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Details
Link-It Detail - Disease - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Debug Stats
  • ### Total Build Time: 451 ms 63.613 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 394 bytes
  • CONCEPT_SOLR_HIT_STATS gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 572 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=9 ms Completed: 9 ms rowSize= 999 bytes
  • CONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 1.421 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.791 KB
  • CONCEPT_RELATIONSHIPS gt=304 ms Completed: 304 ms rowSize= 17.430 KB
  • CONCEPT_GENES gt=115 ms Completed: 115 ms rowSize= 38.661 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.182 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive C0023473
Definition (1)
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Myeloproliferative Disorders C0027022
img Leukemia, Myeloid C0023470
Children (3)
img Blast Crisis C0005699
img Leukemia, Myeloid, Chronic-Phase C0023474
img Leukemia, Myeloid, Accelerated Phase C0023472
Ancestral Roots
RootRoot Plus OneDepthParent
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Myeloproliferative Disorders C0027022
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Leukemia, Myeloid C0023470
Relationships (242)

Relation Types:
diso_​to_​anat : 30
diso_​to_​chem : 88
diso_​to_​diso : 81
diso_​to_​gene : 20
diso_​to_​phen : 2
diso_​to_​phys : 21


Relationships:
none : 129
associated_​with : 2
classifies : 1
clinically_​similar : 2
gene_​associated_​with_​disease : 17
gene_​product_​malfunction_​associated_​with_​disease : 5
inheritance_​type_​of : 1
is_​abnormal_​cell_​of_​disease : 5
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​finding_​of_​disease : 2
is_​not_​molecular_​abnormality_​of_​disease : 3
is_​not_​normal_​cell_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 16
manifestation_​of : 6
mapped_​to : 3
may_​treat : 35
related_​to : 4
use : 1
Page Size
Current 25
  Page 1 of 10
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN1120img genetic aspects C0017399
DISO_to_CHEM1098img Pyrimidines C0034289
DISO_to_CHEM908img Piperazines C0031958
DISO_to_PHEN824img genetic aspects C0017399
DISO_to_CHEM792img Pyrimidines C0034289
DISO_to_CHEM769img Antineoplastic Agents C0003392
DISO_to_CHEM764img Piperazines C0031958
DISO_to_CHEM627img Antineoplastic Agents C0003392
DISO_to_CHEM524img Protein Kinase Inhibitors C1449702
DISO_to_CHEM490img Fusion Proteins, bcr-abl C0004891
DISO_to_CHEM366img Fusion Proteins, bcr-abl C0004891
DISO_to_PHYS259img ANTINEOPL AGENT RESISTANCE C0282588
DISO_to_CHEM215img Protein Tyrosine Kinase C0033681
DISO_to_CHEM201img Thiazoles C0039859
DISO_to_DISO178img Complication Aspects C1171258
DISO_to_DISO175img Complication Aspects C1171258
DISO_to_ANAT135img In Blood C0005768
DISO_to_PHYS132img Apoptosis C0162638
DISO_to_CHEM130img Protein Tyrosine Kinase C0033681
DISO_to_DISO125img Blast Crisis C0005699
DISO_to_CHEM120img Interferon-alpha C0002199
DISO_to_DISO118img Blast Crisis C0005699
DISO_to_ANAT115img In Blood C0005768
DISO_to_ANAT111img Cell, Neoplastic Stem C1956421
DISO_to_CHEM105img Enzyme Inhibitors C0014432
Genes (322)

Species:
human : 317
mouse : 5
Page Size
Current 25
  Page 1 of 13
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseBACH260468BTB and CNC homology 1, basic leucine zipper transcription factor 2
img NCI, Score=801, Pubmed Id: 17018862, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 17018862, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 17018862, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 17018862, UMLKSK CUI: C0023473
MouseJUNB3726jun B proto-oncogene
img NCI, Score=801, Pubmed Id: 11163237, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 10714213, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 10714213, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 17189224, UMLKSK CUI: C0023473
MouseHCK3055hemopoietic cell kinase
img NCI, Score=801, Pubmed Id: 15098032, UMLKSK CUI: C0023473
MouseGRB22885growth factor receptor-bound protein 2
img NCI, Score=801, Pubmed Id: 15143164, UMLKSK CUI: C0023473
MouseALOX15246arachidonate 15-lipoxygenase
img NCI, Score=801, Pubmed Id: 17043146, UMLKSK CUI: C0023473
HumanPPBPL1728045
img NCI, Score=801, Pubmed Id: 92163, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 9639779, UMLKSK CUI: C0023473
HumanLOC644165644165
img NCI, Score=801, Pubmed Id: 15059144, UMLKSK CUI: C0023473
HumanERVK7449619
img NCI, Score=801, Pubmed Id: 7504541, UMLKSK CUI: C0023473
HumanMIR17406952microRNA 17
img GENERIF, Score=1000, Pubmed Id: 17284533, UMLKSK CUI: C0023473
HumanMIR10A406902microRNA 10a
img GENERIF, Score=1000, Pubmed Id: 19074828, UMLKSK CUI: C0023473
HumanFLJ42953400892
img NCI, Score=801, Pubmed Id: 3118359, UMLKSK CUI: C0023473
Humandr53282811
img NCI, Score=801, Pubmed Id: 7909466, UMLKSK CUI: C0023473
HumanNCR3259197natural cytotoxicity triggering receptor 3
img NCI, Score=801, Pubmed Id: 15654827, UMLKSK CUI: C0023473
HumanANO5203859anoctamin 5
img NCI, Score=801, Pubmed Id: 15067359, UMLKSK CUI: C0023473
HumanANO6196527anoctamin 6
img NCI, Score=801, Pubmed Id: 15067359, UMLKSK CUI: C0023473
HumanCLEC12A160364C-type lectin domain family 12, member A
img NCI, Score=801, Pubmed Id: 15548716, UMLKSK CUI: C0023473
HumanSIRPA140885signal-regulatory protein alpha
img NCI, Score=801, Pubmed Id: 10572074, UMLKSK CUI: C0023473
HumanPACRG135138PARK2 co-regulated
img NCI, Score=801, Pubmed Id: 16287063, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 16287063, UMLKSK CUI: C0023473
HumanGIPC3126326GIPC PDZ domain containing family, member 3
img NCI, Score=801, Pubmed Id: 11836571, UMLKSK CUI: C0023473
HumanMSI2124540musashi RNA-binding protein 2
img NCI, Score=801, Pubmed Id: 12649177, UMLKSK CUI: C0023473
HumanLHX489884LIM homeobox 4
img NCI, Score=801, Pubmed Id: 14506703, UMLKSK CUI: C0023473
HumanUBASH3B84959ubiquitin associated and SH3 domain containing B
img GENERIF, Score=717, Pubmed Id: 15388581, UMLKSK CUI: C0023473
HumanNUDCD184955NudC domain containing 1
img NCI, Score=801, Pubmed Id: 11416219, UMLKSK CUI: C0023473
img NCI, Score=801, Pubmed Id: 11416219, UMLKSK CUI: C0023473
HumanCDCA783879cell division cycle associated 7
img NCI, Score=801, Pubmed Id: 15994934, UMLKSK CUI: C0023473
HumanCOL18A180781collagen, type XVIII, alpha 1
img GENERIF, Score=1000, Pubmed Id: 17067672, UMLKSK CUI: C0023473
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023473Leukemia, Myelogenous, Chronic, BCR-ABL Positive0self