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Details
Link-It Detail - Disease - Leukemia, Mast-Cell
Debug Stats
  • ### Total Build Time: 96 ms 37.069 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 336 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 445 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=9 ms Completed: 9 ms rowSize= 1.394 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=14 ms Completed: 14 ms rowSize= 6.621 KB
  • CONCEPT_RELATIONSHIPS gt=51 ms Completed: 51 ms rowSize= 15.205 KB
  • CONCEPT_GENES gt=12 ms Completed: 12 ms rowSize= 11.716 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Leukemia, Mast-Cell C0023461
Definition (1)
A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.
Semantic Types (1)
Neoplastic Process (T191)
Parents (3)
img Leukemia, Myeloid, Acute C0023467
img Leukemia C0023418
img Mastocytosis, Systemic C0221013
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Leukemia, Myeloid, Acute C0023467
img Neoplasms C0027651img Neoplasms by Histologic Type C00276524img Leukemia C0023418
img Skin and Connective Tissue Diseases C0175166img Skin Diseases C00372745img Mastocytosis, Systemic C0221013
img Neoplasms C0027651img Neoplasms by Histologic Type C00276527img Mastocytosis, Systemic C0221013
img Skin and Connective Tissue Diseases C0175166img Connective Tissue Diseases C00097826img Mastocytosis, Systemic C0221013
Relationships (36)

Relation Types:
diso_​to_​anat : 15
diso_​to_​chem : 4
diso_​to_​diso : 12
diso_​to_​gene : 1
diso_​to_​phen : 4


Relationships:
none : 7
associated_​with : 1
gene_​associated_​with_​disease : 1
is_​abnormal_​cell_​of_​disease : 7
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 7
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​finding_​of_​disease : 2
may_​be_​finding_​of_​disease : 1
may_​be_​molecular_​abnormality_​of_​disease : 2
replaces : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN8img genetic aspects C0017399
DISO_to_ANAT6img Mast Cells C0024880
DISO_to_CHEM6img Proto-Oncogene Protein c-kit C0072470
DISO_to_DISO6img Mastocytosis, Systemic C0221013
DISO_to_CHEM5img Antineoplastic Agents C0003392
DISO_to_CHEM5img Proto-Oncogene Protein c-kit C0072470
DISO_to_CHEM5img Proto-Oncogene Proteins c-kit C0072470
DISO_to_ANATis_associated_anatomic_site_ofimg Bone Marrow C0005953
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow Stem Cell C1511246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Haematopoietic tissue C0229619
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Mast Cell C1708692
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Mast Cells C0024880
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Mast Cell C1514012
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Myeloid Cell C1514039
DISO_to_DISOis_finding_of_diseaseimg Aggressive Clinical Course C1332223
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg C-KIT Somatic Point Mutation C1511354
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg C-KIT Tyrosine Kinase Protein Overexpression C1511355
DISO_to_DISOis_not_finding_of_diseaseimg Ineffective Hematopoiesis C1334171
Genes (7)

Species:
human : 7
SpeciesGeneGeneIdGene NameEvidence
HumanRASGRP4115727RAS guanyl releasing protein 4
img NCI, Score=801, Pubmed Id: 11956218, UMLKSK CUI: C0023461
img GENERIF, Score=756, Pubmed Id: 11956218, UMLKSK CUI: C0023461
HumanMRAS22808muscle RAS oncogene homolog
img NCI, Score=801, Pubmed Id: 15735740, UMLKSK CUI: C0023461
HumanNTRK34916neurotrophic tyrosine kinase, receptor, type 3
img NCI, Score=801, Pubmed Id: 9292513, UMLKSK CUI: C0023461
img NCI, Score=801, Pubmed Id: 9292513, UMLKSK CUI: C0023461
HumanKIT3815v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
img NCI, Score=801, Pubmed Id: 11381374, UMLKSK CUI: C0023461
HumanITGB13688integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
img NCI, Score=801, Pubmed Id: 11381374, UMLKSK CUI: C0023461
HumanITGAV3685integrin, alpha V
img NCI, Score=801, Pubmed Id: 11381374, UMLKSK CUI: C0023461
img NCI, Score=801, Pubmed Id: 11381374, UMLKSK CUI: C0023461
HumanBTK695Bruton agammaglobulinemia tyrosine kinase
img NCI, Score=801, Pubmed Id: 8283037, UMLKSK CUI: C0023461
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023461Leukemia, Mast-Cell0self