Mouse | TRIB2 | 28951 | tribbles homolog 2 (Drosophila) | In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). |
Mouse | CCNA1 | 8900 | cyclin A1 | Click here to display 3 evidence detail records. |
Mouse | MLLT10 | 8028 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. We recently showed in a murine model of the CALM/AF10 fusion gene positive leukemia, that progenitors with lymphoid characteristics can be leukemic stem cell (LSC) candidates in AML. |
Mouse | TCF3 | 6929 | transcription factor 3 | Infusion of E2a/Pbx1 pro-T cells in mice caused T lymphoblastic leukemia and, unexpectedly, acute myeloid leukemia. |
Mouse | SSFA2 | 6744 | sperm specific antigen 2 | We herein describe the first permanent, factor-independent c-kit(hi+) cell line CS-1 derived from an unrelated donor stem cell transplanted patient with relapsed acute myeloid leukemia (AML)-M5a of high-risk karyotype [monosomy 7, t(2;11)(q31;p13), t(10;12)(q24;q24)]. |
Mouse | SPI1 | 6688 | spleen focus forming virus (SFFV) proviral integration oncogene | Click here to display 7 evidence detail records. |
Mouse | PLAGL2 | 5326 | pleiomorphic adenoma gene-like 2 | Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. |
Mouse | PBX1 | 5087 | pre-B-cell leukemia homeobox 1 | Infusion of E2a/Pbx1 pro-T cells in mice caused T lymphoblastic leukemia and, unexpectedly, acute myeloid leukemia. In an E2a/Pbx1 pro-T thymocyte clone that induced only pro-T acute lymphoblastic leukemia, coexpression of Bcr/Abl expanded its leukemic phenotype to include acute myeloid leukemia, suggesting that unique functions of cooperating signaling oncoproteins can influence the lymphoid versus myeloid character of E2a/Pbx1 leukemia and may cooperate with E2a/Pbx1 to dictate the pre-B-cell phenotype of human leukemia containing t(1;19). |
Mouse | NUP98 | 4928 | nucleoporin 98kDa | These experiments document cooperative effects between constitutively activated tyrosine kinases, which confer proliferative and survival properties to hematopoietic cells, with mutations that impair differentiation, such as the NUP98/HOXA9, giving rise to the acute myeloid leukemia (AML) phenotype. |
Mouse | MLLT3 | 4300 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. |
Mouse | MLF1 | 4291 | myeloid leukemia factor 1 | Mlf1 transcripts were undetectable in the lympho-hematopoietic organs of both the embryonic and adult mouse, suggesting that NPM-MLF1 contributes to the genesis of MDS/AML in part by enforcing the ectopic overexpression of MLF1 within hematopoietic tissues. cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. |
Mouse | MEIS1 | 4211 | Meis homeobox 1 | Click here to display 8 evidence detail records. |
Mouse | IL3 | 3562 | interleukin 3 (colony-stimulating factor, multiple) | In murine WEHI3B acute myeloid leukemia (AML) cells, proviral integration leads to the expression of both HoxB8 and Interleukin (IL-3). |
Mouse | HOXB8 | 3218 | homeobox B8 | In murine WEHI3B acute myeloid leukemia (AML) cells, proviral integration leads to the expression of both HoxB8 and Interleukin (IL-3). |
Mouse | HOXB4 | 3214 | homeobox B4 | Moreover, and again in contrast to HOXB4, a significant proportion of HOXA10 mice developed a transplantable acute myeloid leukemia with a latency of 19 to 50 weeks. |
Mouse | HOXA10 | 3206 | homeobox A10 | Click here to display 3 evidence detail records. |
Mouse | HOXA9 | 3205 | homeobox A9 | Click here to display 7 evidence detail records. |
Mouse | MECOM | 2122 | MDS1 and EVI1 complex locus | However, neither EVI1 nor MDS1/EVI1 was sufficient for inducing AML in mice, although EVI1 did induce some hematologic neoplasia other than AML with a low efficiency. |
Mouse | CSF1 | 1435 | colony stimulating factor 1 (macrophage) | Increased circulating colony-stimulating factor-1 (CSF-1) in SJL/J mice with radiation-induced acute myeloid leukemia (AML) is associated with autocrine regulation of AML cells by CSF-1. |
Mouse | CDX4 | 1046 | caudal type homeobox 4 | Click here to display 3 evidence detail records. |
Mouse | CD80 | 941 | CD80 molecule | In vivo experiments in the mouse DA1-3b/C3H whole-animal acute myeloid leukemia (AML) model showed that injection of Ara-C induced expression of CD80 and CD86, and decreased expression of B7-H1, indicating that chemotherapy can modify costimulatory molecule expression in vivo, in a way not necessarily observed in vitro. Ara-C also induced CD80 or CD86 expression in 14 of 21 primary cultured human AML samples. |
Human | PPBPL1 | 728045 | | INFERRED, Score=800, UMLKSK CUI: C0023467 |
Human | LOC644165 | 644165 | | Molecular data of two other Ph1 translocations, one a Ph1+bcr- acute myeloblastic leukemia in the bcr2 region, and the other an acute lymphoblastic leukemia in the bcr3 region are presented. |
Human | CCL3L3 | 414062 | chemokine (C-C motif) ligand 3-like 3 | We found that LD78 inhibits CFU-AML colony formation up to 100% for the BM in 14/16 samples studied with the average maximal inhibition of 62.7 +/- 9.1% and up to 100% for the PB in 12/13 samples studied with the average maximal inhibition of 71.4 +/- 9.9%. LD78 gene transcripts were detected in eight of eight fresh samples of cells from patients with acute nonlymphocytic leukemia (ANLL) by Northern blot analysis. |
Human | FLJ42953 | 400892 | | Molecular data of two other Ph1 translocations, one a Ph1+bcr- acute myeloblastic leukemia in the bcr2 region, and the other an acute lymphoblastic leukemia in the bcr3 region are presented. |