Genes (92)
Species: human : 92 | |
Human | MIRLET7A1 | 406881 | microRNA let-7a-1 | Let-7-mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth | Human | GNRHR2 | 114814 | gonadotropin-releasing hormone (type 2) receptor 2 | Expression of GnRH2 protein and receptor (GnRHR2) is confirmed in both leiomyoma and patient-matched myometrium | Human | WNT5B | 81029 | wingless-type MMTV integration site family, member 5B | Treatment with 9-cis retinoic acid significantly inhibited Wnt5b expression in myometrial SMC but not in their leiomyoma counterparts. Main Outcome Measures: The expression patterns of two members of the Wnt pathway, Wnt5b and secreted frizzled related protein (sFRP)1, were evaluated in myometrial SMC (n = 22) and in leiomyoma cells (n = 27) by real-time quantitative PCR. Overexpression of the wnt5b gene in leiomyoma cells: implications for a role of the wnt signaling pathway in the uterine benign tumor. In leiomyoma cells, the regulation of Wnt5b expression by retinoids appears to be attenuated | Human | PDGFC | 56034 | platelet derived growth factor C | Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium | Human | ANGPT4 | 51378 | angiopoietin 4 | Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas | Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Increased expression of the genes for pregnancy-associated plasma protein A (PAPPA), tomoregulin, cellular retinoid acid binding protein 1 (CRABP1), zinc finger protein 185 (ZFP 185) and latent transforming growth factor beta binding protein 2 (LTBP2) was demonstrated in individual leiomyoma samples compared with corresponding myometrium. | Human | OPN3 | 23596 | opsin 3 | INFERRED, Score=800, UMLKSK CUI: C0023267 | Human | FERMT2 | 10979 | fermitin family member 2 | Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus | Human | ABI2 | 10152 | abl-interactor 2 | The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta. The objective of this study was to evaluate the expression of Abi-2 in leiomyoma/myometrium during the menstrual cycle and following GnRH analogue (GnRHa) therapy, as well as regulation by transforming growth factor (TGF)-beta1 in leiomyoma and myometrial smooth muscle cells (LSMC and MSMC). Western blotting showed a similar trend in Abi-2 protein expression in leiomyoma/myometrial tissue extracts, which was immunolocalized in LSMC and MSMC, connective tissue fibroblasts and arterial walls. METHODS: We used real-time PCR, Western blotting and immunohistochemistry to determine the expression of Abi-2 in paired leiomyoma and myometrium (n = 27) from proliferative (n = 8) and secretory (n = 12) phases of the menstrual cycle and from patients who received GnRHa therapy (n = 7). | Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | In summary, we have shown for the first time that PTTG-1 is up-regulated in human uterine leiomyomas and that the positive feedback loop between PTTG-1 and bFGF may be pivotal in the growth of leiomyoma cells. By comparing 23 pairs of leiomyomas and matched pairs of myometria, we found that the expression of PTTG-1 is significantly elevated in leiomyoma. Western blotting analysis demonstrates that the expressions of PTTG-1, bFGF, and the cell proliferation marker, proliferating cell nuclear antigen, are positively correlated with each other, which supports the hypothesis that the positive feedback loop between PTTG-1 and bFGF increases leiomyoma cell proliferation. PTTG-1 is up-regulated in human uterine leiomyomas and that the positive feedback loop between PTTG-1 and basic fibroblast growth factor may be pivotal in the growth of leiomyoma cells | Human | EXO1 | 9156 | exonuclease 1 | INFERRED, Score=800, UMLKSK CUI: C0023267 | Human | WISP2 | 8839 | WNT1 inducible signaling pathway protein 2 | Furthermore, we examine CCN5 mRNA expression in 10 autologous pairs of human myometrial and leiomyoma tissues and determine that CCN5 is down-regulated in 100% of the leiomyoma tissues analysed when compared to their normal myometrial counterparts. Using autologous human myometrial and leiomyoma smooth muscle cells, we demonstrate that the proliferation and motility of both cell types are inhibited by the overexpression of CCN5. | Human | AOC3 | 8639 | amine oxidase, copper containing 3 | In tumors, VAP-1 is retained on all leiomyoma cells, whereas it is lost in half of leiomyosarcoma samples. | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | Click here to display 9 evidence detail records. | Human | MAP3K12 | 7786 | mitogen-activated protein kinase kinase kinase 12 | MAIN OUTCOME MEASURE(S): Expression of mRNA transcripts and protein in fibroid compared with myometrium.A more extensive microarray confirmed differential expression of Frizzled-2 and CD-24 but did not confirm Dlk overexpression. RT-PCR and real-time PCR demonstrated equivalent Dlk mRNA expression between fibroid and myometrium (ratio, 1.02), a slight Frizzled-2 overexpression (ratio, 2.09), and robust CD-24 overexpression in fibroids (ratio, 12.35). | Human | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | Polymorphisms of XRCC4 promoter are associated with higher susceptibility of leiomyoma, and XPD promoter polymorphisms are not | Human | WNT7A | 7476 | wingless-type MMTV integration site family, member 7A | Referring to their results, we have postulated that hypersensitivity of leiomyoma cells to estrogen may deregulate the Wnt7a expression. Decreased expression of Wnt7a may lead to loss of control in patterning of the myometrium and result in development of leiomyoma To explore the molecular mechanisms underlying the pathogenesis of uterine leiomyoma, the expression of Wnt7a mRNA in the leiomyoma has been assessed. | Human | VEGFA | 7422 | vascular endothelial growth factor A | We concluded that T homozygotes and T allele of VEGF gene -460 polymorphism are associated with higher risk of leiomyoma development | Human | TXN | 7295 | thioredoxin | Thioredoxin mRNA concentrations were determined in myometrial and fibroid tissues obtained from women during the menstrual cycle, during treatment with an analogue of gonadotrophin releasing hormone (GnRH agonist), in the postmenopausal period (PMP) and during pregnancy. | Human | TP53 | 7157 | tumor protein p53 | No somatic mutations were identified in either TP53 or KRAS, indicating that disregulation of these genes is not required for leiomyomas development The p53 codon 72 gene polymorphism is not associated with the susceptibility of leiomyomas p53 polymorphism at codon 72 predicts the susceptibility to leiomyoma in a Caucasian population and may contribute to the pathogenesis of uterine leiomyoma | Human | TNF | 7124 | tumor necrosis factor | G homozygote and G allele for TNF-alpha promoter are related to a higher risk of leiomyomas | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | We therefore examined the expression of mRNA and protein for MMPs (interstitial collagenase, MMP-1; gelatinases, MMP-2 and MMP-9; and stromelysin, MMP-3) and TIMPs (TIMP-1 and TIMP-2) in leiomyoma and matched unaffected myometrium from GnRHa (lupron)-treated and untreated patients. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | We therefore examined the expression of mRNA and protein for MMPs (interstitial collagenase, MMP-1; gelatinases, MMP-2 and MMP-9; and stromelysin, MMP-3) and TIMPs (TIMP-1 and TIMP-2) in leiomyoma and matched unaffected myometrium from GnRHa (lupron)-treated and untreated patients. The results suggest that MMP and TIMP expression in leiomyoma and myometrium are hormonally regulated, and that GnRHa-induced tumour regression is accompanied by an increase in MMP expression with a concomitant decrease in TIMP-1 expression, which may potentially provide an environment favouring ECM degradation. | Human | TGFB3 | 7043 | transforming growth factor, beta 3 | OBJECTIVE: To investigate the expression of TGF-beta3 in leiomyoma and myometrium as well as the effect of TGF-beta3 on the expression of fibronectin and on the proliferation of leiomyoma and myometrial cells. RESULT(s): The TGF-beta3 mRNA level in the leiomyoma samples was 3.5-fold higher than in the myometrial samples. The highest TGF-beta3 mRNA level was observed in leiomyoma samples from midsecretory phase and was 5-fold higher than in proliferative phase samples. INTERVENTION(s): First TGF-beta3 mRNA and protein levels in myometrium and leiomyoma were measured, and then myometrial and leiomyoma cells in culture were treated with TGF-beta3. TGF-beta3 induced fibronectin expression in leiomyoma cells and directly stimulated myometrial and leiomyoma cell proliferation in cultures. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | transforming growth factor-beta1 was produced in follicular and luteal phases and stimulated cell proliferation mainly in leiomyoma cells TGF-beta1 expression in leiomyomas and myometrium is inversely correlating with relative expression levels of CCN2, fibulin-1C and S100A4 the leiomyoma and myometrial smooth muscle cells molecular environment is targeted by the autocrine/paracrine action of TGF-beta |
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