Human | C1QTNF1 | 114897 | C1q and tumor necrosis factor related protein 1 | These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | We found different effects of NOD2/CARD15 haplotypes on disorders, like cardiovascular and all-cause mortality,which may be considered at least in part as chronic inflammation-driven |
Human | FOXP3 | 50943 | forkhead box P3 | |
Human | PADI1 | 29943 | peptidyl arginine deiminase, type I | peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation |
Human | KLF2 | 10365 | Kruppel-like factor 2 (lung) | KLF2 expression in circulating monocytes is reduced in patients with chronic inflammatory conditions such as coronary artery disease |
Human | CYP7B1 | 9420 | cytochrome P450, family 7, subfamily B, polypeptide 1 | Increased CYP7B activity leads to higher levels of 7alpha-OH-DHEA in synovial fluid which may contribute to the maintenance of chronic inflammation observed in rheumatoid arthritis patients |
Human | TFPI2 | 7980 | tissue factor pathway inhibitor 2 | Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes |
Human | VEGFC | 7424 | vascular endothelial growth factor C | VEGF family proteins regulate wound healing, chronic inflammation and tumour angiogenesis and lymphangiogenesis in fibroblasts |
Human | TP53 | 7157 | tumor protein p53 | p53 mutations at CpG dinucleotides provide further evidence for a molecular link between chronic inflammation and esophageal malignancy These results indicate that mutations and consequent dysfunction of P53 gene may result in chronic inflammation and hyperplasia in RA (Rheumatoid Arthritis) patients pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation |
Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | In patients with heart failure, increased sTNFR-1 as an expression of chronic inflammation is correlated with both anemia and low serum lipid fractions |
Human | TNF | 7124 | tumor necrosis factor | synthesis of adipose tissue tumor necrosis factor alpha and leptin could induce the production acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation TNF alpha triggers different effector mechanisms to directly inhibit Leydig cell StAR expression and steroidogenesis, which ultimately contribute to the global reproductive failure associated with chronic inflammation and sepsis |
Human | TLR4 | 7099 | toll-like receptor 4 | In human intrahepatic biliary epithelial cells, at least TLR2 and 4 are capable of mediating innate immune system function in vitro, suggesting the involvement of TLRs in the development of chronic inflammatory cholangiopathies |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta 1 significantly downregulated CFTR mRNA and cAMP-dependent current in nasal polyp cultures; data suggests that chronic inflammation in nasal polyposis downregulates CFTR gene and protein expression TGF-beta1 mediates a physiologically relevant regulatory mechanism, selective for memory T cells present in the tumor microenvironment and nonmalignant chronic inflammatory tissues Chronic inflammation associated with hepatitis C virus infection shifts hepatocytic TGF-beta signaling from tumor-suppression to fibrogenesis, accelerating liver fibrosis and increasing risk for hepatocarcinoma |
Human | TACR1 | 6869 | tachykinin receptor 1 | Changes in SP receptor expression during chronic inflammation suggest that SP receptors are potential targets for therapeutic regulation of the inflammatory bowel disease |
Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | The finding of increased levels of fractalkine in the blood during subacute and chronic CNS inflammation suggests that it may be an interesting regulator of leukocyte extravasation into the inflamed brain |
Human | CCL13 | 6357 | chemokine (C-C motif) ligand 13 | MCP-4 may be a critical molecule that links obesity and chronic inflammation |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | data demonstrated that chronic inflammation appeared to play roles in induction of CCAAT/enhancer-binding protein beta expression in prostate epithelium which was associated with increased Cyclooxygenase-2 expression and androgen receptor downregulation |
Human | PRKAA1 | 5562 | protein kinase, AMP-activated, alpha 1 catalytic subunit | AMPK activation is linked with reductions in cAMP-mediated epithelial chloride flux and may be a contributing factor to the hyporesponsiveness seen under conditions of chronic inflammation |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Endogenous p53 mutations at CpG dinucleotides provide further evidence for a molecular link between chronic inflammation and esophageal malignancy |
Human | NCAM1 | 4684 | neural cell adhesion molecule 1 | may explain the preferential accumulation of CD56(bright) NK cells often seen in environments rich in reactive oxygen species, such as at sites of chronic inflammation and in tumors |
Human | MAZ | 4150 | MYC-associated zinc finger protein (purine-binding transcription factor) | In transgenic mice SAF-1 plays a key role in the development of reactive amyloid A amyloidosis, a consequence of chronic inflammation |
Human | LIF | 3976 | leukemia inhibitory factor | Constitutive expression of cytokines in brain induces changes in gene expression characteristic of chronic inflammation leading to either temporal weight reduction (CNTF) or severe cachexia (leukemia inhibitory factor) |
Human | LEP | 3952 | leptin | synthesis of adipose tissue tumor necrosis factor alpha and leptin could induce the production acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation |
Human | CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | The existence of CXCL10 and CXCR3 with other CXC/CC chemokine signature in chronic pancreatitis is suggestive of their vital role in the progression of chronic inflammation |
Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | A heightened, perhaps persistent, activational state of IL-12(p40)/Stat4 signaling may be present in active Chinese ulcerative colitis (UC) patients, and possibly involved in chronic inflammation in UC |