Human | MIR34A | 407040 | microRNA 34a | Expression of the primary miR-34a transcript was induced after p53 activation and by DNA damage in a p53-dependent manner |
Human | LOC391811 | 391811 | | p50 might target or anchor p21 to pol delta complex upon certain DNA damage such as adriamycin treatment |
Human | SETD8 | 387893 | SET domain containing (lysine methyltransferase) 8 | Overall, we show that SET8 is essential for genomic stability in mammalian cells and that decreased expression of SET8 results in DNA damage and Chk1-dependent S-phase arrest |
Human | NSMCE2 | 286053 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells |
Human | SPDYA | 245711 | speedy/RINGO cell cycle regulator family member A | This protein mediates protection of mammalian cells against DNA damage This study reports that Spy1 expression allows cells to evade checkpoints and apoptosis and suggest that Spy1 regulation of CDK2 is important for the response to DNA damage |
Human | LOC145908 | 145908 | | The checkpoint kinase 2 plays crucial roles in regulating cell-cycle checkpoints and apoptosis following DNA damage |
Human | RAD9B | 144715 | RAD9 homolog B (S. pombe) | The encoded mammalian proteins participate in promoting resistance to DNA damage, cell cycle checkpoint control, DNA repair, and apoptosis |
Human | NCOA7 | 135112 | nuclear receptor coactivator 7 | NCOA7 encodes the nuclear counterpart of the mitochondrial OXR1 protein and in mammalian cells it may reduce the oxidative by-products of estrogen metabolite-mediated DNA damage |
Human | C19orf40 | 91442 | chromosome 19 open reading frame 40 | DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia |
Human | PSRC1 | 84722 | proline/serine-rich coiled-coil 1 | Together our results show that hDDA3 is a p53- and DNA-damage down-regulated target that exhibits oncogenic characteristics |
Human | BRSK1 | 84446 | BR serine/threonine kinase 1 | acts as checkpoint kinase upon DNA damage induced by UV |
Human | FAM175A | 84142 | family with sequence similarity 175, member A | Abraxas and RAP80 were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair the human Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage |
Human | ATRIP | 84126 | ATR interacting protein | Collectively, our results suggest that the ATR-mediated phosphorylation of ATRIP at Ser-68 and -72 is dispensable for the initial response to DNA damage ATRIP is required for ATR accumulation at intranuclear foci induced by DNA damage ATRIP is a CDK2 substrate, and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling |
Human | BRIP1 | 83990 | BRCA1 interacting protein C-terminal helicase 1 | predicts a broader role for FANCJ in DNA damage signaling independent of BRCA1 |
Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function |
Human | CDT1 | 81620 | chromatin licensing and DNA replication factor 1 | rereplication-associated DNA damage triggers Cdt1 and Cdc6 ubiquitination and destruction; this pathway represents an evolutionarily conserved mechanism that minimizes the extent of rereplication PCNA is involved in mediating Cdt1 degradation by the Cul4-Ddb1 ligase in response to DNA damage L2DTL and PCNA interact with CUL4/DDB1 complexes and are involved in CDT1 degradation after DNA damage |
Human | SETD7 | 80854 | SET domain containing (lysine methyltransferase) 7 | Results suggest that the cross talk between lysine methylation and acetylation is critical for p53 activation in response to DNA damage and that Set7/9 may play an important role in tumor suppression |
Human | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells |
Human | NHEJ1 | 79840 | nonhomologous end-joining factor 1 | Cernunnos-XLF is a new Non-homologous End Joining pathway protein, which if mutated results in several conditions -immunodeficiency and developmental anomalies and other conditions, which likely result from inability to repair spontaneous DNA damage |
Human | SMC6 | 79677 | structural maintenance of chromosomes 6 | the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells |
Human | MCPH1 | 79648 | microcephalin 1 | BRIT1 is a crucial DNA damage regulator in the ATM/ATR pathways and suggest that it functions as a tumor suppressor gene MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage |
Human | BRCC3 | 79184 | BRCA1/BRCA2-containing complex, subunit 3 | the human Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage |
Human | DCLRE1C | 64421 | DNA cross-link repair 1C | ATM regulates G(2)/M checkpoint recovery through inhibitory phosphorylations of Artemis that occur soon after DNA damage, thus setting a molecular switch that, hours later upon completion of DNA repair, allows activation of the Cdk1-cyclin B complex Atemis is an effector of dna repair that can be phosphorylated by ataxia-telangiectasia-mutated kinase (ATM) and possibly by DNA-dependent protein kinase catalytic subunit and ATM-and Rad3-related kinase depending on the type of DNA damage |
Human | RFWD2 | 64326 | ring finger and WD repeat domain 2, E3 ubiquitin protein ligase | in response to DNA damage, ATM phosphorylated COP1 on Ser(387) and stimulated a rapid autodegradation mechanism; ionizing radiation triggered an ATM-dependent movement of COP1 from the nucleus to the cytoplasm |
Human | CLSPN | 63967 | claspin | The degradation of Claspin at the onset of mitosis is an essential step for the recovery of a cell from a DNA-damage-induced cell-cycle arrest downregulation of Claspin protein levels by short interfering RNA resulted in an increase in apoptotic induction both in the presence and absence of DNA damage |