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Details
Link-It Detail - Disease - Gastroesophageal Reflux
Debug Stats
  • ### Total Build Time: 117 ms 37.331 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 344 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.351 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 565 bytes
  • CONCEPT_CHILDREN gt=2 ms Completed: 2 ms rowSize= 562 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 4.102 KB
  • CONCEPT_RELATIONSHIPS gt=104 ms Completed: 104 ms rowSize= 15.066 KB
  • CONCEPT_GENES gt=7 ms Completed: 7 ms rowSize= 14.008 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.157 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Gastroesophageal Reflux C0017168
Definition (1)

Your esophagus is the tube that carries food from your mouth to your stomach. Gastroesophageal reflux disease (GERD) happens when a muscle at the end of your esophagus does not close properly. This allows stomach contents to leak back, or reflux, into the esophagus and irritate it.

You may feel a burning in the chest or throat called heartburn. Sometimes, you can taste stomach fluid in the back of the mouth. This is acid indigestion. If you have these symptoms more than twice a week, you may have GERD.

Anyone, including infants and children, can have GERD. If not treated, it can lead to more serious health problems. In some cases, you might need medicines or surgery. However, many people can improve their symptoms by

  • Avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn
  • Eating smaller meals
  • Not eating close to bedtime
  • Losing weight if needed
  • Wearing loose-fitting clothes

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Esophageal Motility Disorders C0014858
Children (1)
img Laryngopharyngeal Reflux C1168250
Ancestral Roots
RootRoot Plus OneDepthParent
img Digestive System Diseases C0012242img Gastrointestinal Diseases C00171786img Esophageal Motility Disorders C0014858
img Stomatognathic Diseases C0038368img Pharyngeal Diseases C00313455img Esophageal Motility Disorders C0014858
img Otorhinolaryngologic Diseases C0029896img Pharyngeal Diseases C00313455img Esophageal Motility Disorders C0014858
Relationships (306)

Relation Types:
diso_​to_​anat : 19
diso_​to_​chem : 202
diso_​to_​diso : 78
diso_​to_​phen : 2
diso_​to_​phys : 5


Relationships:
none : 100
associated_​with : 2
classifies : 2
is_​associated_​anatomic_​site_​of : 2
is_​associated_​disease_​of : 1
isa : 4
mapped_​to : 5
may_​be_​finding_​of_​disease : 1
may_​treat : 183
related_​to : 6
Page Size
Current 25
  Page 1 of 13
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO986img Complication Aspects C1171258
DISO_to_DISO978img Complication Aspects C1171258
DISO_to_CHEM392img Proton Pump Inhibitors C0358591
DISO_to_CHEM288img Proton Pump C0018440
DISO_to_CHEM273img Anti-Ulcer Agent C0003216
DISO_to_ANAT266img Esophagus C0014876
DISO_to_CHEM266img 1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)- C0028978
DISO_to_ANAT227img Esophagus C0014876
DISO_to_DISO173img Barrett Esophagus C0004763
DISO_to_DISO169img Helicobacter Infections C0079487
DISO_to_DISO168img Barrett Esophagus C0004763
DISO_to_CHEM164img 2 Pyridinylmethylsulfinylbenzimidazoles C1721069
DISO_to_CHEM163img Anti-Ulcer Agent C0003216
DISO_to_CHEM138img 1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)- C0028978
DISO_to_DISO126img Esophagitis, Peptic C0014869
DISO_to_ANAT125img Esophagogastric Junction C0014871
DISO_to_DISO119img Heartburn C0018834
DISO_to_DISO116img Esophagitis, Peptic C0014869
DISO_to_DISO110img Asthma C0004096
DISO_to_DISO106img Asthma C0004096
DISO_to_ANAT103img Acid, Gastric C0017119
DISO_to_DISO103img Esophagitis C0014868
DISO_to_DISO101img Esophageal Neoplasms C0014859
DISO_to_CHEM99img Enzyme Inhibitors C0014432
DISO_to_DISO99img Hiatal Hernia C3489393
Genes (16)

Species:
human : 16
SpeciesGeneGeneIdGene NameEvidence
HumanWNK165125WNK lysine deficient protein kinase 1
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanNIPBL25836Nipped-B homolog (Drosophila)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanIKBKAP8518inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanWHSC17468Wolf-Hirschhorn syndrome candidate 1
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanTSPYL17259TSPY-like 1
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanCDKL56792cyclin-dependent kinase-like 5
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanSALL16299sal-like 1 (Drosophila)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanMAP2K25605mitogen-activated protein kinase kinase 2
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanMAPK105602mitogen-activated protein kinase 10
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanNPHS14868nephrosis 1, congenital, Finnish type (nephrin)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanMID14281midline 1 (Opitz/BBB syndrome)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanMECP24204methyl CpG binding protein 2 (Rett syndrome)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanFBN12200fibrillin 1
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanDDC1644dopa decarboxylase (aromatic L-amino acid decarboxylase)
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanBRAF673v-raf murine sarcoma viral oncogene homolog B
img OMIM, Score=1000, UMLKSK CUI: C0017168
HumanATRX546alpha thalassemia/mental retardation syndrome X-linked
img OMIM, Score=1000, UMLKSK CUI: C0017168
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0017168Gastroesophageal Reflux0self