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Details
Link-It Detail - Disease - Hypothyroidism
Debug Stats
  • ### Total Build Time: 552 ms 49.413 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 326 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 410 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=2 ms Completed: 2 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 552 bytes
  • CONCEPT_CHILDREN gt=5 ms Completed: 5 ms rowSize= 989 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.505 KB
  • CONCEPT_RELATIONSHIPS gt=482 ms Completed: 482 ms rowSize= 15.665 KB
  • CONCEPT_GENES gt=37 ms Completed: 37 ms rowSize= 28.660 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.148 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Hypothyroidism C0020676
Definition (1)
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Thyroid Diseases C0040128
Children (2)
img Congenital Hypothyroidism C0010308
img Myxedema C0027145
Ancestral Roots
RootRoot Plus OneDepthParent
img Endocrine System Diseases C0014130img Thyroid Diseases C00401283img Thyroid Diseases C0040128
Relationships (281)

Relation Types:
diso_​to_​anat : 26
diso_​to_​chem : 124
diso_​to_​diso : 121
diso_​to_​gene : 2
diso_​to_​phen : 2
diso_​to_​phys : 6


Relationships:
none : 146
classifies : 2
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​associated_​anatomic_​site_​of : 3
is_​normal_​tissue_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 19
mapped_​to : 28
may_​prevent : 74
may_​treat : 3
permuted_​term_​of : 1
Page Size
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  Page 1 of 12
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO580img Complication Aspects C1171258
DISO_to_DISO485img Complication Aspects C1171258
DISO_to_ANAT444img In Blood C0005768
DISO_to_ANAT342img In Blood C0005768
DISO_to_CHEM312img Thyroxine C0040165
DISO_to_CHEM310img Thyroxine C0040165
DISO_to_DISO243img chemically induced C0007994
DISO_to_DISO189img chemically induced C0007994
DISO_to_DISO181img HYPERTHYROIDISM C0020550
DISO_to_DISO175img HYPERTHYROIDISM C0020550
DISO_to_CHEM150img Thyrotropin C0040160
DISO_to_ANAT118img Thyroid Gland C0040132
DISO_to_PHEN108img genetic aspects C0017399
DISO_to_ANAT107img Thyroid Gland C0040132
DISO_to_CHEM107img Thyrotropin C0040160
DISO_to_DISO107img Pregnancy Complications C0032962
DISO_to_PHEN107img genetic aspects C0017399
DISO_to_CHEM99img B30-B31 THYROID HORMONES C0040135
DISO_to_CHEM99img Thyroid Hormones C0040135
DISO_to_DISO98img Congenital Hypothyroidism C0010308
DISO_to_CHEM76img B30-B31 THYROID HORMONES C0040135
DISO_to_CHEM71img Triiodothyronine C0041014
DISO_to_CHEM64img Iodine C0021968
DISO_to_DISO64img Pregnancy Complications C0032962
DISO_to_CHEM60img Triiodothyronine C0041014
Genes (52)

Species:
human : 52
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanIYD389434iodotyrosine deiodinase
img GENERIF, Score=861, Pubmed Id: 18434651, UMLKSK CUI: C0020676
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanUBR1197131ubiquitin protein ligase E3 component n-recognin 1
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanKISS1R84634KISS1 receptor
img OMIM, Score=833, UMLKSK CUI: C0020676
HumanFOXP350943forkhead box P3
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanDUOX250506dual oxidase 2
INFERRED, Score=800, UMLKSK CUI: C0020676
HumanLHX38022LIM homeobox 3
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanPAX87849paired box 8
INFERRED, Score=800, UMLKSK CUI: C0020676
HumanALMS17840Alstrom syndrome 1
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanWFS17466Wolfram syndrome 1 (wolframin)
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTSHR7253thyroid stimulating hormone receptor
INFERRED, Score=800, UMLKSK CUI: C0020676
HumanTSHB7252thyroid stimulating hormone, beta
img GAD, Score=1000, Pubmed Id: 15297803, UMLKSK CUI: C0020676
img GAD, Score=1000, Pubmed Id: 12364478, UMLKSK CUI: C0020676
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTSC27249tuberous sclerosis 2
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTSC17248tuberous sclerosis 1
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTPO7173thyroid peroxidase
img GENERIF, Score=1000, Pubmed Id: 15562032, UMLKSK CUI: C0020676
img GENERIF, Score=1000, Pubmed Id: 19189706, UMLKSK CUI: C0020676
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTNF7124tumor necrosis factor
img GAD, Score=1000, Pubmed Id: 15236755, UMLKSK CUI: C0020676
HumanNKX2-17080
img OMIM, Score=1000, UMLKSK CUI: C0020676
img GENERIF, Score=1000, Pubmed Id: 18788921, UMLKSK CUI: C0020676
HumanTG7038thyroglobulin
img GENERIF, Score=1000, Pubmed Id: 18631008, UMLKSK CUI: C0020676
img GENERIF, Score=1000, Pubmed Id: 15769978, UMLKSK CUI: C0020676
HumanTBX16899T-box 1
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanSLC16A26567solute carrier family 16, member 2 (thyroid hormone transporter)
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanSLC5A56528solute carrier family 5 (sodium/iodide cotransporter), member 5
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanCCL26347chemokine (C-C motif) ligand 2
img GENERIF, Score=694, Pubmed Id: 15745922, UMLKSK CUI: C0020676
HumanSALL16299sal-like 1 (Drosophila)
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanPTEN5728phosphatase and tensin homolog
img OMIM, Score=1000, UMLKSK CUI: C0020676
HumanTAS2R385726taste receptor, type 2, member 38
INFERRED, Score=800, UMLKSK CUI: C0020676
HumanPMM25373phosphomannomutase 2
img OMIM, Score=1000, UMLKSK CUI: C0020676
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020676Hypothyroidism0self