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Details
Link-It Detail - Disease - Hyperparathyroidism
Debug Stats
  • ### Total Build Time: 92 ms 43.064 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 392 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.809 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=7 ms Completed: 7 ms rowSize= 556 bytes
  • CONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 1,014 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.513 KB
  • CONCEPT_RELATIONSHIPS gt=69 ms Completed: 69 ms rowSize= 13.819 KB
  • CONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 22.644 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Hyperparathyroidism C0020502
HPTH - Hyperparathyroidism
Definition (1)
WHAT: Hyperparathyroidism. Hyperparathyroidism: a condition due to an increase in the secretion of the parathyroids, causing generalized osteitis fibrosa cystica, elevated serum calcium, decreased serum phosphorus, and increased excretion of both calcium and phosphorus. WHY: Several rheumatological disorders are associated with hyperpara- thyroidism. First, hyperuricemia and gouty arthritis (which may mimic hyperparathyroidism with renal stone formation and colic) have an increased incidence in patients with hyperparathyroidism. Second, patients with primary hyperparathyroidism show an increased incidence of chondrocalcinosis with episodes of calcium pyrophosphate crystal induced synovitis. Approximately 25% of patients with hyperparathyroidism will show radiographic evidence of calcification of articular cartilage and joint capsules. Finally, there can be a synovial and cartilaginous lesion ("osteogenic synovitis") in patients with hyperparathyroidism which may mimic other primary rheumatic diseases such as rheumatoid arthritis. In osteogenic synovitis there is softening and collapse of subchondral bone. Eventually the cartilage overlying this area erodes and is replaced by an irregular fibrocartilage. Eventually the articular surface of the joint is destroyed and secondary degenerative arthritis may develop. REFS: 1) Zvaifler, NJ; Reefe, WE and Black, RL: Articular manifestations in primary hyperparathyroidism. Arthritis Rheum 5:237, 1962. 2) Scott, JT; Dixon, ASJ and Bywaters, EGL: Association of hyperuricemia and gout with hyperparathyroidism. Br Med J 1:1070, 1964. 3) Bywaters, EGL and Scott, JT : Joint lesions of hyperparathyroidism. Ann Rheum Dis 22:171-87, 1963.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Parathyroid Diseases C0030517
Children (2)
img Hyperparathyroidism, Primary C0221002
img Hyperparathyroidism, Secondary C0020503
Ancestral Roots
RootRoot Plus OneDepthParent
img Endocrine System Diseases C0014130img Parathyroid Diseases C00305173img Parathyroid Diseases C0030517
Relationships (80)

Relation Types:
diso_​to_​anat : 7
diso_​to_​chem : 41
diso_​to_​diso : 29
diso_​to_​phen : 2
diso_​to_​phys : 1


Relationships:
none : 40
classifies : 1
clinically_​similar : 1
expanded_​form_​of : 1
is_​associated_​anatomic_​site_​of : 3
isa : 6
mapped_​to : 1
may_​treat : 27
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO277img Complication Aspects C1171258
DISO_to_DISO218img NEOPL PARATHYROID C0030521
DISO_to_ANAT185img In Blood C0005768
DISO_to_DISO162img Adenoma C0001430
DISO_to_DISO148img Complication Aspects C1171258
DISO_to_CHEM137img Parathyroid Hormone C0030520
DISO_to_ANAT109img Parathyroid Glands C0030518
DISO_to_ANAT83img In Blood C0005768
DISO_to_CHEM82img Technetium Tc 99m Sestamibi C0162680
DISO_to_PHEN82img genetic aspects C0017399
DISO_to_CHEM74img Calcium C0006675
DISO_to_DISO69img Hypercalcemia C0020437
DISO_to_CHEM68img Parathyroid Hormone C0030520
DISO_to_DISO68img NEOPL PARATHYROID C0030521
DISO_to_PHEN46img genetic aspects C0017399
DISO_to_ANAT44img Parathyroid Glands C0030518
DISO_to_CHEM41img Naphthalenes C0027378
DISO_to_DISO39img Adenoma C0001430
DISO_to_CHEM37img Radiopharmaceuticals C0182638
DISO_to_DISO36img Kidney Failure, Chronic C0022661
DISO_to_DISO31img CALCIUM BLOOD INCREASED C0020437
DISO_to_DISO26img Kidney Failure, Chronic C0022661
DISO_to_CHEM24img Technetium Tc 99m Sestamibi C0162680
DISO_to_PHYS24img Bone Density C0005938
DISO_to_DISO23img Jaw Neoplasms C0022364
Genes (15)

Species:
human : 15
SpeciesGeneGeneIdGene NameEvidence
HumanCDC7379577cell division cycle 73
img GAD, Score=1000, Pubmed Id: 14985373, UMLKSK CUI: C0020502
img OMIM, Score=1000, UMLKSK CUI: C0020502
HumanKL9365klotho
INFERRED, Score=800, UMLKSK CUI: C0020502
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
img GENERIF, Score=1000, Pubmed Id: 16213262, UMLKSK CUI: C0020502
img GENERIF, Score=1000, Pubmed Id: 12656660, UMLKSK CUI: C0020502
img GENERIF, Score=1000, Pubmed Id: 16738533, UMLKSK CUI: C0020502
HumanRET5979ret proto-oncogene
img OMIM, Score=1000, UMLKSK CUI: C0020502
HumanPTH5741parathyroid hormone
img GAD, Score=1000, Pubmed Id: 12046039, UMLKSK CUI: C0020502
HumanOCRL4952oculocerebrorenal syndrome of Lowe
INFERRED, Score=800, UMLKSK CUI: C0020502
HumanMEN14221multiple endocrine neoplasia I
img GAD, Score=1000, Pubmed Id: 12324758, UMLKSK CUI: C0020502
img GAD, Score=1000, Pubmed Id: 14985373, UMLKSK CUI: C0020502
img GAD, Score=1000, Pubmed Id: 15754732, UMLKSK CUI: C0020502
img GENERIF, Score=861, Pubmed Id: 15635078, UMLKSK CUI: C0020502
HumanKCNQ13784potassium voltage-gated channel, KQT-like subfamily, member 1
INFERRED, Score=800, UMLKSK CUI: C0020502
HumanIL6R3570interleukin 6 receptor
img GENERIF, Score=861, Pubmed Id: 12414855, UMLKSK CUI: C0020502
HumanGNAS2778GNAS complex locus
img OMIM, Score=1000, UMLKSK CUI: C0020502
HumanCYP27B11594cytochrome P450, family 27, subfamily B, polypeptide 1
INFERRED, Score=800, UMLKSK CUI: C0020502
HumanCASR846calcium-sensing receptor
img GAD, Score=1000, Pubmed Id: 12150336, UMLKSK CUI: C0020502
img GENERIF, Score=1000, Pubmed Id: 12656660, UMLKSK CUI: C0020502
img GAD, Score=1000, Pubmed Id: 11589681, UMLKSK CUI: C0020502
img GAD, Score=1000, Pubmed Id: 14985373, UMLKSK CUI: C0020502
img GENERIF, Score=1000, Pubmed Id: 16738533, UMLKSK CUI: C0020502
HumanCCND1595cyclin D1
img GENERIF, Score=861, Pubmed Id: 18398822, UMLKSK CUI: C0020502
HumanADM133adrenomedullin
INFERRED, Score=800, UMLKSK CUI: C0020502
HumanACP554acid phosphatase 5, tartrate resistant
INFERRED, Score=800, UMLKSK CUI: C0020502
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020502Hyperparathyroidism0self