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Details
Link-It Detail - Disease - DNA Damage
Debug Stats
  • ### Total Build Time: 504 ms 54.603 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 318 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 289 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=2 ms Completed: 2 ms rowSize= 198 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=383 ms Completed: 383 ms rowSize= 14.388 KB
  • CONCEPT_GENES gt=101 ms Completed: 101 ms rowSize= 38.228 KB
  • CONCEPT_XREFS gt=9 ms Completed: 9 ms rowSize= 1.145 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
DNA Damage C0012860
Definition (1)
drug or radiation effects on DNA that interfere with normal function, including conformational distortions and covalent gene mutations.
Semantic Types (1)
Cell or Molecular Dysfunction (T049)
Relationships (312)

Relation Types:
diso_​to_​anat : 37
diso_​to_​chem : 174
diso_​to_​diso : 41
diso_​to_​gene : 2
diso_​to_​phen : 9
diso_​to_​phys : 49


Relationships:
none : 301
biological_​process_​results_​from_​biological_​process : 1
is_​location_​of_​biological_​process : 1
isa : 6
permuted_​term_​of : 1
use : 2
Page Size
Current 25
  Page 1 of 13
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHYS1151img DNA Damage Repair C0012899
DISO_to_PHYS1037img DNA Damage Repair C0012899
DISO_to_CHEM836img DNA C0012854
DISO_to_PHYS625img physiological aspects C0031843
DISO_to_DISO592img Oxidative Stress C0242606
DISO_to_PHEN577img genetic aspects C0017399
DISO_to_CHEM552img DNA C0012854
DISO_to_PHYS472img physiological aspects C0031843
DISO_to_CHEM455img Binding Protein, DNA C0012940
DISO_to_CHEM441img Binding Protein, DNA C0012940
DISO_to_PHEN432img genetic aspects C0017399
DISO_to_DISO388img Oxidative Stress C0242606
DISO_to_PHYS382img Apoptosis C0162638
DISO_to_PHYS379img Apoptosis C0162638
DISO_to_CHEM363img Cell Cycle Protein C0243021
DISO_to_CHEM303img Protein-Serine-Threonine Kinases C0072402
DISO_to_CHEM289img Cell Cycle Protein C0243021
DISO_to_CHEM286img Protein p53 C0080055
DISO_to_CHEM278img Mutagens C0026879
DISO_to_CHEM269img Protein-Serine-Threonine Kinases C0072402
DISO_to_CHEM247img Protein p53 C0080055
DISO_to_CHEM228img Antioxidants C0003402
DISO_to_DISO228img Neoplasms C0027651
DISO_to_PHEN228img Ultraviolet Rays C0041625
DISO_to_CHEM224img Nuclear Proteins C0028589
Genes (305)

Species:
human : 305
Page Size
Current 25
  Page 1 of 13
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanMIR34A407040microRNA 34a
img GENERIF, Score=1000, Pubmed Id: 17554199, UMLKSK CUI: C0012860
HumanLOC391811391811
img GENERIF, Score=901, Pubmed Id: 16479163, UMLKSK CUI: C0012860
HumanSETD8387893SET domain containing (lysine methyltransferase) 8
img GENERIF, Score=1000, Pubmed Id: 18166648, UMLKSK CUI: C0012860
HumanNSMCE2286053non-SMC element 2, MMS21 homolog (S. cerevisiae)
img GENERIF, Score=694, Pubmed Id: 16055714, UMLKSK CUI: C0012860
HumanSPDYA245711speedy/RINGO cell cycle regulator family member A
img GENERIF, Score=1000, Pubmed Id: 12839962, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 16951407, UMLKSK CUI: C0012860
HumanLOC145908145908
img GENERIF, Score=1000, Pubmed Id: 15153943, UMLKSK CUI: C0012860
HumanRAD9B144715RAD9 homolog B (S. pombe)
img GENERIF, Score=1000, Pubmed Id: 16365875, UMLKSK CUI: C0012860
HumanNCOA7135112nuclear receptor coactivator 7
img GENERIF, Score=840, Pubmed Id: 17391516, UMLKSK CUI: C0012860
HumanC19orf4091442chromosome 19 open reading frame 40
img GENERIF, Score=734, Pubmed Id: 18995830, UMLKSK CUI: C0012860
HumanPSRC184722proline/serine-rich coiled-coil 1
img GENERIF, Score=1000, Pubmed Id: 18291097, UMLKSK CUI: C0012860
HumanBRSK184446BR serine/threonine kinase 1
img GENERIF, Score=1000, Pubmed Id: 15150265, UMLKSK CUI: C0012860
HumanFAM175A84142family with sequence similarity 175, member A
img GENERIF, Score=1000, Pubmed Id: 18077395, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 17643121, UMLKSK CUI: C0012860
img GENERIF, Score=734, Pubmed Id: 17525340, UMLKSK CUI: C0012860
HumanATRIP84126ATR interacting protein
img GENERIF, Score=1000, Pubmed Id: 15451423, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 12791985, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 15743907, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 17638878, UMLKSK CUI: C0012860
HumanBRIP183990BRCA1 interacting protein C-terminal helicase 1
img GENERIF, Score=1000, Pubmed Id: 17581638, UMLKSK CUI: C0012860
HumanITCH83737itchy E3 ubiquitin protein ligase
img GENERIF, Score=734, Pubmed Id: 15678106, UMLKSK CUI: C0012860
HumanCDT181620chromatin licensing and DNA replication factor 1
img GENERIF, Score=1000, Pubmed Id: 16407242, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 16861906, UMLKSK CUI: C0012860
img GENERIF, Score=861, Pubmed Id: 18617514, UMLKSK CUI: C0012860
HumanSETD780854SET domain containing (lysine methyltransferase) 7
img GENERIF, Score=1000, Pubmed Id: 17646389, UMLKSK CUI: C0012860
HumanMUS8180198MUS81 structure-specific endonuclease subunit
img GENERIF, Score=1000, Pubmed Id: 17903171, UMLKSK CUI: C0012860
HumanNHEJ179840nonhomologous end-joining factor 1
img GENERIF, Score=901, Pubmed Id: 16439204, UMLKSK CUI: C0012860
HumanSMC679677structural maintenance of chromosomes 6
img GENERIF, Score=694, Pubmed Id: 16055714, UMLKSK CUI: C0012860
HumanMCPH179648microcephalin 1
img GENERIF, Score=694, Pubmed Id: 16872911, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 17925396, UMLKSK CUI: C0012860
HumanBRCC379184BRCA1/BRCA2-containing complex, subunit 3
img GENERIF, Score=1000, Pubmed Id: 18077395, UMLKSK CUI: C0012860
HumanDCLRE1C64421DNA cross-link repair 1C
img GENERIF, Score=1000, Pubmed Id: 17242184, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 15468306, UMLKSK CUI: C0012860
HumanRFWD264326ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
img GENERIF, Score=1000, Pubmed Id: 16931761, UMLKSK CUI: C0012860
HumanCLSPN63967claspin
img GENERIF, Score=660, Pubmed Id: 16934469, UMLKSK CUI: C0012860
img GENERIF, Score=1000, Pubmed Id: 17431426, UMLKSK CUI: C0012860
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0012860DNA Damage0self