Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | reported a positive association of the SUMO4 M55V variant with diabetic nephropathy in an Asian cohort of 430 patients with type 2 diabetes SUMO4 gene methionine-valine variant is associated with severity of diabetic nephropathy in patients with type 2 diabetes |
Human | PLEKHH2 | 130271 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | PLEKHH2, which has mRNA and protein expression exclusively in the glomerulus, may be a genetic risk factor for susceptibility to diabetic nephropathy in the diabetic population |
Human | APOA5 | 116519 | apolipoprotein A-V | The strong association between triglyceride level in diabetic nephropathy is not affected by apoA5 polymorphism |
Human | CNDP1 | 84735 | carnosine dipeptidase 1 (metallopeptidase M20 family) | Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes CN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients This replicates the CNDP1 gene association with diabetic nephropathy (DN) that was initially detected in European Caucasians and in Arabs, and further demonstrates that the CNDP1 gene and carnosine pathway appear to play a role in susceptibility to DN Diabetic patients homozygous for CNDP1 are protected against diabetic nephropathy |
Human | NCALD | 83988 | neurocalcin delta | association of the landmark SNP with the progression of diabetic nephropathy in a 8-year prospective study |
Human | XYLT2 | 64132 | xylosyltransferase II | xylotransferase genes might be potential candidate genes predisposing to diabetic nephropathy in type 1 diabetic patients |
Human | XYLT1 | 64131 | xylosyltransferase I | xylotransferase genes might be potential candidate genes predisposing to diabetic nephropathy in type 1 diabetic patients The XYLT-I c.343G>T polymorphism contributes to the genetic susceptibility to development of diabetic nephropathy in type 1 diabetic patients |
Human | ACE2 | 59272 | angiotensin I converting enzyme 2 | a decrease in ACE2 may be involved in diabetic kidney disease--REVIEW Relationship between urinary mRNA expression of ACE2 and the degree of proteinuria in type 2 diabetic nephropathy In Finnish type 1 diabetic patients, ACE2 polymorphisms are not associated with diabetic nephropathy or any studied risk factor for this complication |
Human | LRRC7 | 57554 | leucine rich repeat containing 7 | common variants in LRRC7, KIRREL, NPHS2 and ACTN4 do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes |
Human | CNDP2 | 55748 | CNDP dipeptidase 2 (metallopeptidase M20 family) | Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes |
Human | KIRREL | 55243 | kin of IRRE like (Drosophila) | common variants in LRRC7, KIRREL, NPHS2 and ACTN4 do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes |
Human | THG1L | 54974 | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) | induced in high glucose-1 (IHG-1)which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | preproghrelin 72Met carrier status may be used as a marker predicting a lower chance of developing renal dysfunction in diabetic nephropathy |
Human | NOX3 | 50508 | NADPH oxidase 3 | Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26) |
Human | ANKRD1 | 27063 | ankyrin repeat domain 1 (cardiac muscle) | CARP was expressed in renal podocytes at a high level in 10 of 13 cases of crescentic glomerulonephritis, 7 of 19 cases of diabetic nephropathy, and 12 of 20 cases of lupus nephritis |
Human | GREM1 | 26585 | gremlin 1, DAN family BMP antagonist | TFG-beta is an inducer of gremlin expression in diabetic nephropathy Notch pathway gene expression is elevated in diabetic nephropathy, co-incident with Gremlin, and may contribute to the pathogenesis of this dise |
Human | HPSE | 10855 | heparanase | HPSE is involved in the pathogenesis of proteinuria in overt diabetic nephropathy by degradation of heparan sulfates Loss of heparan sulfsate in the glomerular basement membrane in diabetic nephropathy is attributable to accelerated heparan sulfate degradation by increased HPR1 expression |
Human | ELMO1 | 9844 | engulfment and cell motility 1 | These results indicate that ELMO1 is a novel candidate gene that both confers susceptibility to diabetic nephropathy and plays an important role in the development and progression of this disease |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Plasma levels may be involed in the development of vascular complication in end stage of diabetic nephropathy |
Human | TSC22D1 | 8848 | TSC22 domain family, member 1 | findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | TRAIL-induced cell death could play an important role in the progression of human diabetic nephropathy |
Human | NPHS2 | 7827 | nephrosis 2, idiopathic, steroid-resistant (podocin) | common variants in LRRC7, KIRREL, NPHS2 and ACTN4 do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Click here to display 6 evidence detail records. |
Human | UCP3 | 7352 | uncoupling protein 3 (mitochondrial, proton carrier) | Association between BMI and the UCP3 -55 C-->T polymorphism in diabetic nephropathy |
Human | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | No association between the different polymorphisms and diabetic nephropathy |