Mouse | BCL11A | 53335 | B-cell CLL/lymphoma 11A (zinc finger protein) | Evi9, a common site of retroviral integration in BXH2 murine myeloid leukemias, encodes a C2H2 zinc finger protein and is overexpressed in these leukemic cells. Evi9 is a common site of retroviral integration in BXH2 murine myeloid leukemias. |
Mouse | BATF | 10538 | basic leucine zipper transcription factor, ATF-like | Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. |
Mouse | MRVI1 | 10335 | murine retrovirus integration site 1 homolog | Taken together, these data suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. |
Mouse | SOCS3 | 9021 | suppressor of cytokine signaling 3 | Northern blotting analysis and functional studies demonstrated that SSI-2 and SSI-3 mRNA were also induced by cytokine stimulation and their forced expression in mouse myeloid leukemia cell, M1, suppressed the apoptotic effect of LIF, like SSI-1. |
Mouse | CCNA1 | 8900 | cyclin A1 | To evaluate whether cyclin A1 is directly involved with the development of myeloid leukemia, mouse cyclin A1 protein was overexpressed in the myeloid lineage of transgenic mice under the direction of the human cathepsin G (hCG) promoter. |
Mouse | SOCS2 | 8835 | suppressor of cytokine signaling 2 | Northern blotting analysis and functional studies demonstrated that SSI-2 and SSI-3 mRNA were also induced by cytokine stimulation and their forced expression in mouse myeloid leukemia cell, M1, suppressed the apoptotic effect of LIF, like SSI-1. |
Mouse | WNT5A | 7474 | wingless-type MMTV integration site family, member 5A | Wnt5a hemizygous mice develop myeloid leukemias and B cell lymphomas that are clonal in origin and display loss of Wnt5a function in tumor tissues. |
Mouse | VIS1 | 7435 | viral integration site 1 | Click here to display 3 evidence detail records. |
Mouse | VCAM1 | 7412 | vascular cell adhesion molecule 1 | In the search for agents effective against immune-mediated disorders and inflammation, we have screened Malaysian medicinal plants for the ability to inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of murine endothelial cells (F-2), and mouse myeloid leukaemia cells (M1), respectively. |
Mouse | TFRC | 7037 | transferrin receptor (p90, CD71) | Decrease of transferrin receptor during mouse myeloid leukemia (M1) cell differentiation. |
Mouse | TEC | 7006 | transient erythroblastopenia of childhood | In screening of interleukin 3 (IL-3)-dependent myeloid leukemia cells for protein tyrosine kinases, we observed that all cell lines examined expressed high levels of Tec transcripts. |
Mouse | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | M1 mouse myeloid leukemia cells arrest growth and differentiate into macrophages following treatment with interleukin 6 (IL-6) or leukemia inhibitory factor (LIF), and recent studies have shown that Stat3 plays a central role in this process. |
Mouse | SPI1 | 6688 | spleen focus forming virus (SFFV) proviral integration oncogene | PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain. |
Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Differentiation inhibitory factor (nm23 protein) inhibited the induction of differentiation of mouse myeloid leukemia M1 and WEHI-3BD+ and human erythroleukemia HEL, KU812, and K562 cells. We recently identified a differentiation inhibitory factor (I-factor) in mouse myeloid leukemia M1 cells as a murine homolog of the human nm23-H2 gene product. nm23 genes encode proteins that participate in tumor metastasis regulation and in various fundamental cellular processes, although their mechanisms of action are still unknown. |
Mouse | MPL | 4352 | myeloproliferative leukemia virus oncogene | PEG-rHuMGDF administration also resulted in prolonged survival of mice transplanted with a c-Mpl-expressing erythroleukemia, but had no effect on survival of mice transplanted with a myeloblastic leukemia that does not possess c-Mpl. To investigate the functional domains for signal transduction of human Mpl, we constructed a series of human c-mpl cDNAs with various deletions in the cytoplasmic domain, and then introduced each cDNA into murine IL-3-dependent myeloid leukemia FDC/P2 cells to establish stable transformants. |
Mouse | MLLT3 | 4300 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | Two of these partners, ENL and AF9, code for proteins that are highly similar to each other and as fusions with HRX induce myeloid leukemias in mice as demonstrated by retroviral gene transfer and knock-in experiments, respectively. |
Mouse | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Demonstration of migration inhibitory factor (MIF) in a murine system using myelomonocytic leukemia cells (WEHI-3). |
Mouse | MEIS1 | 4211 | Meis homeobox 1 | Click here to display 9 evidence detail records. |
Mouse | JUNB | 3726 | jun B proto-oncogene | Inhibition by interleukin 4 of leukemia inhibitory factor-, interleukin 6-, and dexamethasone-induced differentiation of mouse myeloid leukemia cells: role of c-myc and junB proto-oncogenes. |
Mouse | IL3 | 3562 | interleukin 3 (colony-stimulating factor, multiple) | Click here to display 4 evidence detail records. |
Mouse | HSPA8 | 3312 | heat shock 70kDa protein 8 | To determine the functional significance of endoplasmic reticulum chaperones in hematopoietic cells, we analyzed the expression and post-translational modification of BiP/GRP78 and GRP94 as well as the cytoplasmic chaperones HSP70 and HSC70 during the differentiation of a mouse myeloid leukemia cell line, M1. |
Mouse | HOXB8 | 3218 | homeobox B8 | The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neoplasia. |
Mouse | HOXA9 | 3205 | homeobox A9 | Click here to display 7 evidence detail records. |
Mouse | HOXA7 | 3204 | homeobox A7 | Click here to display 3 evidence detail records. |
Mouse | HMGB2 | 3148 | high mobility group box 2 | Conservation of chromosomal high mobility group proteins HMG1 and HMG2 during differentiation of mouse myeloid leukemia cells. The possible change in the levels of high mobility group proteins HMG1, HMG2 and histone H1 and H1(0) was investigated during mouse myeloid leukemia (M1) cell differentiation. |