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Details
Link-It Detail - Disease - Leukemia, Hairy Cell
Debug Stats
  • ### Total Build Time: 314 ms 62.398 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 387 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 474 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 991 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 4.075 KB
  • CONCEPT_RELATIONSHIPS gt=228 ms Completed: 228 ms rowSize= 16.070 KB
  • CONCEPT_GENES gt=60 ms Completed: 60 ms rowSize= 39.072 KB
  • CONCEPT_XREFS gt=10 ms Completed: 10 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=5 ms Completed: 5 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Leukemia, Hairy Cell C0023443
Hairy Cell Leukemia
Definition (1)
A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Lymphoproliferative Disorders C0024314
img Leukemia C0023418
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210704img Lymphoproliferative Disorders C0024314
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242284img Lymphoproliferative Disorders C0024314
img Neoplasms C0027651img Neoplasms by Histologic Type C00276524img Leukemia C0023418
Relationships (109)

Relation Types:
diso_​to_​anat : 23
diso_​to_​chem : 52
diso_​to_​diso : 30
diso_​to_​phen : 4


Relationships:
none : 22
associated_​with : 5
clinically_​similar : 5
is_​abnormal_​cell_​of_​disease : 8
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 5
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​finding_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 8
may_​be_​associated_​disease_​of_​disease : 2
may_​be_​molecular_​abnormality_​of_​disease : 1
may_​treat : 38
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM47img Antineoplastic Agents C0003392
DISO_to_PHEN41img genetic aspects C0017399
DISO_to_DISO40img Complication Aspects C1171258
DISO_to_CHEM37img Cladribine C0092801
DISO_to_DISO36img Complication Aspects C1171258
DISO_to_CHEM35img Antineoplastic Agents C0003392
DISO_to_CHEM32img Cladribine C0092801
DISO_to_PHEN24img genetic aspects C0017399
DISO_to_CHEM21img Antibodies, Monoclonal C0003250
DISO_to_CHEM14img Antibodies, Monoclonal C0003250
DISO_to_CHEM14img Pentostatin C0030896
DISO_to_CHEM13img B raf Kinases C0104940
DISO_to_CHEM13img Proto-Oncogene Proteins B-raf C0104940
DISO_to_DISO13img Leukemia, Lymphocytic, Chronic, B-Cell C0023434
DISO_to_ANAT10img In Blood C0005768
DISO_to_CHEM10img Pentostatin C0030896
DISO_to_ANAT9img B-Lymphocytes C0004561
DISO_to_CHEM9img ANTIBIOTICS ANTINEOPL C0003236
DISO_to_CHEM8img HEAVY CHAIN IG C0021034
DISO_to_CHEM8img Immunoglobulin Heavy Chains C0021034
DISO_to_CHEM8img Interferon-alpha C0002199
DISO_to_DISO8img Neoplasms, Second Primary C0085183
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg B lymphoblast C1516097
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B-Lymphocytes C0004561
Genes (76)

Species:
human : 76
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC100133284100133284striatin, calmodulin binding protein pseudogene
img NCI, Score=801, Pubmed Id: 11137562, UMLKSK CUI: C0023443
HumanPPBPL1728045
img NCI, Score=801, Pubmed Id: 2949773, UMLKSK CUI: C0023443
HumanMYLK391807myosin light chain kinase 3
img NCI, Score=801, Pubmed Id: 14870965, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 15308651, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 3757154, UMLKSK CUI: C0023443
HumanFCRL583416Fc receptor-like 5
img GENERIF, Score=1000, Pubmed Id: 16681430, UMLKSK CUI: C0023443
HumanTBX2130009T-box 21
img GENERIF, Score=1000, Pubmed Id: 17667540, UMLKSK CUI: C0023443
HumanTNPO230000transportin 2
img NCI, Score=801, Pubmed Id: 8409422, UMLKSK CUI: C0023443
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
img NCI, Score=801, Pubmed Id: 15163014, UMLKSK CUI: C0023443
HumanSYNJ28871synaptojanin 2
img GENERIF, Score=756, Pubmed Id: 14562116, UMLKSK CUI: C0023443
HumanIFITM18519interferon induced transmembrane protein 1
img NCI, Score=801, Pubmed Id: 2265250, UMLKSK CUI: C0023443
HumanENC18507ectodermal-neural cortex 1 (with BTB domain)
img NCI, Score=801, Pubmed Id: 15459180, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 15459180, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 15459180, UMLKSK CUI: C0023443
HumanD13S258101Disrupted in B-cell neoplasia
img NCI, Score=801, Pubmed Id: 11463458, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 11463458, UMLKSK CUI: C0023443
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 11368435, UMLKSK CUI: C0023443
HumanVCAM17412vascular cell adhesion molecule 1
img NCI, Score=801, Pubmed Id: 8916961, UMLKSK CUI: C0023443
HumanUNG7374uracil-DNA glycosylase
img NCI, Score=801, Pubmed Id: 3796034, UMLKSK CUI: C0023443
HumanTPH17166tryptophan hydroxylase 1
img NCI, Score=801, Pubmed Id: 6117601, UMLKSK CUI: C0023443
HumanTK17083thymidine kinase 1, soluble
img NCI, Score=801, Pubmed Id: 6836228, UMLKSK CUI: C0023443
HumanTGFB17040transforming growth factor, beta 1
img GENERIF, Score=1000, Pubmed Id: 14991065, UMLKSK CUI: C0023443
HumanSMO6608smoothened, frizzled family receptor
img NCI, Score=801, Pubmed Id: 6602365, UMLKSK CUI: C0023443
HumanSELL6402selectin L
img NCI, Score=801, Pubmed Id: 11172297, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 9067581, UMLKSK CUI: C0023443
HumanSDC16382syndecan 1
img NCI, Score=801, Pubmed Id: 10619261, UMLKSK CUI: C0023443
HumanRAB1A5861RAB1A, member RAS oncogene family
img NCI, Score=801, Pubmed Id: 2194392, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 3531732, UMLKSK CUI: C0023443
HumanPTGER15731prostaglandin E receptor 1 (subtype EP1), 42kDa
img NCI, Score=801, Pubmed Id: 10807413, UMLKSK CUI: C0023443
HumanTMPRSS155651transmembrane protease, serine 15
img NCI, Score=801, Pubmed Id: 454624, UMLKSK CUI: C0023443
HumanABCB45244ATP-binding cassette, sub-family B (MDR/TAP), member 4
img NCI, Score=801, Pubmed Id: 1972761, UMLKSK CUI: C0023443
img NCI, Score=801, Pubmed Id: 1827314, UMLKSK CUI: C0023443
HumanMNDA4332myeloid cell nuclear differentiation antigen
img NCI, Score=801, Pubmed Id: 10492038, UMLKSK CUI: C0023443
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023443Leukemia, Hairy Cell0self