Logo arc image image
GATACA
  • Pin/Unpin Search
  • Pin/Unpin Details
Status:
Global Actions
Concepts: 0 (0)   Selected: 0 (0
Clear All Selections
 
Search
Text Search Results
Text Search Query:
none
Text Search Options:
none

Guided Help

Text Search Results
GraphTree Minimize or Maximize this Category
 Disease: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Anatomy: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Gene: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Jax Mouse Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Human Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Biological Processes: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Cellular Component: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Molecular Function: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Pathway: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Drug: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Genomic Expression Atlas --
      Microarray Datasets: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 PubMed: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 CoExpression Atlas: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 CoExpression: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Interactions: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Details
Link-It Detail - Disease - Hypertension, Pulmonary
Debug Stats
  • ### Total Build Time: 601 ms 50.895 KB
  • CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 344 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.240 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=22 ms Completed: 22 ms rowSize= 549 bytes
  • CONCEPT_CHILDREN gt=12 ms Completed: 12 ms rowSize= 575 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.500 KB
  • CONCEPT_RELATIONSHIPS gt=509 ms Completed: 509 ms rowSize= 14.671 KB
  • CONCEPT_GENES gt=41 ms Completed: 41 ms rowSize= 30.682 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.157 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Hypertension, Pulmonary C0020542
Definition (1)

Pulmonary hypertension is high blood pressure in the arteries to your lungs. It is a serious condition for which there are treatments but no cure. If you have it, the blood vessels that carry oxygen-poor blood from your heart to your lungs become hard and narrow. Your heart has to work harder to pump the blood through. Over time, your heart weakens and cannot do its job and you can develop heart failure.

There are two main kinds of pulmonary hypertension. One runs in families or appears for no known reason. The other kind is related to another condition, usually heart or lung disease.

Treating pulmonary hypertension involves treating the heart or lung disease, medicines, oxygen and sometimes lung transplantation.

NIH: National Heart, Lung, and Blood Institute

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Lung Diseases C0024115
Children (1)
img Persistent Fetal Circulation Syndrome C0031190
Ancestral Roots
RootRoot Plus OneDepthParent
img Respiratory Tract Diseases C0035242img Lung Diseases C00241153img Lung Diseases C0024115
Relationships (255)

Relation Types:
diso_​to_​anat : 16
diso_​to_​chem : 132
diso_​to_​diso : 79
diso_​to_​gene : 2
diso_​to_​phen : 2
diso_​to_​phys : 24


Relationships:
none : 158
clinically_​similar : 1
entry_​version_​of : 1
gene_​associated_​with_​disease : 2
isa : 9
mapped_​to : 5
may_​treat : 78
related_​to : 1
Page Size
Current 25
  Page 1 of 11
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO737img Complication Aspects C1171258
DISO_to_ANAT522img Pulmonary Artery C0034052
DISO_to_CHEM425img Antihypertensive Agents C0003364
DISO_to_DISO407img Complication Aspects C1171258
DISO_to_ANAT321img Pulmonary Artery C0034052
DISO_to_CHEM302img Antihypertensive Agents C0003364
DISO_to_CHEM280img 815-816 VASODILATING AGENTS C0042402
DISO_to_CHEM277img 815-816 VASODILATING AGENTS C0042402
DISO_to_PHEN270img genetic aspects C0017399
DISO_to_DISO254img chemically induced C0007994
DISO_to_DISO241img Pulmonary Embolism C0034065
DISO_to_ANAT234img In Blood C0005768
DISO_to_CHEM220img Piperazines C0031958
DISO_to_CHEM207img Piperazines C0031958
DISO_to_CHEM203img Sulfones C0038761
DISO_to_DISO195img Heart Failure C0018801
DISO_to_DISO194img Anoxia C0003130
DISO_to_CHEM191img Epoprostenol C0033567
DISO_to_DISO185img Scleroderma, Systemic C0036421
DISO_to_DISO183img Anoxia C0003130
DISO_to_PHEN179img genetic aspects C0017399
DISO_to_CHEM174img Sulfonamides C0038760
DISO_to_ANAT170img Lung C0024109
DISO_to_DISO166img Pulmonary Embolism C0034065
DISO_to_DISO164img DYSFUNCTION, RIGHT VENTRICULAR C0242707
Genes (34)

Species:
human : 34
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanUTS2D257313
img GENERIF, Score=1000, Pubmed Id: 18000598, UMLKSK CUI: C0020542
HumanNOX450507NADPH oxidase 4
img GENERIF, Score=1000, Pubmed Id: 17585072, UMLKSK CUI: C0020542
HumanGREM126585gremlin 1, DAN family BMP antagonist
img GENERIF, Score=1000, Pubmed Id: 18469115, UMLKSK CUI: C0020542
HumanUTS210911urotensin 2
img GENERIF, Score=1000, Pubmed Id: 15618545, UMLKSK CUI: C0020542
HumanLYVE110894lymphatic vessel endothelial hyaluronan receptor 1
INFERRED, Score=800, UMLKSK CUI: C0020542
HumanARHGEF69459Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
img GENERIF, Score=1000, Pubmed Id: 15242552, UMLKSK CUI: C0020542
HumanPLA2G77941phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
img GENERIF, Score=861, Pubmed Id: 17509958, UMLKSK CUI: C0020542
HumanVWF7450von Willebrand factor
img GENERIF, Score=673, Pubmed Id: 14507115, UMLKSK CUI: C0020542
HumanAVSD17446atrioventricular septal defect 1
img OMIM, Score=1000, UMLKSK CUI: C0020542
HumanTRPC67225transient receptor potential cation channel, subfamily C, member 6
img GENERIF, Score=734, Pubmed Id: 15358862, UMLKSK CUI: C0020542
HumanTNF7124tumor necrosis factor
INFERRED, Score=800, UMLKSK CUI: C0020542
HumanTGFA7039transforming growth factor, alpha
img GENERIF, Score=1000, Pubmed Id: 12896876, UMLKSK CUI: C0020542
HumanSLC6A46532solute carrier family 6 (neurotransmitter transporter), member 4
img GENERIF, Score=1000, Pubmed Id: 14530202, UMLKSK CUI: C0020542
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 12391278, UMLKSK CUI: C0020542
HumanPPARG5468peroxisome proliferator-activated receptor gamma
img GENERIF, Score=1000, Pubmed Id: 18317434, UMLKSK CUI: C0020542
img GENERIF, Score=861, Pubmed Id: 12714563, UMLKSK CUI: C0020542
img GENERIF, Score=1000, Pubmed Id: 18382765, UMLKSK CUI: C0020542
HumanNPPB4879natriuretic peptide B
img GENERIF, Score=1000, Pubmed Id: 16236896, UMLKSK CUI: C0020542
img GENERIF, Score=1000, Pubmed Id: 18160811, UMLKSK CUI: C0020542
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
img GAD, Score=1000, Pubmed Id: 14682408, UMLKSK CUI: C0020542
HumanNOS24843nitric oxide synthase 2, inducible
img GENERIF, Score=1000, Pubmed Id: 16456243, UMLKSK CUI: C0020542
HumanJUN3725jun proto-oncogene
img GENERIF, Score=861, Pubmed Id: 12909593, UMLKSK CUI: C0020542
HumanTNC3371tenascin C
img GENERIF, Score=660, Pubmed Id: 16782755, UMLKSK CUI: C0020542
HumanGJA12697gap junction protein, alpha 1, 43kDa
img OMIM, Score=1000, UMLKSK CUI: C0020542
HumanGBA2629glucosidase, beta, acid
img OMIM, Score=1000, UMLKSK CUI: C0020542
HumanSLC37A42542solute carrier family 37 (glucose-6-phosphate transporter), member 4
img OMIM, Score=1000, UMLKSK CUI: C0020542
HumanFLNA2316filamin A, alpha
img OMIM, Score=1000, UMLKSK CUI: C0020542
HumanEDN11906endothelin 1
img GENERIF, Score=1000, Pubmed Id: 17291632, UMLKSK CUI: C0020542
img GENERIF, Score=861, Pubmed Id: 15979050, UMLKSK CUI: C0020542
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020542Hypertension, Pulmonary0self