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Details
Link-It Detail - Disease - Hypercholesterolemia
Debug Stats
  • ### Total Build Time: 305 ms 64.278 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 205 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 551 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.515 KB
  • CONCEPT_RELATIONSHIPS gt=256 ms Completed: 256 ms rowSize= 13.685 KB
  • CONCEPT_GENES gt=35 ms Completed: 35 ms rowSize= 46.638 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Hypercholesterolemia C0020443
Definition (1)
abnormally high levels of cholesterol in the blood.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Hyperlipidemias C0020473
Ancestral Roots
RootRoot Plus OneDepthParent
img Nutritional and Metabolic Diseases C0028715img Metabolic Diseases C00255176img Hyperlipidemias C0020473
Relationships (233)

Relation Types:
diso_​to_​anat : 11
diso_​to_​chem : 168
diso_​to_​diso : 44
diso_​to_​gene : 1
diso_​to_​phen : 2
diso_​to_​phys : 7


Relationships:
none : 129
isa : 3
mapped_​to : 6
may_​treat : 95
Page Size
Current 25
  Page 1 of 10
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANAT831img In Blood C0005768
DISO_to_ANAT819img In Blood C0005768
DISO_to_CHEM639img Agents, Anticholesteremic C0003277
DISO_to_DISO554img Complication Aspects C1171258
DISO_to_DISO551img Complication Aspects C1171258
DISO_to_CHEM505img Hydroxymethylglutaryl-CoA Reductase Inhibitors C0360714
DISO_to_CHEM493img Hydroxymethylglutaryl-CoA Reductase Inhibitors C0360714
DISO_to_CHEM487img Agents, Anticholesteremic C0003277
DISO_to_CHEM283img Cholesterol C0008377
DISO_to_CHEM260img Cholesterol, LDL C0023824
DISO_to_PHEN256img genetic aspects C0017399
DISO_to_CHEM243img Cholesterol C0008377
DISO_to_DISO192img Cardiovascular Diseases C0007222
DISO_to_CHEM186img SIMVASTATIN C0074554
DISO_to_DISO180img Atherosclerosis C0004153
DISO_to_CHEM168img Acids, Heptanoic C0019227
DISO_to_CHEM168img Pyrroles C0034325
DISO_to_CHEM163img Acids, Heptanoic C0019227
DISO_to_PHEN162img genetic aspects C0017399
DISO_to_CHEM161img Pyrroles C0034325
DISO_to_CHEM150img Azetidines C0004490
DISO_to_DISO148img Hypertension C0020538
DISO_to_DISO147img Hypertension C0020538
DISO_to_CHEM143img SIMVASTATIN C0074554
DISO_to_DISO141img Coronary Disease C0010068
Genes (47)

Species:
human : 47
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanPCSK9255738proprotein convertase subtilisin/kexin type 9
img GAD, Score=1000, Pubmed Id: 15099351, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 16159606, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 17435765, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 17101087, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 18799458, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 16211558, UMLKSK CUI: C0020443
img GENERIF, Score=812, Pubmed Id: 15772090, UMLKSK CUI: C0020443
HumanABCG864241ATP-binding cassette, sub-family G (WHITE), member 8
img GENERIF, Score=1000, Pubmed Id: 19012522, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 18581044, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 18522623, UMLKSK CUI: C0020443
img OMIM, Score=1000, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 14703505, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 14703505, UMLKSK CUI: C0020443
HumanABCG564240ATP-binding cassette, sub-family G (WHITE), member 5
img GENERIF, Score=1000, Pubmed Id: 14703505, UMLKSK CUI: C0020443
img OMIM, Score=1000, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 14703505, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 18522623, UMLKSK CUI: C0020443
HumanAPOB48R55911
img GENERIF, Score=1000, Pubmed Id: 15830122, UMLKSK CUI: C0020443
HumanAPTX54840aprataxin
img OMIM, Score=1000, UMLKSK CUI: C0020443
HumanNPC1L129881NPC1-like 1
img GENERIF, Score=827, Pubmed Id: 15671032, UMLKSK CUI: C0020443
HumanLDLRAP126119low density lipoprotein receptor adaptor protein 1
img GENERIF, Score=861, Pubmed Id: 16870701, UMLKSK CUI: C0020443
HumanC7orf1610842
img OMIM, Score=1000, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 12955585, UMLKSK CUI: C0020443
HumanSREBF26721sterol regulatory element binding transcription factor 2
img GAD, Score=1000, Pubmed Id: 16158080, UMLKSK CUI: C0020443
HumanSREBF16720sterol regulatory element binding transcription factor 1
img GAD, Score=1000, Pubmed Id: 16158080, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 16005884, UMLKSK CUI: C0020443
HumanSOD16647superoxide dismutase 1, soluble
img GENERIF, Score=861, Pubmed Id: 15473258, UMLKSK CUI: C0020443
HumanSELP6403selectin P (granule membrane protein 140kDa, antigen CD62)
img GENERIF, Score=1000, Pubmed Id: 12036879, UMLKSK CUI: C0020443
HumanSELE6401selectin E
img GENERIF, Score=1000, Pubmed Id: 16843446, UMLKSK CUI: C0020443
img GENERIF, Score=1000, Pubmed Id: 18649056, UMLKSK CUI: C0020443
HumanPON15444paraoxonase 1
img GAD, Score=1000, Pubmed Id: 16030523, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 15969877, UMLKSK CUI: C0020443
HumanABCB15243ATP-binding cassette, sub-family B (MDR/TAP), member 1
img GAD, Score=1000, Pubmed Id: 16002074, UMLKSK CUI: C0020443
img GENERIF, Score=708, Pubmed Id: 15033457, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 15081455, UMLKSK CUI: C0020443
HumanSERPINE15054serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
img GENERIF, Score=694, Pubmed Id: 16123492, UMLKSK CUI: C0020443
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
img GENERIF, Score=1000, Pubmed Id: 17243909, UMLKSK CUI: C0020443
HumanTRNI4565tRNA
img GENERIF, Score=694, Pubmed Id: 15498972, UMLKSK CUI: C0020443
HumanLPL4023lipoprotein lipase
img GAD, Score=1000, Pubmed Id: 16030523, UMLKSK CUI: C0020443
img OMIM, Score=1000, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 15135251, UMLKSK CUI: C0020443
HumanLIPC3990lipase, hepatic
img GAD, Score=1000, Pubmed Id: 15135251, UMLKSK CUI: C0020443
img GENERIF, Score=893, Pubmed Id: 18364377, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 16030523, UMLKSK CUI: C0020443
HumanLEPR3953leptin receptor
img GENERIF, Score=1000, Pubmed Id: 14625131, UMLKSK CUI: C0020443
HumanLDLR3949low density lipoprotein receptor
Click here to display 17 evidence detail records.
HumanITIH43700inter-alpha-trypsin inhibitor heavy chain family, member 4
img OMIM, Score=1000, UMLKSK CUI: C0020443
img GAD, Score=1000, Pubmed Id: 14661079, UMLKSK CUI: C0020443
HumanHMOX13162heme oxygenase (decycling) 1
img GENERIF, Score=1000, Pubmed Id: 12377749, UMLKSK CUI: C0020443
HumanHMGCR31563-hydroxy-3-methylglutaryl-CoA reductase
img GENERIF, Score=1000, Pubmed Id: 17870053, UMLKSK CUI: C0020443
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0020443Hypercholesterolemia0self