Human | NPSR1 | 387129 | neuropeptide S receptor 1 | the GPRA gene does not contribute to the shared genetic predisposition of atopic dermatitis and allergic airways disease |
Human | IL31 | 386653 | interleukin 31 | Findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis serum IL-31 levels were significantly higher in patients with atopic dermatitis (AD) compared with control subjects; findings provide evidence that IL-31 has a role in AD pathophysiology with regard to pruritus and skin inflammation IL-31 expression is associated with CLA(+) T cells and might contribute to the development of atopic dermatitis-induced skin inflammation and pruritus |
Human | COL6A5 | 256076 | collagen, type VI, alpha 5 | To identify the underlying atopic dermatitis disease gene, a dense map of microsatellite markers and single nucleotide polymorphisms was used, and association with AD was detected |
Human | DCD | 117159 | dermcidin | Reduced expression of dermcidin in sweat of patients with atopic dermatitis may contribute to the high susceptibility of these patients to skin infections and altered skin colonization with Staphylococcus aureus |
Human | TSLP | 85480 | thymic stromal lymphopoietin | A TSLP-driven mouse model of inflammation exhibits many characteristics of human atopic dermatitis, including infiltrate of CD4-positive cells, eosinophils, mast cells; production of Th2 cytokines; and class switching to produce immunoglobulin E |
Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients |
Human | ADM2 | 79924 | adrenomedullin 2 | IMD expressed by pericytes in has a role in susceptibility of the skin of atopic dermatitis patients to inflammatory stimuli |
Human | DEFB103B | 55894 | defensin, beta 103B | As compared to healthy controls, skin of patients with mycosis fungoides (non-lesional and lesional) and atopic dermatitis patients showed significantly lower hBD-1 mRNA expression and significantly higher hBD-2 and hBD-3 mRNA expression |
Human | TLR9 | 54106 | toll-like receptor 9 | the TLR9 promoter polymorphism C-1237T might affect atopic eczema susceptibility in particular in patients with the intrinsic variant of AE |
Human | PHF11 | 51131 | PHD finger protein 11 | Title:|Association:Y|Conclusion:Not Found |
Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | Our results strongly suggest that the 5383_5397del variation site of Tim-1 exon 4 might be associated with atopic dermatitis susceptibility |
Human | GPR44 | 11251 | prostaglandin D2 receptor 2 | Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis |
Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | SPINK5's role in atopic dermatitis and skin diseases is described Title:|Association:Y|Conclusion:Not Found Title:Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population.|Association:Y|Conclusion:This study confirms the previous suggestion of an association between SPINK5 and AD. There is an association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese |
Human | CCL27 | 10850 | chemokine (C-C motif) ligand 27 | serum levels significantly correlated with disease activity in patients with atopic dermatitis primary Th2-dominated inflammatory reaction in atopic dermatitis induced by TARC leads to an augmented skin-specific inflammatory reaction through CTACK |
Human | CYSLTR1 | 10800 | cysteinyl leukotriene receptor 1 | The 927T>C CYSLTR1 SNP was analyzed by direct sequencing after PCR amplification in childres with asthma and atopic dermatitis |
Human | TBC1D4 | 9882 | TBC1 domain family, member 4 | KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells in atopic dermatitis |
Human | IL1RL1 | 9173 | interleukin 1 receptor-like 1 | The -26999A allele of ST2 is correlated with an increased risk for atopic dermatitis |
Human | TNFSF18 | 8995 | tumor necrosis factor (ligand) superfamily, member 18 | Since regulatory T-cells are localized in the vicinity of GITRL-expressing cells in atopic dermatitis skin, the GITR/GITRL interaction may serve to perpetuate the inflammation locally |
Human | TNFRSF14 | 8764 | tumor necrosis factor receptor superfamily, member 14 | sHVEM levels were elevated in sera of patients with allergic asthma, atopic dermatitis and rheumatoid arthritis |
Human | EPX | 8288 | eosinophil peroxidase | No variation in genes eosinophil peroxidase for Atopic dermatitis pathogenesis in this German cohort |
Human | VIP | 7432 | vasoactive intestinal peptide | Atopic dermatitis patients' VIP levels were elevated not only in the skin but also in the serum, suggesting that increased serum levels in might be involved in its pathogenesis |
Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF 121 isoform that exclusively induces hyperpermeability of blood vessels was a predominant component in the lesional scales suggesting that this factor plays an important role in the persisting erythema and edema in the atopic dermatitis lesions |
Human | TNF | 7124 | tumor necrosis factor | interleukin-16 production is impaired in monocyte-derived dendritic cells from atopic dermatitis patients but is restored by inflammatory cytokines TNF-alpha and IL-1beta |
Human | TLR2 | 7097 | toll-like receptor 2 | The outcome of innate and adaptive immune responses in atopic dermatitis is modulated by the Toll-like receptor 2 Arg753Gln single nucleotide polymorphism The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype Proinflammatory monocytes, from patients with atopic dermatitis, are functionally defective in their capacity to produce proinflammatory cytokines on TLR2 stimuli in part because of the high levels of their Fc epsilon RI expression findings show functional difference in TLR-2 responsiveness of monocytes from atopic dermatitis (AD) patients with TLR-2 R753Q mutation compared with wild type AD patients; TLR-2 may be essential in pathogenesis & maintenance of AD |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:|Association:Y|Conclusion:TGFB1 genotype may partly explain the strong genetic predisposition to AD. |