Human | GPIHBP1 | 338328 | glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 | a very rare GPIHBP1 missense mutation appears to be associated with severe hypertriglyceridemia and chylomicronemia |
Human | LIPI | 149998 | lipase, member I | |
Human | APOA5 | 116519 | apolipoprotein A-V | Click here to display 16 evidence detail records. |
Human | ANGPTL4 | 51129 | angiopoietin-like 4 | triglyceride concentration differences among adipokine angiopoietin-like 4 (ANGPTL4[E40K]) A allele carriers and G allele homozygotes are maintained over time; degree of triglyceride increase was similar between groups and not modified by weight changes |
Human | BSCL2 | 26580 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | |
Human | AGPAT2 | 10555 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Fenofibrate improved percent flow-mediated dilator response to hyperemia, reduced inflammation marker levels, increased adiponectin levels, and improved insulin sensitivity in hypertriglyceridemic or metabolic syndrome patients |
Human | ALMS1 | 7840 | Alstrom syndrome 1 | |
Human | VWF | 7450 | von Willebrand factor | In hypertriglyceridemia VWF elevation is a result of endothelial activation and subsequent mobilization of VWF from the arterial wall |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Patients withprimary hypertriglyceridemia as compared with control subjects showed significantly higher VCAM-1 (vascular cell adhesion molecule 1) |
Human | SLC10A2 | 6555 | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | INFERRED, Score=800, UMLKSK CUI: C0020557 |
Human | SCD | 6319 | stearoyl-CoA desaturase (delta-9-desaturase) | stearoyl-CoA desaturase influence on plasma triglycerides in hypertriglyceridemia |
Human | RP1 | 6101 | retinitis pigmentosa 1 (autosomal dominant) | Title:Hypertriglyceridemia associated with amino acid variation Asn985Tyr of the RP1 gene|Association:Y|Conclusion:Although this SNP marker may itself be in linkage disequilibrium with other unexamined functional variants within this locus, our data suggest that genetic variation at the RP1 locus is one of the likely candidate determinants for plasma triglyceride and HDL-cholesterol metabolisms. |
Human | PLTP | 5360 | phospholipid transfer protein | elevated PLTP activity in hypertriglyceridemia is related to insulin resistance and not to increased PLTP mass |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E |
Human | NPY5R | 4889 | neuropeptide Y receptor Y5 | single nucleotide polymorphisms in the NPY5R gene may have a role in dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in Mexican Americans |
Human | MTTP | 4547 | microsomal triglyceride transfer protein | FoxO1 mediates insulin regulation of MTP production and augmented MTP levels may be a causative factor for VLDL overproduction and hypertriglyceridemia in diabetes |
Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | classical risk factors such as smoking, hypertension, low alcohol intake and elevated triglyceride concentration were relatively more important for development of CPAD than MBL deficiency in SLE |
Human | LPL | 4023 | lipoprotein lipase | Title:Severe hypertriglyceridaemia in Type II diabetes:involvement of apoC-III Sst-I polymorphism, LPL mutations and apo E3 deficiency.|Association:Not Found|Conclusion:Our results strongly support the hypothesis that severe hyperlipaemia in Type II diabetes crucially depends on genetic factors which impair the clearance of triglyceride-rich lipoproteins. LPL-deficient subjects with hypertriglyceridemia displayed an enhanced glucose-stimulated insulin response as well as lower blood glucose levels These results reveal the importance of genetic screening for LPL gene mutations D9N and S447X in a population at risk to develop hypertriglyceridemia Novel mutations of the LPL gene contribute to the hypertriglyceridemia observed in members of type 2 diabetic pedigrees Title:|Association:Y|Conclusion:Not Found Early recognition of severe hypertriglyceridemia in pregnancy may be caused by heterozygosity of this enzyme p.N318S is a major predisposing factor to hypertriglyceridaemia in the Northern Irish population TRL-bound LPL activity increases in the postprandial state and is strongly reduced in type 2 diabetes, contributing to postprandial hypertriglyceridemia Both common and rare DNA variants of lipoprotein lipase (LPL) gene were found in 10% patients with severe hypertriglyceridemia |
Human | GK | 2710 | glycerol kinase | missense mutations and deletions in glycerol kinase is associated with persistent hypertriglyceridemia |
Human | FOXO1 | 2308 | forkhead box O1 | FoxO1 mediates insulin regulation of MTP production and augmented MTP levels may be a causative factor for VLDL overproduction and hypertriglyceridemia in diabetes |
Human | FABP2 | 2169 | fatty acid binding protein 2, intestinal | the effects of FABP2 allelic variations may play roles in cardiovascular pathogenesis in the presence of insulin resistance or hypertriglyceridemia |
Human | ACE | 1636 | angiotensin I converting enzyme | ACE polymorphism was associated with hypertriglyceridemia |
Human | CETP | 1071 | cholesteryl ester transfer protein, plasma | a rationale to evaluate the effects of CETP inhibitor treatment on plasma cholesterol ester transfer and on cardiovascular risk in diabetes-associated hypertriglyceridemia |
Human | CD36 | 948 | CD36 molecule (thrombospondin receptor) | Defects in CD36 have been linked to the hypertriglyceridemia and insulin resistance; this study using a rat model suggests that plasma glucose levels are more important in the regulation of expression than plasma insulin |