Human | PDB4 | 94003 | Paget disease of bone 4 | Fractures of vertebral bodies Fractures of the long bones |
Human | GNPTAB | 79158 | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | WNK1 | 65125 | WNK lysine deficient protein kinase 1 | Painless fractures due to injury |
Human | ANKH | 56172 | ANKH inorganic pyrophosphate transport regulator | ANKH may be a candidate gene affecting bone size and geometry variation, and thus may be relevant for osteoporosis fracture risk |
Human | CRTAC1 | 55118 | cartilage acidic protein 1 | in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III |
Human | TREM2 | 54209 | triggering receptor expressed on myeloid cells 2 | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | OSTM1 | 28962 | osteopetrosis associated transmembrane protein 1 | |
Human | GREM1 | 26585 | gremlin 1, DAN family BMP antagonist | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | CELA3B | 23436 | chymotrypsin-like elastase family, member 3B | Reduced fecal elastase 1 connected with lowered serum levels of vitamin D3 is associated with osteoporotic bone fractures |
Human | CRTAP | 10491 | cartilage associated protein | Fracture frequency decreased post puberty |
Human | TCIRG1 | 10312 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Although adiponectin was a negative determinant of BMD in two independent cohorts, it was not associated with fracture risk in men |
Human | SLC9A3R1 | 9368 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | Increased susceptibility to fractures |
Human | SLC7A7 | 9056 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | |
Human | SQSTM1 | 8878 | sequestosome 1 | Fractures of the long bones Fractures of vertebral bodies |
Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Fractures of vertebral bodies Fractures of the long bones |
Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | We have discovered common sequence variants that are consistently associated with bone mineral density and with low-trauma fractures in three populations of European descent |
Human | SEMA7A | 8482 | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | PRDM2 | 7799 | PR domain containing 2, with ZNF domain | observed no association of the RIZ1 Pro704 insertion-deletion polymorphism with BMD or fracture risk |
Human | WNT7A | 7476 | wingless-type MMTV integration site family, member 7A | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | A Cdx-2 binding site polymorphism (G to A) in the promoter region of the vitamin D receptor gene was reported. investigated the relationship between the VDR Cdx-2 genotype and risk of fracture VDR genotypes are associated with the risk of fracture in postmenopausal women independently of bone mineral density the common and potentially functional VDR translation start site polymorphism confers a modestly increased relative risk of fracture among older white women Associations were observed between the occurrence of fractures and the baT haplotypes of the VDR gene |
Human | UROS | 7390 | uroporphyrinogen III synthase | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | TYROBP | 7305 | TYRO protein tyrosine kinase binding protein | INFERRED, Score=800, UMLKSK CUI: C0016658 |
Human | TRPS1 | 7227 | trichorhinophalangeal syndrome I | Predisposition to fracture |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | An association between T29 -C polymorphisms of TGF-beta1 gene and BMD, bone turnover and fragility fractures were demonstrated in postmenopausal southern Chinese women |