Genes (34)
Species: human : 34 | |
Human | INHBE | 83729 | inhibin, beta E | OBJECTIVES: To examine the possible localization and production of activin A in human normal endometrium, endometrial hyperplasia, and adenocarcinoma tissues. | Human | NCOA1 | 8648 | nuclear receptor coactivator 1 | In endometrial hyperplasia, there was a significant correlation between the expression of ER and SRC-1 or p300/CBP. RESULTS: In samples of normal endometria, the expression of coactivators was observed diffusely in glandular cells in the proliferative phase, with a mean positivity index (PI) of 81.8 for SRC-1 and 91.3 for p300/CBP, whereas expression levels decreased in endometrial hyperplasia (PI: SRC-1, 58.9; p300/CBP, 83.8) and endometrial carcinoma (PI: SRC-1, 45.0; p300/CBP, 55.4). BACKGROUND: To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma, expression levels of steroid receptor cofactors, such as coactivators (steroid receptor coactivator 1 [SRC-1] and p300/cyclic AMP-response element-binding protein (p300/CBP]) and corepressors (nuclear receptor corepressor [NCoR] and silencing mediator for retinoid and thyroid-hormone receptors [SMRT]), were investigated. | Human | TP63 | 8626 | tumor protein p63 | METHODS: Immunohistochemical technique was used to detect P53, P63, and C-erbB2 protein expression in 38 cases of EC, 23 cases of endometrial hyperplasia (EH), and 10 cases of benign proliferative endometrium (BPE). | Human | SCGB1A1 | 7356 | secretoglobin, family 1A, member 1 (uteroglobin) | uteroglobin expression is regulated by progesterone in the normal endometrium but regulation by progesterone receptor is lost in endometrial hyperplasia and carcinoma according to acquirement of tumorigenesis | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Endometrial hyperplasia samples did not show increased MT1-MMP or TIMP mRNA expression, indicating that the overall expression patterns in hyperplasia are comparable to those in proliferating endometrium under estrogen effect and that synthesis of extracellular matrix proteins, rather than degradation, predominates in this condition. | Human | TFF3 | 7033 | trefoil factor 3 (intestinal) | Patients harbouring G3-endometrioid endometrial carcinomas had significantly higher TFF3 serum concentration by ELISA when compared with healthy patients or patients harbouring endometrial hyperplasia | Human | TFF1 | 7031 | trefoil factor 1 | Using immunohistochemistry, we examined pS2 expression in 64 samples of endometrial carcinoma, 11 samples of endometrial hyperplasia and 15 samples of normal endometrium, and compared them with clinicopathological data, estrogen receptor (ER) expression and progesterone receptor (PR) expression. All 11 cases of endometrial hyperplasia were strongly positive for pS2. We found a progressive increase in immunoreactivity of pS2 protein from normal endometrium to endometrial hyperplasia and still more in well-differentiated carcinoma. | Human | TERC | 7012 | telomerase RNA component | We conducted a quantitative analysis of TERT, TP1 and hTR mRNA expression in various types of endometrial hyperplasia in perimenopausal women, taking advantage of the real-time PCR assay. The aim of the study was an analysis of the expression profiles of genes encoding hTR and TP1 telomerase subunits in normal endometrium, endometrial hyperplasia, and adenocarcinoma for the estimation of the possibility of once application in endogenous RNA control of gene analysis in the endometrium. | Human | SMO | 6608 | smoothened, frizzled family receptor | RESULTS: The expression of Shh, Ptch, Smo, and Gli1 was very weak in normal endometrium, but was increased in endometrial hyperplasia and carcinoma stepwisely with significant differences. | Human | SFRP4 | 6424 | secreted frizzled-related protein 4 | In addition, the expression of frpHE mRNA is markedly up-regulated in the stroma of endometrial hyperplasia and carcinoma and in the stroma of in situ and infiltrating breast carcinomas. | Human | RARB | 5915 | retinoic acid receptor, beta | the expression level of RAR beta in endometrial carcinoma is significantly lower than that in endometrial hyperplasia | Human | OVGP1 | 5016 | oviductal glycoprotein 1, 120kDa | Gain of oviduct-specific glycoprotein is associated with the development of endometrial hyperplasia and endometrial cancer Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | In this study, there was no immunostaining of normal endometria or of endometrial hyperplasia (including atypical endometrial hyperplasia) to support the hypothesis that expression of the nm23 gene product is related to the development of endometrial adenocarcinoma. There was no immunostaining for nm23 protein in the 10 cases of normal endometria and in the 28 cases of endometrial hyperplasia. In this study, there was no immunostaining of normal endometria or of endometrial hyperplasia (including atypical endometrial hyperplasia) to support the hypothesis that expression of the nm23 gene product is related to the development of endometrial adenocarcinoma. | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | These frequencies of MUC5AC expression did not differ significantly among benign non-hyperplastic endometrium, endometrial hyperplasia and endometrial carcinoma. | Human | MCM3 | 4172 | minichromosome maintenance complex component 3 | The authors investigated the immunohistochemical expression of MCM2 and MCM3, Ki-67, estrogen receptor, and progesterone receptor in 23 normal endometria, 9 endometrial hyperplasias, and 60 endometrial carcinomas. | Human | MCM2 | 4171 | minichromosome maintenance complex component 2 | The authors investigated the immunohistochemical expression of MCM2 and MCM3, Ki-67, estrogen receptor, and progesterone receptor in 23 normal endometria, 9 endometrial hyperplasias, and 60 endometrial carcinomas. | Human | JUP | 3728 | junction plakoglobin | To further study the possible role of cell-to-cell interaction in growth regulation, we immunohistochemically analyzed 80 endometrial samples (30 of normal endometrium, 20 of endometrial hyperplasia, and 30 of endometrial cancer) for the expression of E-cadherin; alpha-, beta-, and gamma-catenin; adenomatous polyposis coli (APC) protein, and sex-steroid hormone receptors at three points in the cells: the cell-to-cell border, the cytoplasm, and the nucleus. | Human | ESR1 | 2099 | estrogen receptor 1 | Findings show that in endometrial hyperplasia and low-grade endometrioid endometrial carcinoma, coordinate increase in cdc25B and phosphorylated ER-alpha occurs | Human | EPHB4 | 2050 | EPH receptor B4 | Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma. | Human | EP300 | 2033 | E1A binding protein p300 | BACKGROUND: To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma, expression levels of steroid receptor cofactors, such as coactivators (steroid receptor coactivator 1 [SRC-1] and p300/cyclic AMP-response element-binding protein (p300/CBP]) and corepressors (nuclear receptor corepressor [NCoR] and silencing mediator for retinoid and thyroid-hormone receptors [SMRT]), were investigated. In endometrial hyperplasia, there was a significant correlation between the expression of ER and SRC-1 or p300/CBP. RESULTS: In samples of normal endometria, the expression of coactivators was observed diffusely in glandular cells in the proliferative phase, with a mean positivity index (PI) of 81.8 for SRC-1 and 91.3 for p300/CBP, whereas expression levels decreased in endometrial hyperplasia (PI: SRC-1, 58.9; p300/CBP, 83.8) and endometrial carcinoma (PI: SRC-1, 45.0; p300/CBP, 55.4). | Human | CYP11A1 | 1583 | cytochrome P450, family 11, subfamily A, polypeptide 1 | cytochrome P450 side chain cleavage mRNA was increased threefold in the ovarian stroma of postmenopausal women with endometrial cancer and endometrial hyperplasia | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | Mutation in exon 3 of the beta-catenin gene was found in 2 of the 20 endometrial cancer samples; however, it was not found in the 25 endometrial hyperplasias or the 20 associated hyperplasias | Human | CREBBP | 1387 | CREB binding protein | In endometrial hyperplasia, there was a significant correlation between the expression of ER and SRC-1 or p300/CBP. RESULTS: In samples of normal endometria, the expression of coactivators was observed diffusely in glandular cells in the proliferative phase, with a mean positivity index (PI) of 81.8 for SRC-1 and 91.3 for p300/CBP, whereas expression levels decreased in endometrial hyperplasia (PI: SRC-1, 58.9; p300/CBP, 83.8) and endometrial carcinoma (PI: SRC-1, 45.0; p300/CBP, 55.4). | Human | CIRBP | 1153 | cold inducible RNA binding protein | Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma. We investigated the immunohistochemical expression of CIRP in 39 endometrial carcinomas, 12 endometrial hyperplasias, and 27 normal endometria using polyclonal antibody against CIRP and confirmed by Western blot analysis. | Human | CHEK1 | 1111 | checkpoint kinase 1 | Somatic frameshift mutations were observed in hMLH3, hMSH3, hMSH6, CHK1, and BAX genes in MSI-H endometrial hyperplasias and cancers, whereas mutations in ATR and CDC25C were observed only in MSI-H ECs. |
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