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Details
Link-It Detail - Disease - Hypersensitivity, Immediate
Debug Stats
  • ### Total Build Time: 280 ms 41.019 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 408 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 894 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=11 ms Completed: 11 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 552 bytes
  • CONCEPT_CHILDREN gt=24 ms Completed: 24 ms rowSize= 3.108 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.502 KB
  • CONCEPT_RELATIONSHIPS gt=163 ms Completed: 163 ms rowSize= 15.213 KB
  • CONCEPT_GENES gt=74 ms Completed: 74 ms rowSize= 18.013 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.161 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Hypersensitivity, Immediate C0020523
Immediate hypersensitivity
Definition (1)
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
Semantic Types (1)
Pathologic Function (T046)
Parents (1)
img Hypersensitivity C0020517
Children (7)
img Conjunctivitis, Allergic C0009766
img Anaphylaxis C0002792
img Dermatitis, Atopic C0011615
img Urticaria C0042109
img Respiratory Hypersensitivity C0035228
img Food Hypersensitivity C0016470
img Asthma, Aspirin-Induced C1319853
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Hypersensitivity C00205173img Hypersensitivity C0020517
Relationships (132)

Relation Types:
diso_​to_​anat : 11
diso_​to_​chem : 57
diso_​to_​diso : 53
diso_​to_​gene : 1
diso_​to_​phen : 3
diso_​to_​phys : 7


Relationships:
none : 89
induces : 21
isa : 6
mapped_​to : 1
may_​diagnose : 4
may_​prevent : 1
may_​treat : 4
negatively_​regulates : 1
positively_​regulates : 1
regulates : 1
related_​to : 1
use : 1
used_​for : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO216img Asthma C0004096
DISO_to_DISO206img Asthma C0004096
DISO_to_CHEM188img Allergens C0002092
DISO_to_CHEM160img Allergens C0002092
DISO_to_CHEM141img Immunoglobulin E C0020846
DISO_to_PHEN136img genetic aspects C0017399
DISO_to_CHEM124img Immunoglobulin E C0020846
DISO_to_PHEN122img genetic aspects C0017399
DISO_to_DISO99img Drug Allergy C0013182
DISO_to_DISO98img chemically induced C0007994
DISO_to_DISO95img Complication Aspects C1171258
DISO_to_DISO86img Complication Aspects C1171258
DISO_to_ANAT79img In Blood C0005768
DISO_to_ANAT70img In Blood C0005768
DISO_to_DISO57img Drug Allergy C0013182
DISO_to_DISO47img Delayed Hypersensitivity C0020522
DISO_to_DISO45img chemically induced C0007994
DISO_to_DISO44img Food Allergy C0016470
DISO_to_DISO37img Insect Bites and Stings C0021568
DISO_to_DISO37img Latex Hypersensitivity C0577628
DISO_to_DISO33img Food Allergy C0016470
DISO_to_PHYS32img Respiratory Sounds C0035234
DISO_to_DISO30img Delayed Hypersensitivity C0020522
DISO_to_CHEM28img Apidae venom C0004920
DISO_to_ANAT27img T-helper cell type 2 C0242633
Genes (366)

Species:
human : 366
Page Size
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SpeciesGeneGeneIdGene NameEvidence
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanMUC5B727897mucin 5B, oligomeric mucus/gel-forming
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanSFTPA1653509surfactant protein A1
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanNPS594857neuropeptide S
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanGTF2H5404672general transcription factor IIH, polypeptide 5
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanNPSR1387129neuropeptide S receptor 1
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanIL31386653interleukin 31
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanTRG@281523
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanCOL6A5256076collagen, type VI, alpha 5
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanIL27246778interleukin 27
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanATOD5117188Dermatitis, atopic, 5
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanATOD3117187Dermatitis, atopic, 3
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanDCD117159dermcidin
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanSCGB3A2117156secretoglobin, family 3A, member 2
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanRASGRP4115727RAS guanyl releasing protein 4
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanATOD6114477Dermatitis, atopic, 6
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanIL17F112744interleukin 17F
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanORMDL394103ORM1-like 3 (S. cerevisiae)
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanIL3390865interleukin 33
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanTSLP85480thymic stromal lymphopoietin
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanHAVCR284868hepatitis A virus cellular receptor 2
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanITCH83737itchy E3 ubiquitin protein ligase
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanTLR1081793toll-like receptor 10
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanADAM3380332ADAM metallopeptidase domain 33
INFERRED, Score=800, UMLKSK CUI: C0020523
HumanADM279924adrenomedullin 2
INFERRED, Score=800, UMLKSK CUI: C0020523
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020523Hypersensitivity, Immediate0self