Mouse | SULF2 | 55959 | sulfatase 2 | Array and quantitative real-time PCR analysis demonstrated elevated expression similar to Pdgfralpha of retrovirally tagged genes Abhd2, Ddr1, Fos, Ng2, Ppfibp1, Rad51b and Sulf2 in both glioma types compared to neonatal and adult normal brain. |
Mouse | DLL1 | 28514 | delta-like 1 (Drosophila) | In addition, pretreatment of glioma cells with Notch-1 or Delta-like-1 small interfering RNA significantly prolongs survival in a murine orthotopic brain tumor model. |
Mouse | ABHD2 | 11057 | abhydrolase domain containing 2 | Array and quantitative real-time PCR analysis demonstrated elevated expression similar to Pdgfralpha of retrovirally tagged genes Abhd2, Ddr1, Fos, Ng2, Ppfibp1, Rad51b and Sulf2 in both glioma types compared to neonatal and adult normal brain. |
Mouse | NES | 10763 | nestin | The resulting tumors were nestin positive and resembled a spectrum of glioma morphologies ranging in astrocytic character depending on cell-of-origin and presence of activated Akt. |
Mouse | HYOU1 | 10525 | hypoxia up-regulated 1 | Tumors raised after inoculation of immunocompromised mice with ORP150 antisense C6 glioma transfectants demonstrated an initial phase of growth comparable to wild-type C6 glioma cells which was followed by marked regression within 8 days. |
Mouse | OLIG2 | 10215 | oligodendrocyte lineage transcription factor 2 | Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically relevant murine model. |
Mouse | PLAA | 9373 | phospholipase A2-activating protein | Significant tumor regression was observed 72 hours following a single treatment with PLAP in an animal air pouch model of glioma. |
Mouse | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | Several human glioma cell lines were found to overexpress hyaluronan synthases, but they did so in conjunction with hyaluronidase Hyal2 and MGEA5 expression. |
Mouse | EZR | 7430 | ezrin | Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2. |
Mouse | THBS2 | 7058 | thrombospondin 2 | Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model. Thus, the antiangiogenic activity of TSP-2 is capable of inhibiting the growth of gliomas in part by reducing the levels of MMP-2 in the tumor microvasculature. |
Mouse | SOD1 | 6647 | superoxide dismutase 1, soluble | Neither C6 glioma cells nor cortical astrocytes expressing mutant SOD1 were more susceptible to any of the free radical generating systems compared to control cells. |
Mouse | SFRP2 | 6423 | secreted frizzled-related protein 2 | sFRP-2 strongly promotes the growth of intracranial glioma xenografts in nude mice. |
Mouse | RAD51 | 5888 | RAD51 recombinase | When the glioma cells were implanted in the cisterna magna of mice followed by treatment with RAD51 antisense ODNs, the survival time of the mice was markedly prolonged compared to that of the untreated group (p < 0.001, logrank test). Treatment of mouse 203G glioma cells with 100 nM of RAD51 antisense ODNs significantly enhanced the radiation-induced cell kill compared to control cells, and cells treated with sense or scrambled ODNs. |
Mouse | OSM | 5008 | oncostatin M | Complete inhibition of in vivo glioma growth by oncostatin M. We describe here the oncostatin M (OSM)-dependent inhibition of in vivo tumour formation after intracerebral inoculation of glioblastoma cells in mice. |
Mouse | NDN | 4692 | necdin, melanoma antigen (MAGE) family member | Among various established cell lines including neuroblastoma and glioma cells, only differentiated embryonal carcinoma cells (P19 and F9) expressed necdin mRNA. |
Mouse | MARCKS | 4082 | myristoylated alanine-rich protein kinase C substrate | The regulation and expression of protein kinase C (PKC) and phosphomyristin C (PMC) (a principal substrate of PKC which is the major myristylated protein in lymphocyte and glioma lines that express it) in murine B and T lymphocytes were investigated. |
Mouse | INSR | 3643 | insulin receptor | The PILs were targeted to U87 human glioma cells with the 83-14 murine monoclonal antibody (MAb) to the human insulin receptor (HIR). |
Mouse | IL13 | 3596 | interleukin 13 | Click here to display 3 evidence detail records. |
Mouse | HAS2 | 3037 | hyaluronan synthase 2 | Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity. |
Mouse | GRLF1 | 2909 | glucocorticoid receptor DNA binding factor 1 | p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. |
Mouse | GRIN1 | 2902 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | In the present study, we provide immunochemical evidence for the expression of both the NMDAR1 and NMDAR2A/B receptor subunits in PC12W cells, that express only the angiotensin type-2 (AT2) receptor subtype, and in NG108-15 (NG108) cells, a murine neuroblastoma x glioma hybrid that expresses both the angiotensin type-1 (AT1) and AT2 receptor subtypes. |
Mouse | GAS1 | 2619 | growth arrest-specific 1 | Furthermore, retroviral-mediated transfer of gas1 to gliomas implanted in nude mice induces a significant inhibition of tumor growth, accompanied by increased caspase-3 activation. |
Mouse | CDH5 | 1003 | cadherin 5, type 2 (vascular endothelium) | CONCLUSIONS: Inhibition of angiogenesis achieved by blocking either VEGFR-2 or VE-cadherin can cause increased glioma cell invasion in an orthotopic model. The anti-VE-cadherin monoclonal antibody E4G10 was a weaker inhibitor of tumor angiogenesis and growth than DC101, and also caused a weaker increase in tumor cell invasion.CONCLUSIONS: Inhibition of angiogenesis achieved by blocking either VEGFR-2 or VE-cadherin can cause increased glioma cell invasion in an orthotopic model. |
Mouse | CALR | 811 | calreticulin | Although calreticulin (Crt) is primarily localized to the endoplasmic reticulum (ER), our results using biotinylation and immunocytochemical methods indicate that a small but significant amount of Crt is present and forms large patches on the surface of NG108-15 cells (a mouse neuroblastoma-rat glioma hybrid cell line). |
Mouse | AXL | 558 | AXL receptor tyrosine kinase | Inhibition of Axl signaling by overexpression of a dominant-negative receptor mutant (AXL-DN) suppressed experimental gliomagenesis (growth inhibition >85%, P _lt_ 0.05) and resulted in long-term survival of mice after intracerebral glioma cell implantation when compared with Axl wild-type (AXL-WT) transfected tumor cells (survival times: AXL-WT, 10 days; AXL-DN, >72 days). |