Mouse | DLL4 | 54567 | delta-like 4 (Drosophila) | A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. The Dll4-overexpressing mice eventually developed a lethal phenotype that was characterized by the progression of a T-cell lymphoproliferative disease (restricted to BM and lymphoid tissues) to transplantable monoclonal T-cell leukemia/lymphoma scattered to multiple organs. |
Mouse | BLNK | 29760 | B-cell linker | Here we show that the differentiation regulator SLP-65 (an adaptor protein also called BLNK or BASH) inhibits pre-B-cell leukaemia in mice. Reconstitution of SLP-65 expression in a SLP-65-/- pre-B-cell line led to enhanced differentiation in vitro and prevented the development of pre-B-cell leukaemia in immune-deficient mice. |
Mouse | TCL1A | 8115 | T-cell leukemia/lymphoma 1A | Click here to display 3 evidence detail records. |
Mouse | TYK2 | 7297 | tyrosine kinase 2 | Mice deficient in TYK2 developed Abelson-induced B lymphoid leukemia/lymphoma as well as TEL-JAK2-induced T lymphoid leukemia with a higher incidence and shortened latency compared with WT controls. |
Mouse | TXN | 7295 | thioredoxin | A redox-inactive mutant thioredoxin was stably transfected into WEHI7.2 mouse lymphocytic leukemia cells and two clones were examined for growth characteristics and the induction of apoptosis by dexamethasone, etoposide, doxorubicin, and staurosporine. |
Mouse | TRIO | 7204 | trio Rho guanine nucleotide exchange factor | By screening cDNA expression libraries derived from fresh leukemic cells of adult T-cell leukemia for the potential to transform murine fibroblasts, NIH3T3, we have identified a novel transforming gene, designated Tgat. |
Mouse | TAL1 | 6886 | T-cell acute lymphocytic leukemia 1 | Click here to display 4 evidence detail records. |
Mouse | PLD2 | 5338 | phospholipase D2 | In our present study we investigated how PLD2 activity is regulated in mouse lymphocytic leukemia L1210 cells, which mainly contain PLD2, and in PLD2 -transfected COS-7 cells. |
Mouse | NOTCH3 | 4854 | notch 3 | Click here to display 3 evidence detail records. |
Mouse | NOTCH1 | 4851 | notch 1 | Click here to display 8 evidence detail records. |
Mouse | MTAP | 4507 | methylthioadenosine phosphorylase | The two lines are murine lymphocytic leukemia cells which differ in their ability to metabolize 5;-methylthioadenosine, the by-product of polyamine biosynthesis: L5178Y cells contain a specific 5;-methylthioadenosine phosphorylase; L1210 cells do not. |
Mouse | MPI | 4351 | mannose phosphate isomerase | In this paper we report a significant decrease of MPI activity in splenic lymphoid cells from AKR/J old mice with lymphocytic leukaemia in comparison to that found in splenic lymphocytes from AKR/J non-leukaemic young mice and BALB/c young and old control mice. |
Mouse | LMO1 | 4004 | LIM domain only 1 (rhombotin 1) | Transgenic mouse models of this disease demonstrate that enforced expression of Lmo1 and Lmo2 cause T cell leukaemias with long latency and that Lmo2 expression leads to an inhibition of the T cell differentiation programme, prior to overt disease. |
Mouse | IL15 | 3600 | interleukin 15 | IL-15 transgenic mice have early expansions in NK and CD8+ T lymphocytes and later develop fatal lymphocytic leukemia with a T-NK phenotype. |
Mouse | IL3 | 3562 | interleukin 3 (colony-stimulating factor, multiple) | L-8313 is a murine T-cell leukemia cell line the cells of which constitutively produce interleukin-3 (IL-3). |
Mouse | TLX1 | 3195 | T-cell leukemia homeobox 1 | We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leukemia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto-oncogene involved in human T-cell leukemia. This function for hox11 suggests that enhanced cell survival may result from the t(10;14) which activates HOX11 in T cell leukaemias, further strengthening the association between oncogene-induced cell survival and tumorigenesis. |
Mouse | ETS1 | 2113 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | A CAT construct driven by the long terminal repeat of the human T cell leukemia virus, HTLV-1 was found to be trans-activated by both Ets1 and Ets2 in NIH3T3 and HeLa cells. |
Mouse | CCR4 | 1233 | chemokine (C-C motif) receptor 4 | Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. |
Mouse | CD6 | 923 | CD6 molecule | Two hybrid clones reactive with this Tp120 antibody were established from the fusion between concanavalin A-stimulated human peripheral blood lymphocytes and hypoxanthine-guanine phosphoribosyltransferase-deficient mouse T cell leukemia, BW5147. |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | INFERRED, Score=800, UMLKSK CUI: C0023448 |
Human | CLLU1 | 574028 | chronic lymphocytic leukemia up-regulated 1 | INFERRED, Score=800, UMLKSK CUI: C0023448 |
Human | ERVK7 | 449619 | | In patients with lymphatic leukemias, a transcript of about 6 kb hybridizing with HERV-K LTR was detected that was not found in patients with myelogenous leukemias or in healthy persons. |
Human | MIR181B2 | 406956 | microRNA 181b-2 | INFERRED, Score=800, UMLKSK CUI: C0023448 |
Human | MIR181B1 | 406955 | microRNA 181b-1 | INFERRED, Score=800, UMLKSK CUI: C0023448 |
Human | MIR181A2 | 406954 | microRNA 181a-2 | INFERRED, Score=800, UMLKSK CUI: C0023448 |