Human | CAQ14 | 171512 | Circulating adiponectin QTL on chromosome 14 | Low plasma levels predict the presence of liver steatosis in obese subjects |
Human | ADIPOR2 | 79602 | adiponectin receptor 2 | In patients with chronic hepatitis c, adiponectin and receptors(AdipoR1 and AdipoR2)play a role in hepatic inflammation in both sexes and liver steatosis in males |
Human | ABHD5 | 51099 | abhydrolase domain containing 5 | |
Human | ADIPOR1 | 51094 | adiponectin receptor 1 | the -8503 G/A single-nucleotide polymorphism in the promoter or the -1927 T/C single-nucleotide polymorphism in intron 1 of ADIPOR1 may affect insulin sensitivity and liver fat in humans |
Human | BSCL2 | 26580 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | |
Human | AGPAT2 | 10555 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | In summary, the presented data support the idea that adiponectin might be of critical relevance for cytokine regulation in obesity and fatty liver diseases affecting primarily macrophage functions a high serum concentration of adiponectin is associated with a protective effect against hepatic steatosis |
Human | ALMS1 | 7840 | Alstrom syndrome 1 | |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Data show no difference between serum concentrations of transforming growth factor-beta1 and ferritin in fatty liver and non-alcoholic steatohepatitis, suggesting that these forms share more common aspects than previously thought |
Human | SREBF1 | 6720 | sterol regulatory element binding transcription factor 1 | SREBP-1c may not play a prominent role in the pathogenesis of hepatitic C-related steatosis SREBP-1c could participate to the hepatic steatosis observed in humans and related to alcohol consumption and hyperhomocysteinaemia, two pathologies which are concomitant with a stress of the endoplasmic reticulum and an insulin activation |
Human | PPP1R3A | 5506 | protein phosphatase 1, regulatory subunit 3A | |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E |
Human | MTTP | 4547 | microsomal triglyceride transfer protein | In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infected with hepatitis C virus genotype 3 to develop higher degree of fatty liver accumulation |
Human | MET | 4233 | met proto-oncogene | Fas antagonism by Met is abrogated in human fatty liver disease |
Human | LMNA | 4000 | lamin A/C | |
Human | LEP | 3952 | leptin | Recombinant human leptin leads to significant and sustained improvements in glycemia, dyslipidemia, serum leptic levels, hepatic steatosis and represents the first novel, effective, long-term treatment for severe forms of lipodystrophy |
Human | IL13RA2 | 3598 | interleukin 13 receptor, alpha 2 | Hepatic stellate cells in sinusoidal lesions of liver from patients with nonalcoholic steatohepatitis express high levels of high-affinity IL-13R (IL-13 receptor alpha2), whereas fatty liver and normal liver specimens do not express IL-13Ralpha2 |
Human | IL10 | 3586 | interleukin 10 | in an animal model of diet-induced fatty liver disease, the inhibition of IL-10 promotes the increased expression of inflammatory cytokines, the worsening of insulin signaling and the activation of gluconeogenic and lipidogenic pathways |
Human | HADH | 3033 | hydroxyacyl-CoA dehydrogenase | |
Human | GPT | 2875 | glutamic-pyruvate transaminase (alanine aminotransferase) | Type 2 diabetic patients have 80% more liver fat than age-, weight-, and sex-matched nondiabetic subjects, which is underestimated in type 2 diabetics |
Human | GH1 | 2688 | growth hormone 1 | To find out whether the markedly obese patients with Laron syndrome (LS) and GH gene deletion have fatty livers |
Human | DBI | 1622 | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | Data show for the first time in a physiological context that transgenic expression of acyl-coenzyme A binding protein may play a role in liver fatty acyl-coenzyme A metabolism |
Human | CYP2E1 | 1571 | cytochrome P450, family 2, subfamily E, polypeptide 1 | The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver |
Human | BHMT | 635 | betaine--homocysteine S-methyltransferase | betaine-homocysteine methyltransferase (BHMT) transgenic mice are resistant to alcohol or high methionine low folate diet -induced hyperhomocysteinemia and liver steatosis |