Human | LOC100507436 | 100507436 | | Click here to display 10 evidence detail records. |
Human | KIR2DS2 | 100132285 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | Title:|Association:Y|Conclusion:Not Found Title:Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls.|Association:Not Found|Conclusion:In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM. |
Human | ZGLP1 | 100125288 | zinc finger, GATA-like protein 1 | A disturbed GLP-1 secretion does not play a role in blunting the insulin response observed in patients with diabetes and liver cirrhosis |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Polymorphisms of chemokine and chemokine receptor genes in Type 1 diabetes mellitus and its complications.|Association:Y|Conclusion:These results suggest that polymorphisms of the MCP-1, CCR2 and CCR5 genes may be associated with T1DM and its complications. |
Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | Title:Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population.|Association:Not Found|Conclusion:IDDM3, IDDM4, IDDM5 but not IDDM8 may be associated with IDDM in Chinese Han nationality population. Title:|Association:Y|Conclusion:Not Found |
Human | ZFP57 | 346171 | ZFP57 zinc finger protein | Late predisposition to type 2 (insulin resistant) diabetes |
Human | VWA2 | 340706 | von Willebrand factor A domain containing 2 | Single nucleotide polymorphisms in the AMACO gene are associated with dominant protection against Type 1A diabetes in an Arab family |
Human | CRTC2 | 200186 | CREB regulated transcription coactivator 2 | Dysregulation of the TSC-mTOR pathway may cause not only tumor development but also metabolic disorders such as diabetes and its comp |
Human | PPARGC1B | 133522 | peroxisome proliferator-activated receptor gamma, coactivator 1 beta | Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration |
Human | CYP2R1 | 120227 | cytochrome P450, family 2, subfamily R, polypeptide 1 | Title:CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans|Association:Y|Conclusion:Thus, our findings reveal a novel association of CYP2R1 polymorphisms in patients with type 1 diabetes and with their circulating levels of 25(OH)D(3). |
Human | APOA5 | 116519 | apolipoprotein A-V | APOA5 could also influence cholesterol homeostasis and probably play a role in hypertriglyceridemia associated with diabetes and inflammation |
Human | Gma3 | 110204 | granulocyte macrophage antigen 3 | Title:|Association:Not Found|Conclusion:Not Found |
Human | DGAT2 | 84649 | diacylglycerol O-acyltransferase 2 | Overexpression of human DGAT2 in glycolytic muscle of mice promotes insulin resistance in this tissue and may contribute to the development of diabetes |
Human | PCBD2 | 84105 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | Title:|Association:Not Found|Conclusion:Not Found |
Human | SETD7 | 80854 | SET domain containing (lysine methyltransferase) 7 | a novel role for SET7/9 in inflammation and diabetes |
Human | ADIPOR2 | 79602 | adiponectin receptor 2 | Upregulation in endothelial cells potentiates the antiinflammatory effect of adiponectin, which may apply to cardiovascular complcation in diabetes Title:|Association:Not Found|Conclusion:Not Found |
Human | FTO | 79068 | fat mass and obesity associated | A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO gene that predisposes to diabetes through an effect on body mass index |
Human | HPSE2 | 60495 | heparanase 2 | Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria |
Human | HRH4 | 59340 | histamine receptor H4 | Results describe the expression of histamine H4 receptors in normal placentas and in placentas from pregnancies complicated by pregestational diabetes |
Human | G6PC2 | 57818 | glucose-6-phosphatase, catalytic, 2 | Alpha mutants containing the beta cell antigen sequence are preferentially degraded in cells, which prevents targeting by pathogenic CD8+ T cells implying that IGRP levels in beta cells could dictate susceptibilities to diabetes |
Human | HYMAI | 57061 | hydatidiform mole associated and imprinted (non-protein coding) | Late predisposition to type 2 (insulin resistant) diabetes imprinted in transient neonatal diabetes |
Human | RETN | 56729 | resistin | In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes Resistin inhibition may not represent a suitable therapeutic strategy for the treatment of insulin resistance and diabetes in patients with liver cirrhosis Title:Systematic search for single nucleotide polymorphisms in the resistin gene: the absence ofevidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.|Association:Not Found|Conclusion:These identified SNPs, which were in linkage disequilibrium, represent potentially useful tools for searching for their association with specific phenotypes of diabetes. Title:|Association:Not Found|Conclusion:Not Found |
Human | CDKAL1 | 54901 | CDK5 regulatory subunit associated protein 1-like 1 | Diabetes-associated variants in TCF7L2 and CDKAL1 impair insulin secretion and conversion of proinsulin to insulin |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Title:Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus.|Association:Not Found|Conclusion:The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients. Leu72Met polymorphism was, however, associated with serum creatinine and Lp(a) levels in diabetic patients. The mechanism might be associated with a possible change in ghrelin product and its somatotropic effect. |
Human | KLF13 | 51621 | Kruppel-like factor 13 | Title:Single nucleotide polymorphisms in the gene encoding Kr????ppel-like factor 7 are associated with type 2 diabetes.|Association:Not Found|Conclusion:These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes. |