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Genes (23)
Species: human : 23 | |
Human | APOA5 | 116519 | apolipoprotein A-V | In the Dutch Familial combined hyperlipidemia [FCH] families studied variants in the APOA5 gene are associated with FCH and an atherogenic lipid profile | Human | TXNIP | 10628 | thioredoxin interacting protein | TXNIP gene does not ply a major role in familial combined hyperlipidemia, or related traits | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | A clear sexual dimorphism of total adiponectin and its multimers in patients with familial combined hyperlipidemia was observed adiponectin has a role in adipose tissue metabolism and in the pathophysiology of familial combined hyperlipidemia | Human | LZTR1 | 8216 | leucine-zipper-like transcription regulator 1 | TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia | Human | USF1 | 7391 | upstream transcription factor 1 | familial combined hyperlipidemia was linked and associated with the USF1 gene in 60 extended Finnish families We replicated the association between USF1 and traits related to familial combined hyperlipidemia upstream transcription factor 1 has a part in the etiology of familial combined hyperlipidemia and its component traits, although the mechanism of causality still remains largely unknown role of USF1 in familial combined hyperlipidemia in an outbred population links the 16q24.1 region to an FCHL-component trait in Mexicans Upstream transcription factor 1 (USF1), is the first gene associated with familial combined hyperlipidemia | Human | SCD | 6319 | stearoyl-CoA desaturase (delta-9-desaturase) | Fatty acid desaturation index (a marker of SCD1 activity) is a highly heritable trait that is associated with the dyslipidemia observed in familial combined hyperlipidemia | Human | RXRG | 6258 | retinoid X receptor, gamma | RXRgamma contributes to the genetic background of familial combined hyperlipidemia | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | genes of C3, HSL, and PPARgamma may exert a modifying effect on lipid and glucose metabolism in familial combined hyperlipidemia PPARgamma is a quantitative trait locus for free fatty acid and glycerol, against a background of insulin resistance for adipose tissue lipid metabolism, and therefore as a modifier gene in familial combined hyperlipidemia | Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | PPARA gene is a modifier of the familial combined hyperlipidemia phenotype | Human | PON1 | 5444 | paraoxonase 1 | PON1 is biochemically and genetically associated with familial combined hyperlipidemia | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E | Human | LPL | 4023 | lipoprotein lipase | variations in genes affecting the removal rate of triglycerides (TG) from plasma significantly influence the lipid phenotypic expression of familial combined hyperlipidemia Title:|Association:Not Found|Conclusion:Not Found | Human | IRS1 | 3667 | insulin receptor substrate 1 | genetic variants in the gene appear not to have a major role as modifier genes in familial combined hyperlipidemia | Human | FN1 | 2335 | fibronectin 1 | familial combined hyperlipidemia plasma stimulated secretion of several distinct hepatic proteins, among which fibronectin was identified | Human | FABP2 | 2169 | fatty acid binding protein 2, intestinal | genetic variants in the gene appear not to have a major role as modifier genes in familial combined hyperlipidemia | Human | CD36 | 948 | CD36 molecule (thrombospondin receptor) | CD36/FAT overexpression in familial combined hyperlipidemia occurs very early in adipocyte differentiation and may be of genetic origin | Human | C3 | 718 | complement component 3 | genes of C3, hormone-sensitive lipase, and PPARgamma may exert a modifying effect on lipid and glucose metabolism in familial combined hyperlipidemia The postprandial plasma C3 response is impaired in familial combined hyperlipidemia patients, probably as a result of a delayed response by C3 (the precursor for the biologically active acylation-stimulating protein) acting on free fatty acid metabolism | Human | APOE | 348 | apolipoprotein E | The apoE2 allele was negatively associated with hypertriglyceridemia/hyperapobetalipoproteinemia in the absence of a deleterious LPL gene variant ApoE polymorphism appears to be associated with variance of the lipoprotein phenotype in Chinese families with familial combined hyperlipidemia PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E Title:Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms.|Association:Not Found|Conclusion:Not Found | Human | APOB | 338 | apolipoprotein B | Patients with familial combined hyperlipidemia have increased carotid intimamedia thickness, strongly related to the apoB/apoA-I ratio (apolipoprotein B/apolipoprotein A-I) | Human | APOA2 | 336 | apolipoprotein A-II | Genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia | Human | APOA1 | 335 | apolipoprotein A-I | Patients with familial combined hyperlipidemia have increased carotid intimamedia thickness, strongly related to the apoB/apoA-I ratio (apolipoprotein B/apolipoprotein A-I) | Human | ADRB3 | 155 | adrenoceptor beta 3 | genetic variants in the gene appear not to have a major role as modifier genes in familial combined hyperlipidemia | Human | ADD1 | 118 | adducin 1 (alpha) | Title:Association between the alpha-adducin Gly460Trp polymorphism and systolic blood pressure in familial combined hyperlipidemia.|Association:Y|Conclusion:This study shows that the 460Trp allele is associated with FCHL. Furthermore, SBP is increased in patients carrying the 460Trp allele. |
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