Human | UTS2D | 257313 | | vascular remodelling processes in conjunction with enhanced vasoconstriction are involved in the pathogenesis of pulmonary hypertension; UII may play a novel role in the pathogenesis of this disorder |
Human | NOX4 | 50507 | NADPH oxidase 4 | In lungs from patients with idiopathic pulmonary arterial hypertension, NOX4 expression in the tunica media was 2.5-fold upregulated, supporting an important role for NOX4 in the vascular remodeling associated with pulmonary hypertension |
Human | GREM1 | 26585 | gremlin 1, DAN family BMP antagonist | the mechanisms of pulmonary hypertension and vascular loss in chronic lung disease and identifies gremlin 1 as a potentially important mediator of vascular changes in hypoxic pulmonary hypertension |
Human | UTS2 | 10911 | urotensin 2 | hU-II may play a novel role in pulmonary hypertension by promoting remodeling processes via activation of NADPH oxidases |
Human | LYVE1 | 10894 | lymphatic vessel endothelial hyaluronan receptor 1 | INFERRED, Score=800, UMLKSK CUI: C0020542 |
Human | ARHGEF6 | 9459 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | The increased values of VEGF, PLA2-LDL and P-selectin in patients with long standing pulmonary hypertension are related to severe endothelial dysfunction and may have prognostic values |
Human | VWF | 7450 | von Willebrand factor | data suggest a common mechanism for platelet and vWF abnormalities in these chronically hypoxic pulmonary hypertension patients |
Human | AVSD1 | 7446 | atrioventricular septal defect 1 | |
Human | TRPC6 | 7225 | transient receptor potential cation channel, subfamily C, member 6 | TRPC channel overexpression may be partially responsible for the increased pulmonary artert smooth muscle cell proliferation and pulmonary vascular medial hypertrophy in pulmonary hypertension patients |
Human | TNF | 7124 | tumor necrosis factor | INFERRED, Score=800, UMLKSK CUI: C0020542 |
Human | TGFA | 7039 | transforming growth factor, alpha | Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing human transforming growth factor-alpha |
Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | 5-HTT gene polymorphism appears to determine the severity of pulmonary hypertension in hypoxemic patients with COPD |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPARgamma expression is reduced or lacking in all of the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe PH (pulmonary hypertension) Results describe an antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension Peroxisome proliferator-activated receptor gamma is expressed in the lung and pulmonary vasculature, and its expression is reduced in the vascular lesions of patients with pulmonary hypertension |
Human | NPPB | 4879 | natriuretic peptide B | Pulmonary hypertension is associated with NT-proBNP elevation and diastolic impairment in congenital diaphragmatic hernia infants BNP levels parallel changes in pulmonary hemodynamics and functional parameters in pulmonary hypertension |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD.|Association:Y|Conclusion:In conclusion, BB-type polymorphism of the eNOS gene has been associated with PH in addition to hypoxemia. However, ACE gene polymorphism was not found to be associated with PH. |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | The observed decrease in pulmonary expression of iNOS in patients with CDH suggests a potential role in the pathogenesis of pulmonary hypertension in newborns with congenital diaphragmatic hernia |
Human | JUN | 3725 | jun proto-oncogene | The Ca2+-mediated increase in AP-1 binding may play an important role in upregulating AP-1-responsive gene expression, in stimulating pulmonary vascular cell proliferation and in pulmonary vascular remodeling in hypoxia-mediated pulmonary hypertension |
Human | TNC | 3371 | tenascin C | Link between BMPR2 mutations and induction of Prx 1-dependent tenascin-c gene transcription in familial pulmonary hypertension smooth muscle cells |
Human | GJA1 | 2697 | gap junction protein, alpha 1, 43kDa | |
Human | GBA | 2629 | glucosidase, beta, acid | |
Human | SLC37A4 | 2542 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | |
Human | FLNA | 2316 | filamin A, alpha | |
Human | EDN1 | 1906 | endothelin 1 | Assessment of ET plasmatic levels for detection and monitoring of pulmonary hypertension during systemic sclerosis is warranted in larger prospective studies These data suggest that secreted HIV gp120 proteins induce lung endothelial cell injury and could contribute to the development of HIV-associated pulmonary hypertension |