Genes (1590)
Species: human : 1524 mouse : 66 | |
Mouse | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | This treatment combined with the administration of the mentioned inhibitors of ornithine decarboxylase and polyamine oxidase completely prevents Lewis lung carcinoma from growing, and prolongs considerably the average life span of L1210 leukemia mice. We have recently established that combination therapy with N,N;-bis[3-(ethylamino)propyl]-1,7-heptanediamine (BEPH), a synthetic polyamine analogue, and N,N;-bis-2,3-butadieneyl-putrescine, a polyamine oxidase inhibitor, eradicated L1210 leukemia in mice and induced resistance to a subsequent L1210 challenge. | Mouse | CLNK | 116449 | cytokine-dependent hematopoietic cell linker | Stimulatory effects of Clnk on immunoreceptor signaling were also reported to occur in transfected B-cell and basophil leukemia cell lines. | Mouse | PRDM16 | 63976 | PR domain containing 16 | Integrations are located in intron 1 or 2, where they promote expression of truncated proteins lacking the PRDI-BF1-RIZ1 homologous (PR) domain, similar to what is observed in human leukemias with EVI1 or PRDM16 mutations. | Mouse | GAS5 | 60674 | growth arrest-specific 5 (non-protein coding) | In Friend leukemia and NIH 3T3 cells, the levels of gas5 gene mRNA were high in saturation density-arrested cells and almost undetectable in actively growing cells. | Mouse | SMOX | 54498 | spermine oxidase | We have recently established that combination therapy with N,N;-bis[3-(ethylamino)propyl]-1,7-heptanediamine (BEPH), a synthetic polyamine analogue, and N,N;-bis-2,3-butadieneyl-putrescine, a polyamine oxidase inhibitor, eradicated L1210 leukemia in mice and induced resistance to a subsequent L1210 challenge. This treatment combined with the administration of the mentioned inhibitors of ornithine decarboxylase and polyamine oxidase completely prevents Lewis lung carcinoma from growing, and prolongs considerably the average life span of L1210 leukemia mice. | Mouse | GPR132 | 29933 | G protein-coupled receptor 132 | The target cell type and anatomical locations of leukemia development are indistinguishable in animals transplanted with G2A+/+ or G2A-/- cells. | Mouse | BLNK | 29760 | B-cell linker | Here, we show that, similarly to SLP-65, the adaptor protein LAT (linker for activation of T cells) limits pre-B cell proliferation and reduces the potential of a tumorgenic pre-B cell line to develop leukemia in immune-deficient mice. | Mouse | AFF4 | 27125 | AF4/FMR2 family, member 4 | Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia. | Mouse | LAT | 27040 | linker for activation of T cells | Here, we show that, similarly to SLP-65, the adaptor protein LAT (linker for activation of T cells) limits pre-B cell proliferation and reduces the potential of a tumorgenic pre-B cell line to develop leukemia in immune-deficient mice. | Mouse | KLF1 | 10661 | Kruppel-like factor 1 (erythroid) | Furthermore, recruitment of EKLF to 5;HS3 only occurred in beta-globin-expressing murine erythroid leukemia cells, whereas recruitment of EKLF to 5;HS2 occurred in both gamma-globin-expressing K562 cells and murine erythroid leukemia cells. | Mouse | MRVI1 | 10335 | murine retrovirus integration site 1 homolog | Ecotropic virus did not disrupt Mrvi1 in 205 ecotropic virus-positive leukemias, suggesting that Mrvi1 is specifically targeted by MRV. One new site, Mrvi1 was identified that was disrupted by MRV in two of the leukemias. | Mouse | SOCS3 | 9021 | suppressor of cytokine signaling 3 | In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF). | Mouse | CCNA1 | 8900 | cyclin A1 | Finally, cyclin A1 might be a therapeutic target since its silencing inhibited leukemia cell growth.Oncogene (2005) 24, 2739-2744. Overexpression of cyclin A1 was found in acute myeloid leukemia and cyclin A1 induced leukemia in a transgenic mouse model. | Mouse | TCL1A | 8115 | T-cell leukemia/lymphoma 1A | The TCL1 oncogene is activated in these leukemias by juxtaposition to the alpha or beta locus of the T cell receptor, caused by chromosomal translocations t(14:14)(q11:q32), t(7:14)(q35:q32), or by inversions inv(14)(q11:q32). Younger mice presented preleukemic T cell expansions expressing TCL1, and leukemias developed only at an older age. | Mouse | MLLT10 | 8028 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | We recently showed in a murine model of the CALM/AF10 fusion gene positive leukemia, that progenitors with lymphoid characteristics can be leukemic stem cell (LSC) candidates in AML. Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. | Mouse | TYK2 | 7297 | tyrosine kinase 2 | RAG2/TYK2 double-knockout mice succumbed to A-MuLV-induced leukemia/lymphoma faster than RAG2(-/-)TYK2(+/-) mice. | Mouse | TEC | 7006 | transient erythroblastopenia of childhood | To examine its oncogenicity in vivo and to create an animal model for BCR/ABL-positive leukemias, we generated transgenic mice expressing p210bcr/abl driven by the promoter of the mouse tec gene, a cytoplasmic tyrosine kinase preferentially expressed in early hematopoietic progenitors. | Mouse | TCF12 | 6938 | transcription factor 12 | Click here to display 3 evidence detail records. | Mouse | TAL1 | 6886 | T-cell acute lymphocytic leukemia 1 | Thus, despite SCL being strongly implicated in the development of human leukemia, its enforced expression in mice using a retrovirus and bone marrow reconstitution was insufficient to generate leukemia. | Mouse | STAT5B | 6777 | signal transducer and activator of transcription 5B | Click here to display 4 evidence detail records. | Mouse | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | M1 mouse myeloid leukemia cells arrest growth and differentiate into macrophages following treatment with interleukin 6 (IL-6) or leukemia inhibitory factor (LIF), and recent studies have shown that Stat3 plays a central role in this process. | Mouse | ST14 | 6768 | suppression of tumorigenicity 14 (colon carcinoma) | This gene, Prss14 (protease, serine, 14), was mapped to mouse chromosome 9 and is closely linked to the Fli1 (Friend leukemia integration 1) gene. | Mouse | SRM | 6723 | spermidine synthase | Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine synthase against P388 leukemia. The antitumor effect of dicyclohexylammonium sulfate (DCHA), a potent inhibitor of spermidine synthase, was tested on BDF1 mice inoculated i.p. with P388 leukemia (1 X 10(6) cells/mouse). | Mouse | SPI1 | 6688 | spleen focus forming virus (SFFV) proviral integration oncogene | Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RAR{alpha}. The rates of rearrangement of the Spi-1 (PU.1 ) oncogene by provirus integration and alteration of the p53 tumor-suppressor gene were the same in leukemia cell lines derived from folate-deficient mice as they were in cell lines from control mice. | Mouse | PTPN11 | 5781 | protein tyrosine phosphatase, non-receptor type 11 | Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. We found that Shp2 mutants associated with sporadic leukemias transform murine bone marrow cells, whereas NS mutants are less potent in this assay. |
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