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Details
Link-It Detail - Disease - Hyperthyroidism
Debug Stats
  • ### Total Build Time: 308 ms 42.470 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 328 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 583 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=12 ms Completed: 12 ms rowSize= 552 bytes
  • CONCEPT_CHILDREN gt=10 ms Completed: 10 ms rowSize= 984 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.505 KB
  • CONCEPT_RELATIONSHIPS gt=224 ms Completed: 224 ms rowSize= 15.276 KB
  • CONCEPT_GENES gt=50 ms Completed: 50 ms rowSize= 21.938 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.149 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Hyperthyroidism C0020550
Definition (1)
Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Thyroid Diseases C0040128
Children (2)
img Graves Disease C0018213
img Thyrotoxicosis C0040156
Ancestral Roots
RootRoot Plus OneDepthParent
img Endocrine System Diseases C0014130img Thyroid Diseases C00401283img Thyroid Diseases C0040128
Relationships (122)

Relation Types:
diso_​to_​anat : 16
diso_​to_​chem : 41
diso_​to_​diso : 55
diso_​to_​gene : 4
diso_​to_​phen : 2
diso_​to_​phys : 4


Relationships:
none : 83
associated_​with : 1
disease_​has_​associated_​disease : 1
disease_​may_​have_​finding : 1
gene_​associated_​with_​disease : 4
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​associated_​anatomic_​site_​of : 3
is_​normal_​tissue_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 10
mapped_​to : 7
may_​treat : 9
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO285img Complication Aspects C1171258
DISO_to_DISO267img Complication Aspects C1171258
DISO_to_ANAT184img In Blood C0005768
DISO_to_DISO181img HYPOTHYROIDISM C0020676
DISO_to_DISO175img HYPOTHYROIDISM C0020676
DISO_to_ANAT165img In Blood C0005768
DISO_to_DISO108img chemically induced C0007994
DISO_to_CHEM89img Iodine Radioisotopes C0021970
DISO_to_DISO81img chemically induced C0007994
DISO_to_CHEM79img Antithyroid Agents C0040125
DISO_to_CHEM75img Iodine Radioisotopes C0021970
DISO_to_CHEM69img Antithyroid Agents C0040125
DISO_to_ANAT56img Thyroid Gland C0040132
DISO_to_ANAT54img Thyroid Gland C0040132
DISO_to_DISO52img CAT DIS C0007350
DISO_to_DISO47img CAT DIS C0007350
DISO_to_PHEN45img genetic aspects C0017399
DISO_to_CHEM44img Thyrotropin C0040160
DISO_to_CHEM43img Thyroxine C0040165
DISO_to_CHEM42img Thyrotropin C0040160
DISO_to_DISO42img Thyroid Neoplasms C0040136
DISO_to_CHEM41img B30-B31 THYROID HORMONES C0040135
DISO_to_CHEM41img Thyroid Hormones C0040135
DISO_to_CHEM41img Thyroxine C0040165
DISO_to_PHEN40img genetic aspects C0017399
Genes (105)

Species:
human : 105
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanGRDX117189Graves disease, susceptibility to, X-linked
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanSCGB3A2117156secretoglobin, family 3A, member 2
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanFCRL3115352Fc receptor-like 3
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanIFIH164135interferon induced with helicase C domain 1
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanRETN56729resistin
img GENERIF, Score=1000, Pubmed Id: 16061827, UMLKSK CUI: C0020550
HumanUACA55075uveal autoantigen with coiled-coil domains and ankyrin repeats
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanGRD250976Graves disease, susceptibility to, 2
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanCD27429126CD274 molecule
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanPTPN2226191protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanPRDX525824peroxiredoxin 5
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanCXCR610663chemokine (C-X-C motif) receptor 6
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanADIPOQ9370adiponectin, C1Q and collagen domain containing
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanPAX87849paired box 8
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
img GAD, Score=1000, Pubmed Id: 11028447, UMLKSK CUI: C0020550
HumanTNFRSF47293tumor necrosis factor receptor superfamily, member 4
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTSHR7253thyroid stimulating hormone receptor
img OMIM, Score=1000, UMLKSK CUI: C0020550
img GENERIF, Score=1000, Pubmed Id: 18528812, UMLKSK CUI: C0020550
img GENERIF, Score=861, Pubmed Id: 16756474, UMLKSK CUI: C0020550
img GENERIF, Score=1000, Pubmed Id: 12813025, UMLKSK CUI: C0020550
HumanTPO7173thyroid peroxidase
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTNFRSF1B7133tumor necrosis factor receptor superfamily, member 1B
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTNF7124tumor necrosis factor
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTHY17070Thy-1 cell surface antigen
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTHRB7068thyroid hormone receptor, beta
img OMIM, Score=1000, UMLKSK CUI: C0020550
HumanTGFB17040transforming growth factor, beta 1
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTG7038thyroglobulin
img GENERIF, Score=861, Pubmed Id: 17550957, UMLKSK CUI: C0020550
HumanTAP26891transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
INFERRED, Score=800, UMLKSK CUI: C0020550
HumanTAP16890transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
INFERRED, Score=800, UMLKSK CUI: C0020550
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020550Hyperthyroidism0self