISO_to_ANAT | 8 | |
Chromosome 11 C0008653 | DISO_to_DISO | 8 | |
Infiltration, Leukemic C0162679 | DISO_to_CHEM | 7 | |
Antineoplastic Agents C0003392 | DISO_to_GENE | 7 | |
Cellular Oncogene C0033713 | DISO_to_ANAT | 6 | |
In Blood C0005768 | DISO_to_DISO | 6 | |
Graft vs Host Disease C0018133 | DISO_to_CHEM | 5 | |
Chimeric Oncogene Proteins C0029014 | DISO_to_CHEM | 5 | |
Granulocyte Colony-Stimulating Factor C0079459 |
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Genes (10)
Species: human : 10 | |
Human | MLLT11 | 10962 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | We have characterized two t(1;11)(q21;q23) translocations that fuse the MLL gene to a novel gene, AF1q on chromosomal band 1q21, in two infants with acute myelomonocytic leukemia (AMMOL). | Human | SEPT9 | 10801 | septin 9 | Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25). | Human | TCL1A | 8115 | T-cell leukemia/lymphoma 1A | TCL1 was also expressed in myelomonocytic blasts of 3 transformed BT cases but not in true NK-cell tumors (n = 18), de novo acute myelomonocytic leukemias (1 of 14, 7%), or mature T-cell malignancies (1 of 112, < 1%), with the exception of T-prolymphocytic leukemia (T-PLL). | Human | MYH11 | 4629 | myosin, heavy chain 11, smooth muscle | These results correct a recent assignment of MYH11 from 16q12.2 to the region of the 16p-arm inversion breakpoint seen in acute myelomonocytic leukemia (AMML) M4Eo and demonstrate that the conflicting data do not result from the presence of additional MYH genes on the q arm of the chromosome. Detection of the PEBP2beta/MYH11 fusion transcript in acute myelomonoblastic leukemia (M4Eo) supervening in a patient with adult T-cell leukemia. [Detection of PEBP2 beta/MYH11 fusion mRNA in acute myelomonocytic leukemia without marrow eosinophilia] METHODS: Spectrum red labeled yeast artificial chromosome (YAC) clone 854E2 which spans the breakpoint cluster region in MYH11 in band 16p13 and single color interphase FISH were used to detect inv (16) in 26 cases of acute myelomonocytic leukemias (AML-M(4)), and the results were compared with that of conventional cytogenetic analysis. We present here a case of acute myeloid leukemia M4 with eosinophilia (AML-M4Eo) positive for the CBFb/MYH11 rearrangement and carrying a t(1;12)(q25;p13) that involves the ETV6 gene at 12p13. METHODS: Spectrum red labeled yeast artificial chromosome (YAC) clone 854E2 which spans the breakpoint cluster region in MYH11 in band 16p13 and single color interphase FISH were used to detect inv (16) in 26 cases of acute myelomonocytic leukemias (AML-M(4)), and the results were compared with that of conventional cytogenetic analysis. Acute myelomonoblastic leukemia carrying the PEBP2beta/MYH11 fusion gene. [Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] To study the clinical significance of the detection of inv(16) (p13 q22) by FISH in the diagnosis and prognosis for M(4), the metaphase bone marrow cells of 6 cases M(4) which had already diagnosed by morphology were detected for CBFbeta-MYH(11) fusion gene by MYH 11 probe including dual labelled sequences and the results were compared with that of conventional cytogenetic analysis. | Human | CSF1R | 1436 | colony stimulating factor 1 receptor | In this study, RNA from 24 human acute myelomonocytic leukemias (AML) was used to analyze the expression of the macrophage colony stimulating factor (M-CSF) and its corresponding receptor (c-fms). Increased methylation of the c-fms protooncogene in acute myelomonocytic leukemias. | Human | CREBBP | 1387 | CREB binding protein | The CBP gene was recently identified as a partner gene in the t(8;16) that occurs in acute myelomonocytic leukemia (AML-M4) de novo and rarely in treatment-related acute myeloid leukemia. | Human | CD53 | 963 | CD53 molecule | [Monoclonal antibodies BCA-09 against blast cell surface antigen in acute myelomonoblastic leukemia] | Human | CD33 | 945 | CD33 molecule | The study of myeloid antigens detected by CD13, CD33, and CD14 is also informative and complementary, both in diagnosing and subdividing the AML and AMML/AMoL groups. | Human | CD14 | 929 | CD14 molecule | CD14 was insensitive for confirming MCs; other characteristic markers of MCs were absent or partially lost in AMML and AMoL. The study of myeloid antigens detected by CD13, CD33, and CD14 is also informative and complementary, both in diagnosing and subdividing the AML and AMML/AMoL groups. | Human | CBFB | 865 | core-binding factor, beta subunit | Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16. We present here a case of acute myeloid leukemia M4 with eosinophilia (AML-M4Eo) positive for the CBFb/MYH11 rearrangement and carrying a t(1;12)(q25;p13) that involves the ETV6 gene at 12p13. |
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