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Genes (22)
Species: human : 22 | |
Human | LOC100507436 | 100507436 | | The MICA*5A5.1 allele, associated with leprosy susceptibility, encodes a protein lacking a cytoplasmic tail providing a possible mechanism for defective immune surveillance against mycobacteria | Human | PACRG | 135138 | PARK2 co-regulated | Title:|Association:Not Found|Conclusion:Not Found Title:Susceptibility to leprosy is associated with PARK2 and PACRG.|Association:Y|Conclusion:Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy | Human | BTNL2 | 56244 | butyrophilin-like 2 (MHC class II associated) | a major effect of the BTNL2 rs2076530 (G --> A) SNP in Crohn's disease and tuberculosis was excluded; there was an association with susceptibility to leprosy (P=0.04), however, this is most likely due to linkage disequilibrium with HLA-DR | Human | CD209 | 30835 | CD209 molecule | Expression of DC-SIGN and CD1b in human leprosy | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Title:|Association:Y|Conclusion:Not Found | Human | TNF | 7124 | tumor necrosis factor | Title:Genetics of susceptibility to leprosy.|Association:Not Found|Conclusion:Review article | Human | TLR2 | 7097 | toll-like receptor 2 | Title:TLR2 Arg677Trp polymorphism in leprosy: revisited.|Association:Not Found|Conclusion:Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream. Expression of the Arg677Trp variant of human TLR2, which was identified in Korean patients with lepromous leprosy, was not able to mediate a response to either M. leprae or M. tuberculosis Susceptibility to infection by Mycobacterium leprae causing leprosy | Human | TLR1 | 7096 | toll-like receptor 1 | Susceptibility to infection by Mycobacterium leprae causing leprosy | Human | SLC11A1 | 6556 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | Title:Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.|Association:Not Found|Conclusion:Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type. Title:Genetics of susceptibility to leprosy.|Association:Not Found|Conclusion:Review article promoter polymorphism exhibited an interaction with the lepromin response, suggesting a susceptibility to leprosy Suggestive linkage was found at the SLC11A1 locus for the quantitative Mitsuda reaction in 19 Vietnamese families with leprosy Title:Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans.|Association:Not Found|Conclusion:Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type. | Human | SLAMF1 | 6504 | signaling lymphocytic activation molecule family member 1 | During ligation of SLAM in leprosy, signaling molecules and transcription factors participate in the induction or reinforcement of interferon-gamma production, promoting cell-mediated immune responses to mycobacterial infection | Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | There were significantly greater concentrations of the chemokines CCL3 and CCL11 in plasma of leprosy patients than in non-infected individuals | Human | PARK2 | 5071 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | Title:Susceptibility to leprosy is associated with PARK2 and PACRG.|Association:Y|Conclusion:Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy. Title:|Association:Not Found|Conclusion:Not Found Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy | Human | NINJ1 | 4814 | ninjurin 1 | Our data suggests that Ninjurin 1 asp110ala SNP could be a valuable genetic marker of nerve damage in leprosy | Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | MBL2-gene polymorphisms play a role in susceptibility to leprosy per se and in the clinical progression of the disease | Human | LTA | 4049 | lymphotoxin alpha | LTA is a major gene associated with early-onset leprosy Title:Genetics of susceptibility to leprosy.|Association:Not Found|Conclusion:Review article | Human | LAMA2 | 3908 | laminin, alpha 2 | Title:Association of a missense mutation of the laminin alpha2 gene with tuberculoid type of leprosy in Indonesian patients.|Association:Y|Conclusion:There was no significant difference in the incidence of the polymorphisms between patients and non-patients. Remarkably, it was found that a missense mutation (T7809C) substituting valine with alanine (V2587A) was found to be more frequent in the tuberculoid type than in the lepromatous type leprosy. It is supposed that this missense mutation is one of the determinant factors in the early onset of peripheral nerve damage in Indonesian tuberculoid leprosy patients. | Human | IL12RB2 | 3595 | interleukin 12 receptor, beta 2 | Title:Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity.|Association:Not Found|Conclusion:SNPs within the 5' flanking region of IL12RB2 affect the degree of expression of this gene and may be implicated in individual differences in CMI responsiveness to mycobacterial antigens, leading to lepromatous or tuberculoid leprosy. | Human | IL12RB1 | 3594 | interleukin 12 receptor, beta 1 | Title:Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea.|Association:Not Found|Conclusion:In conclusion, missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14 M), and 1443 T/C (L467P) of the IFNGR1 encoding genes have no association with the susceptibility to lepromatous leprosy in the Korean population. | Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | Polymorphic variants in the IL12B gene is associated with leprosy and tuberculosis | Human | IL10 | 3586 | interleukin 10 | Haplotypes for IL-10 defined by three SNP positions (-3575, -2849 and -2763) captured significant differences between controls and leprosy patients (P=0.04) | Human | HLA-DRB1 | 3123 | | HLA-DRB1*10 is associated with susceptibility to leprosy and HLA-DRB1*04 is associated with resistance, both in the Brazilian and Vietnamese populations; these alleles play a role in activation of cellular immune responses against M. leprae | Human | HLA-A | 3105 | | Significant increase in frequency of HLA-A were observed in leprosy patients when compared with controls |
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