Debug Stats | ### Total Build Time: 35 ms 43.582 KB CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 371 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 309 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 232 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 556 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.530 KBCONCEPT_RELATIONSHIPS gt=12 ms Completed: 12 ms rowSize= 12.753 KBCONCEPT_GENES gt=16 ms Completed: 16 ms rowSize= 26.688 KBCONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.142 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
|
Genes (44)
Species: human : 44 | |
Human | NDUFS7 | 374291 | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | Lesions in basal ganglia, brainstem, cerebellum, thalamus, spinal cord characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | C8orf38 | 137682 | | Lesions in basal ganglia, brainstem, cerebellum, thalamus, spinal cord characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | Gliosis in the substantia nigra | Human | L2HGDH | 79944 | L-2-hydroxyglutarate dehydrogenase | Neuropathologic examination shows extensive spongiosis and gliosis | Human | SLC17A7 | 57030 | solute carrier family 17 (vesicular glutamate transporter), member 7 | Alterations in the pattern of vesicular glutamate transporter 1-immunoreactivity that perfectly matched the neuronal loss and gliosis, as well as the decrease in the number of asymmetrical synapses identified by electron microscopy in this tissue | Human | TREM2 | 54209 | triggering receptor expressed on myeloid cells 2 | | Human | LRPPRC | 10128 | leucine-rich pentatricopeptide repeat containing | Lesions characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | SCO2 | 9997 | SCO2 cytochrome c oxidase assembly protein | Gliosis, necrosis, neuronal loss in basal ganglia, brainstem, and spinal cord | Human | EIF2B5 | 8893 | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | Biopsy shows white matter hypomyelination, demyelination, gliosis | Human | EIF2B2 | 8892 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | Biopsy shows white matter hypomyelination, demyelination, gliosis | Human | EIF2B3 | 8891 | eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa | Biopsy shows white matter hypomyelination, demyelination, gliosis | Human | EIF2B4 | 8890 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | Biopsy shows white matter hypomyelination, demyelination, gliosis | Human | PLA2G6 | 8398 | phospholipase A2, group VI (cytosolic, calcium-independent) | | Human | TYROBP | 7305 | TYRO protein tyrosine kinase binding protein | | Human | TBP | 6908 | TATA box binding protein | Gliosis in the striatum, medial thalamic nuclei, and inferior olives | Human | SURF1 | 6834 | surfeit 1 | Lesions in basal ganglia, brainstem, cerebellum, thalamus, spinal cord characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | SDHA | 6389 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | Lesions in basal ganglia, brainstem, cerebellum, thalamus, spinal cord characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | Results suggest that MCP-1/CCL2 and IP-10/CXCL10 produced by astrocytes may activate astrocytes in an autocrine or paracrine manner and direct reactive gliosis followed by migration and activation of microglia/macrophages in demyelinating lesions | Human | SCN1B | 6324 | sodium channel, voltage-gated, type I, beta subunit | the expression of NaCh beta1 subunit protein in astrocytes is plastic, and indicate a novel mechanism for modulation of glial function in gliosis-associated pathologies | Human | S100B | 6285 | S100 calcium binding protein B | S100B has a role in exacerbating brain damage and periinfarct reactive gliosis (astrocytosis and microgliosis) during the subacute phase of middle cerebral artery occlusion | Human | PRNP | 5621 | prion protein | Cell loss and gliosis in the basal ganglia this case demonstrates that multisequences of magnetic resonance can detect prion-induced gliosis in vivo, as confirmed by a neuropathologic examination performed only a few days after radiological examination | Human | POLG | 5428 | polymerase (DNA directed), gamma | | Human | SERPINI1 | 5274 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | | Human | PDHA1 | 5160 | pyruvate dehydrogenase (lipoamide) alpha 1 | Lesions characterized by demyelination, necrosis, gliosis, spongiosis, and capillary proliferation | Human | PARK2 | 5071 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | Neuronal loss and gliosis in the substantia nigra pars compacta |
|