Human | FTO | 79068 | fat mass and obesity associated | Association of FTO single nucleotide polymorphism(SNP) to fatness throughout the range of fatness was confirmed, explaininng the relation between the SNP and body fat distribution and decreased insulin sensitivity |
Human | WNK1 | 65125 | WNK lysine deficient protein kinase 1 | Impaired sensation in distal extremities (pain, temperature, position, touch) |
Human | CDKAL1 | 54901 | CDK5 regulatory subunit associated protein 1-like 1 | CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | women with polycystic ovary syndrome had lower fasting ghrelin and decreased insulin sensitivity independently of their body mass index |
Human | IKBKAP | 8518 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein | Decreased sensitivity to hypoxemia |
Human | TRPV1 | 7442 | transient receptor potential cation channel, subfamily V, member 1 | IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system |
Human | RYR3 | 6263 | ryanodine receptor 3 | smooth muscle RYR3 may function as a suppressor of RyR2-mediated Ca2+ release by forming heteromeric channels with a decreased sensitivity to activation by luminal Ca2+ |
Human | OGG1 | 4968 | 8-oxoguanine DNA glycosylase | The OGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance |
Human | NTRK1 | 4914 | neurotrophic tyrosine kinase, receptor, type 1 | Accidental injury and ulceration of the lips and tongue due to decreased sensation |
Human | NGF | 4803 | nerve growth factor (beta polypeptide) | Accidental injury and ulceration of the lips and tongue due to decreased sensation |
Human | LIFR | 3977 | leukemia inhibitory factor receptor alpha | Ulcers of the tongue due to decreased sensation |
Human | INSR | 3643 | insulin receptor | Results led to a conclusion that the novel T/C SNP at codon Cys1008 of INSR is associated with decreased insulin sensitivity in Chinese women with polycystic ovary syndrome |
Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system |
Human | GJB1 | 2705 | gap junction protein, beta 1, 32kDa | |
Human | FGFR2 | 2263 | fibroblast growth factor receptor 2 | Corneal sensitivity impairment (hypesthesia) |
Human | FGFR3 | 2261 | fibroblast growth factor receptor 3 | Corneal sensitivity impairment (hypesthesia) |
Human | FGF10 | 2255 | fibroblast growth factor 10 | Corneal sensitivity impairment (hypesthesia) |
Human | F10 | 2159 | coagulation factor X | FVIIa not only decreased thromboplastin sensitivity to plasma FVII, it surprisingly increased sensitivity to plasma levels of FV, FX and prothrombin |
Human | SERPING1 | 710 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | Impaired sensation of all modalities, distal |
Human | BCR | 613 | breakpoint cluster region | BCR-ABL deletion mutants lacking kinase domain is associated with decreased drug sensitivity in patients with chronic myeloid leukemia |