GATACA

Credits

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Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Diabetes

Debug Stats

### Total Build Time: 92 ms 36.778 KB
CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 314 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
Skipping details on: CONCEPT_DEFINITION gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=2 ms Completed: 2 ms rowSize= 106 bytes
CONCEPT_GENES gt=89 ms Completed: 89 ms rowSize= 35.155 KB
CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.143 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Diabetes C0011847

Genes (381)

Species:

human : 381

Page Size

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Species	Gene	GeneId	Gene Name	Evidence
Human	LOC100507436	100507436		Click here to display 10 evidence detail records.
Human	KIR2DS2	100132285	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	GAD, Score=1000, Pubmed Id: 14514651, UMLKSK CUI: C0011847 Title:\|Association:Y\|Conclusion:Not Found GAD, Score=1000, Pubmed Id: 15699512, UMLKSK CUI: C0011847 Title:Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls.\|Association:Not Found\|Conclusion:In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM.
Human	ZGLP1	100125288	zinc finger, GATA-like protein 1	GENERIF, Score=1000, Pubmed Id: 18770489, UMLKSK CUI: C0011847 A disturbed GLP-1 secretion does not play a role in blunting the insulin response observed in patients with diabetes and liver cirrhosis
Human	CCR2	729230	chemokine (C-C motif) receptor 2	GAD, Score=1000, Pubmed Id: 15135805, UMLKSK CUI: C0011847 Title:Polymorphisms of chemokine and chemokine receptor genes in Type 1 diabetes mellitus and its complications.\|Association:Y\|Conclusion:These results suggest that polymorphisms of the MCP-1, CCR2 and CCR5 genes may be associated with T1DM and its complications.
Human	SUMO4	387082	small ubiquitin-like modifier 4	GAD, Score=1000, Pubmed Id: 12901503, UMLKSK CUI: C0011847 Title:Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population.\|Association:Not Found\|Conclusion:IDDM3, IDDM4, IDDM5 but not IDDM8 may be associated with IDDM in Chinese Han nationality population. GAD, Score=1000, Pubmed Id: 15123604, UMLKSK CUI: C0011847 Title:\|Association:Y\|Conclusion:Not Found
Human	ZFP57	346171	ZFP57 zinc finger protein	OMIM, Score=1000, UMLKSK CUI: C0011847 Late predisposition to type 2 (insulin resistant) diabetes
Human	VWA2	340706	von Willebrand factor A domain containing 2	GENERIF, Score=827, Pubmed Id: 15699509, UMLKSK CUI: C0011847 Single nucleotide polymorphisms in the AMACO gene are associated with dominant protection against Type 1A diabetes in an Arab family
Human	CRTC2	200186	CREB regulated transcription coactivator 2	GENERIF, Score=1000, Pubmed Id: 18926585, UMLKSK CUI: C0011847 Dysregulation of the TSC-mTOR pathway may cause not only tumor development but also metabolic disorders such as diabetes and its comp
Human	PPARGC1B	133522	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	GENERIF, Score=1000, Pubmed Id: 17018837, UMLKSK CUI: C0011847 Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration
Human	CYP2R1	120227	cytochrome P450, family 2, subfamily R, polypeptide 1	GAD, Score=1000, Pubmed Id: 17607662, UMLKSK CUI: C0011847 Title:CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans\|Association:Y\|Conclusion:Thus, our findings reveal a novel association of CYP2R1 polymorphisms in patients with type 1 diabetes and with their circulating levels of 25(OH)D(3).
Human	APOA5	116519	apolipoprotein A-V	GENERIF, Score=1000, Pubmed Id: 16448983, UMLKSK CUI: C0011847 APOA5 could also influence cholesterol homeostasis and probably play a role in hypertriglyceridemia associated with diabetes and inflammation
Human	Gma3	110204	granulocyte macrophage antigen 3	GAD, Score=1000, Pubmed Id: 3177389, UMLKSK CUI: C0011847 Title:\|Association:Not Found\|Conclusion:Not Found
Human	DGAT2	84649	diacylglycerol O-acyltransferase 2	GENERIF, Score=1000, Pubmed Id: 17940217, UMLKSK CUI: C0011847 Overexpression of human DGAT2 in glycolytic muscle of mice promotes insulin resistance in this tissue and may contribute to the development of diabetes
Human	PCBD2	84105	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	GAD, Score=1000, Pubmed Id: 10096793, UMLKSK CUI: C0011847 Title:\|Association:Not Found\|Conclusion:Not Found
Human	SETD7	80854	SET domain containing (lysine methyltransferase) 7	GENERIF, Score=1000, Pubmed Id: 18650421, UMLKSK CUI: C0011847 a novel role for SET7/9 in inflammation and diabetes
Human	ADIPOR2	79602	adiponectin receptor 2	GENERIF, Score=1000, Pubmed Id: 18988888, UMLKSK CUI: C0011847 Upregulation in endothelial cells potentiates the antiinflammatory effect of adiponectin, which may apply to cardiovascular complcation in diabetes GAD, Score=1000, Pubmed Id: 15983228, UMLKSK CUI: C0011847 Title:\|Association:Not Found\|Conclusion:Not Found
Human	FTO	79068	fat mass and obesity associated	GENERIF, Score=1000, Pubmed Id: 17434869, UMLKSK CUI: C0011847 A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO gene that predisposes to diabetes through an effect on body mass index
Human	HPSE2	60495	heparanase 2	GENERIF, Score=660, Pubmed Id: 18058084, UMLKSK CUI: C0011847 Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria
Human	HRH4	59340	histamine receptor H4	GENERIF, Score=861, Pubmed Id: 17806168, UMLKSK CUI: C0011847 Results describe the expression of histamine H4 receptors in normal placentas and in placentas from pregnancies complicated by pregestational diabetes
Human	G6PC2	57818	glucose-6-phosphatase, catalytic, 2	GENERIF, Score=1000, Pubmed Id: 16012821, UMLKSK CUI: C0011847 Alpha mutants containing the beta cell antigen sequence are preferentially degraded in cells, which prevents targeting by pathogenic CD8+ T cells implying that IGRP levels in beta cells could dictate susceptibilities to diabetes
Human	HYMAI	57061	hydatidiform mole associated and imprinted (non-protein coding)	OMIM, Score=1000, UMLKSK CUI: C0011847 Late predisposition to type 2 (insulin resistant) diabetes GENERIF, Score=827, Pubmed Id: 11935319, UMLKSK CUI: C0011847 imprinted in transient neonatal diabetes
Human	RETN	56729	resistin	GAD, Score=1000, Pubmed Id: 11872693, UMLKSK CUI: C0011847 Title:Systematic search for single nucleotide polymorphisms in the resistin gene: the absence ofevidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.\|Association:Not Found\|Conclusion:These identified SNPs, which were in linkage disequilibrium, represent potentially useful tools for searching for their association with specific phenotypes of diabetes. GENERIF, Score=861, Pubmed Id: 17785630, UMLKSK CUI: C0011847 In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes GAD, Score=1000, Pubmed Id: 12050208, UMLKSK CUI: C0011847 Title:\|Association:Not Found\|Conclusion:Not Found GENERIF, Score=1000, Pubmed Id: 16478779, UMLKSK CUI: C0011847 Resistin inhibition may not represent a suitable therapeutic strategy for the treatment of insulin resistance and diabetes in patients with liver cirrhosis
Human	CDKAL1	54901	CDK5 regulatory subunit associated protein 1-like 1	GENERIF, Score=660, Pubmed Id: 18264689, UMLKSK CUI: C0011847 Diabetes-associated variants in TCF7L2 and CDKAL1 impair insulin secretion and conversion of proinsulin to insulin
Human	GHRL	51738	ghrelin/obestatin prepropeptide	GAD, Score=1000, Pubmed Id: 12974878, UMLKSK CUI: C0011847 Title:Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus.\|Association:Not Found\|Conclusion:The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients. Leu72Met polymorphism was, however, associated with serum creatinine and Lp(a) levels in diabetic patients. The mechanism might be associated with a possible change in ghrelin product and its somatotropic effect.
Human	KLF13	51621	Kruppel-like factor 13	GAD, Score=1000, Pubmed Id: 15937668, UMLKSK CUI: C0011847 Title:Single nucleotide polymorphisms in the gene encoding Kr????ppel-like factor 7 are associated with type 2 diabetes.\|Association:Not Found\|Conclusion:These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0011847	Diabetes	0		self

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