GATACA

Credits

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Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Hypopituitarism

Debug Stats

### Total Build Time: 130 ms 38.210 KB
CONCEPT_NAME gt=18 ms Completed: 18 ms rowSize= 328 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 541 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 554 bytes
CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 557 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.794 KB
CONCEPT_RELATIONSHIPS gt=87 ms Completed: 87 ms rowSize= 13.836 KB
CONCEPT_GENES gt=13 ms Completed: 13 ms rowSize= 18.286 KB
CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.149 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Hypopituitarism C0020635

Definition (1)

diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including luteinizing hormone, follicle stimulating hormone, somatotropin; and corticotropin); may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Semantic Types (1)

Disease or Syndrome (T047)

Parents (1)

C0032002

Children (1)

C0013338

Ancestral Roots

Root	Root Plus One	Depth	Parent
Nervous System Diseases C0027765	Central Nervous System Diseases C0007682	6	Pituitary Diseases C0032002
Endocrine System Diseases C0014130	Pituitary Diseases C0032002	3	Pituitary Diseases C0032002

Relationships (80)

Relation Types:

diso_to_anat : 8

diso_to_chem : 18

diso_to_diso : 51

diso_to_phen : 2

diso_to_phys : 1

Relationships:

none : 45

associated_with : 2

entry_version_of : 1

is_primary_anatomic_site_of_disease : 1

isa : 21

location_of : 1

mapped_to : 8

use : 1

Page Size

Current 25

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Prior Page

Current 1

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_DISO	138		Complication Aspects C1171258
DISO_to_DISO	135		Complication Aspects C1171258
DISO_to_CHEM	123		Human Growth Hormone C0169964
DISO_to_CHEM	113		Human Growth Hormone C0169964
DISO_to_ANAT	91		In Blood C0005768
DISO_to_ANAT	79		In Blood C0005768
DISO_to_PHEN	77		genetic aspects C0017399
DISO_to_DISO	59		Brain Injuries C0270611
DISO_to_ANAT	56		Pituitary Gland C0032005
DISO_to_CHEM	50		Growth Hormone C0037663
DISO_to_DISO	48		Brain Injuries C0270611
DISO_to_DISO	46		Pituitary Neoplasms C0032019
DISO_to_PHEN	37		genetic aspects C0017399
DISO_to_CHEM	36		Pituitary Hormones C0032015
DISO_to_ANAT	29		Pituitary Gland C0032005
DISO_to_CHEM	29		Homeo Domain Proteins C0242617
DISO_to_CHEM	29		Homeodomain Proteins C0242617
DISO_to_DISO	25		Pituitary Neoplasms C0032019
DISO_to_CHEM	22		Growth Hormone C0037663
DISO_to_CHEM	18		TRANSCRIPTION FACTOR C0040648
DISO_to_CHEM	18		Transcription Factors C0040648
DISO_to_DISO	18		Adenoma C0001430
DISO_to_DISO	18		Adrenal Insufficiency C0001623
DISO_to_ANAT	15		Pituitary Gland, Anterior C0032008
DISO_to_CHEM	15		Homeo Domain Proteins C0242617

Genes (21)

Species:

human : 21

Species	Gene	GeneId	Gene Name	Evidence
Human	LIPI	149998	lipase, member I	OMIM, Score=1000, UMLKSK CUI: C0020635 Phenotype environmentally influenced, esp. by carbohydrate and ethanol consumption, uremia, hypopituitarism, contraceptive steroids, and glycogen storage disease I
Human	APOA5	116519	apolipoprotein A-V	OMIM, Score=1000, UMLKSK CUI: C0020635 Phenotype environmentally influenced, esp. by carbohydrate and ethanol consumption, uremia, hypopituitarism, contraceptive steroids, and glycogen storage disease I
Human	CSMD3	114788	CUB and Sushi multiple domains 3	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	LHX4	89884	LIM homeobox 4	GENERIF, Score=861, Pubmed Id: 18445675, UMLKSK CUI: C0020635 three new exonic LHX4 allelic variants with at least one being responsible for congenital hypopituitarism
Human	PREPL	9581	prolyl endopeptidase-like	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	HESX1	8820	HESX homeobox 1	GENERIF, Score=1000, Pubmed Id: 17148560, UMLKSK CUI: C0020635 Mutations within HESX1 are a rare cause of septooptic dysplasia and hypopituitarism
Human	SOX3	6658	SRY (sex determining region Y)-box 3	GENERIF, Score=1000, Pubmed Id: 15800844, UMLKSK CUI: C0020635 We conclude that both over- and underdosage of SOX3 are associated with similar phenotypes, consisting of infundibular hypoplasia and hypopituitarism but not necessarily MR
Human	SIX3	6496	SIX homeobox 3	OMIM, Score=1000, UMLKSK CUI: C0020635 Pituitary deficiency
Human	SHH	6469	sonic hedgehog	OMIM, Score=1000, UMLKSK CUI: C0020635 Hypopituitarism
Human	SRSF2	6427	serine/arginine-rich splicing factor 2	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	SRSF1	6426	serine/arginine-rich splicing factor 1	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	RP1	6101	retinitis pigmentosa 1 (autosomal dominant)	OMIM, Score=1000, UMLKSK CUI: C0020635 Phenotype environmentally influenced, esp. by carbohydrate and ethanol consumption, uremia, hypopituitarism, contraceptive steroids, and glycogen storage disease I
Human	PROP1	5626	PROP paired-like homeobox 1	GENERIF, Score=1000, Pubmed Id: 12717343, UMLKSK CUI: C0020635 PROP-1 which is required for generation of hormone producing cells in the anterior pituitary gland, have proved to be important in the cause of hypopituitarism in humans-- REVIEW
Human	POU1F1	5449	POU class 1 homeobox 1	GENERIF, Score=1000, Pubmed Id: 12717343, UMLKSK CUI: C0020635 Pit-1 which is required for generation of hormone producing cells in the anterior pituitary gland, have proved to be important in the cause of hypopituitarism in humans--REVIEW GENERIF, Score=901, Pubmed Id: 15928241, UMLKSK CUI: C0020635 the phenotype associated with POU1F1 mutations may be more variable, with the occasional preservation of TSH secretion in pituitary deficiency disease
Human	LEP	3952	leptin	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	IGF1	3479	insulin-like growth factor 1 (somatomedin C)	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	GLI3	2737	GLI family zinc finger 3	OMIM, Score=1000, UMLKSK CUI: C0020635 Hypopituitarism
Human	GLI2	2736	GLI family zinc finger 2	GENERIF, Score=861, Pubmed Id: 14581620, UMLKSK CUI: C0020635 GLI2 has a role in defective anterior pituitary formation and pan-hypopituitarism, and in human head development
Human	GHR	2690	growth hormone receptor	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	GH1	2688	growth hormone 1	INFERRED, Score=800, UMLKSK CUI: C0020635
Human	BMP4	652	bone morphogenetic protein 4	OMIM, Score=1000, UMLKSK CUI: C0020635 Hypopituitarism

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0020635	Hypopituitarism	0		self

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