Human | SFTPA1 | 653509 | surfactant protein A1 | The tumor of the larynx was a papillary adenocarcinoma resembling the lung tumor, both demonstrating positive immunohistochemical staining for pulmonary surfactant apoprotein. |
Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | MAGE-2 is expressed in many tumors, including melanoma, laryngeal tumors, lung tumors and sarcomas, but not in healthy tissue, with the exception of testis. |
Human | ARL11 | 115761 | ADP-ribosylation factor-like 11 | the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer |
Human | ING3 | 54556 | inhibitor of growth family, member 3 | Especially, about 63% of tongue and larynx tumors showed the decrease and a tendency of higher mortality was observed in cases with decreased ING3 expression. |
Human | CAPN10 | 11132 | calpain 10 | These results indicate that some CAPN10 alleles may be exerting a protective effect on laryngeal cancer risk in the Spanish population |
Human | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Both cell adhesion molecules, E48 and Ep-CAM, are involved in the invasion process of larynx tumor. Both cell adhesion molecules, E48 and Ep-CAM, are involved in the invasion process of larynx tumor. |
Human | D13S25 | 8101 | Disrupted in B-cell neoplasia | In the present study, 20 pairs of primary larynx tumors and their metastases were analyzed by interphase fluorescence in situ hybridization (FISH) with three different 13q-specific probes (RB1, D13S25, and 13qtel). |
Human | ZAP70 | 7535 | zeta-chain (TCR) associated protein kinase 70kDa | Both the zeta chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 gene DNA repair capacity found reduced in patients with laryngeal neoplasms |
Human | TP53 | 7157 | tumor protein p53 | P72R polymorphism in human papillomavirus associated premalignant laryngeal neoplasm The p53 level was higher than in normal larynxes, whereas laryngeal cancer presented the lowest levels |
Human | TERT | 7015 | telomerase reverse transcriptase | shRNA directed against hTERT inhibits telomerase activity through suppression of the hTERT expression in laryngeal cancer cells and that RNA interfering technology may be a promising strategy for the treatment of laryngeal cancers |
Human | STK11 | 6794 | serine/threonine kinase 11 | PTEN and LKB1 genes in laryngeal tumours. |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | Finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia |
Human | RB1 | 5925 | retinoblastoma 1 | Immunohistochemical analysis of Rb protein expression in neoplastic cells made it easier to evaluate the mechanisms of cancerogenesis in laryngeal cancer and is closely related to genetic alteration in Rb locus The pRb level was higher than in normal larynxes, whereas laryngeal cancer presented the lowest levels |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cox-2 gene expression is manifest in laryngeal cancer |
Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Comparison of the phenotype of laryngeal and hypopharyngeal tumors, irrespective of the TNM stages, revealed characteristic differences: T2 stage laryngeal tumors showed decreased CD44v3 and occasional NM23 and MMP2 positivity, while in T3 stage these tumors were characterised by increased frequency of NM23 positivity. |
Human | MGST1 | 4257 | microsomal glutathione S-transferase 1 | Polymorphisms in microsomal glutathione s transferase is associated with laryngeal cancer |
Human | MAGEA2 | 4101 | melanoma antigen family A, 2 | MAGE-2 is expressed in many tumors, including melanoma, laryngeal tumors, lung tumors and sarcomas, but not in healthy tissue, with the exception of testis. |
Human | IL8 | 3576 | interleukin 8 | The researchers found a decreased risk of laryngeal cancer when a polymorphism occurs in the minor allele A promoter |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. Polymorphism is not associated with laryngeal cancer risk in Caucasians |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. |
Human | GSTM3 | 2947 | glutathione S-transferase mu 3 (brain) | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | GSTM1 expression is visualized in laryngeal tumor tissues in smokers Results suggest that GSTM1-deleted genotype may be a genetic susceptibility marker for laryngeal cancer, and that the absence of this enzyme may have a role in the development of laryngeal cancer |
Human | EPHX1 | 2052 | epoxide hydrolase 1, microsomal (xenobiotic) | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. Polymorphisms in microsomal epoxide hydrolase is associated with laryngeal cancer |
Human | CENPB | 1059 | centromere protein B, 80kDa | The purpose of the present study is to evaluate the centromeric pattern on human laryngeal tumour (HEp-2) cells by indirect immunofluorescent (IIF) test and to compare their reactivities with a newly developed recombinant centromere protein B enzyme linked immunosorbent assay (CENP-B ELISA) test using sera of antinuclear antibody (ANA)-reactive primary biliary cirrhosis (PBC) patients. The purpose of the present study is to evaluate the centromeric pattern on human laryngeal tumour (HEp-2) cells by indirect immunofluorescent (IIF) test and to compare their reactivities with a newly developed recombinant centromere protein B enzyme linked immunosorbent assay (CENP-B ELISA) test using sera of antinuclear antibody (ANA)-reactive primary biliary cirrhosis (PBC) patients. |