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Details
Link-It Detail - Disease - Depressive Disorder
Debug Stats
  • ### Total Build Time: 985 ms 50.917 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 336 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.737 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 201 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 550 bytes
  • CONCEPT_CHILDREN gt=9 ms Completed: 9 ms rowSize= 1.842 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.492 KB
  • CONCEPT_RELATIONSHIPS gt=868 ms Completed: 868 ms rowSize= 14.644 KB
  • CONCEPT_GENES gt=81 ms Completed: 81 ms rowSize= 28.960 KB
  • CONCEPT_XREFS gt=7 ms Completed: 7 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Depressive Disorder C0011581
Definition (1)

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include

  • Sadness
  • Loss of interest or pleasure in activities you used to enjoy
  • Change in weight
  • Difficulty sleeping or oversleeping
  • Energy loss
  • Feelings of worthlessness
  • Thoughts of death or suicide

Depression is a disorder of the brain. There are a variety of causes, including genetic, environmental, psychological, and biochemical factors. Depression usually starts between the ages of 15 and 30, and is much more common in women. Women can also get postpartum depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder.

There are effective treatments for depression, including antidepressants and talk therapy. Most people do best by using both.

NIH: National Institute of Mental Health

Semantic Types (1)
Mental or Behavioral Dysfunction (T048)
Parents (1)
img Mood Disorders C0525045
Children (4)
img Dysthymic Disorder C0013415
img Depression, Postpartum C0221074
img Depressive Disorder, Major C1269683
img Seasonal Affective Disorder C0085159
Ancestral Roots
RootRoot Plus OneDepthParent
img Mental Disorders C0004936img Mood Disorders C05250453img Mood Disorders C0525045
Relationships (567)

Relation Types:
diso_​to_​anat : 14
diso_​to_​chem : 383
diso_​to_​diso : 132
diso_​to_​gene : 1
diso_​to_​phen : 4
diso_​to_​phys : 33


Relationships:
none : 190
clinically_​similar : 1
isa : 26
may_​diagnose : 33
may_​treat : 309
permuted_​term_​of : 1
related_​to : 6
used_​for : 1
Page Size
Current 25
  Page 1 of 23
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO1153img Anxiety Disorders C0003469
DISO_to_CHEM980img Antidepressive Agents C0003289
DISO_to_CHEM821img Antidepressive Agents C0003289
DISO_to_DISO723img Complication Aspects C1171258
DISO_to_DISO560img Complication Aspects C1171258
DISO_to_DISO554img Anxiety Disorders C0003469
DISO_to_DISO539img Depression C0011570
DISO_to_PHEN462img genetic aspects C0017399
DISO_to_CHEM381img Serotonin Uptake Inhibitors C0162758
DISO_to_DISO317img Life Stress C0038443
DISO_to_DISO279img Bipolar Disorder C0005586
DISO_to_DISO244img Bipolar Disorder C0005586
DISO_to_PHEN243img genetic aspects C0017399
DISO_to_DISO241img Depression C0011570
DISO_to_CHEM240img Serotonin Uptake Inhibitors C0162758
DISO_to_CHEM224img Agents, Second-Generation Antidepressive C0242905
DISO_to_DISO213img Cognition Disorders C0009241
DISO_to_DISO210img Suicide C0038661
DISO_to_ANAT199img In Blood C0005768
DISO_to_DISO197img Suicide C0038661
DISO_to_DISO180img Post-Traumatic Stress Disorder C0038436
DISO_to_ANAT178img Brain C0006104
DISO_to_ANAT174img In Blood C0005768
DISO_to_PHYS174img Anxiety C0003467
DISO_to_DISO167img Pregnancy Complications C0032962
Genes (157)

Species:
human : 157
Page Size
Current 25
  Page 1 of 7
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCD24100133941CD24 molecule
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanPARK12677662Parkinson disease 12 (susceptibility)
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanDAOA267012D-amino acid oxidase activator
INFERRED, Score=800, UMLKSK CUI: C0011581
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
INFERRED, Score=800, UMLKSK CUI: C0011581
HumanPARK10170534Parkinson disease 10 (susceptibility)
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanC5orf20140947chromosome 5 open reading frame 20
INFERRED, Score=800, UMLKSK CUI: C0011581
HumanTPH2121278tryptophan hydroxylase 2
img GENERIF, Score=1000, Pubmed Id: 17192895, UMLKSK CUI: C0011581
img GENERIF, Score=1000, Pubmed Id: 16936760, UMLKSK CUI: C0011581
img GAD, Score=1000, Pubmed Id: 15124006, UMLKSK CUI: C0011581
img GAD, Score=1000, Pubmed Id: 15052272, UMLKSK CUI: C0011581
HumanDTNBP184062dystrobrevin binding protein 1
img GENERIF, Score=1000, Pubmed Id: 18797396, UMLKSK CUI: C0011581
HumanPANK280025pantothenate kinase 2
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanPINK165018PTEN induced putative kinase 1
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanJPH357338junctophilin 3
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanC10orf256652chromosome 10 open reading frame 2
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanGMIP51291GEM interacting protein
img GAD, Score=1000, Pubmed Id: 16086184, UMLKSK CUI: C0011581
HumanGAL51083galanin/GMAP prepropeptide
img GENERIF, Score=1000, Pubmed Id: 12769595, UMLKSK CUI: C0011581
HumanPDE11A50940phosphodiesterase 11A
img OMIM, Score=1000, UMLKSK CUI: C0011581
img GENERIF, Score=1000, Pubmed Id: 18043711, UMLKSK CUI: C0011581
HumanDISC127185disrupted in schizophrenia 1
img GENERIF, Score=1000, Pubmed Id: 17823207, UMLKSK CUI: C0011581
HumanUQCRQ27089ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanFGF2026281fibroblast growth factor 20
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanATXN1025814ataxin 10
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanDKK122943dickkopf WNT signaling pathway inhibitor 1
img GENERIF, Score=1000, Pubmed Id: 18571836, UMLKSK CUI: C0011581
HumanTPPP11076tubulin polymerization promoting protein
img GENERIF, Score=804, Pubmed Id: 18311157, UMLKSK CUI: C0011581
HumanMED129968mediator complex subunit 12
INFERRED, Score=800, UMLKSK CUI: C0011581
HumanSNCAIP9627synuclein, alpha interacting protein
img OMIM, Score=1000, UMLKSK CUI: C0011581
HumanCLOCK9575clock circadian regulator
img GENERIF, Score=1000, Pubmed Id: 17221848, UMLKSK CUI: C0011581
img GAD, Score=1000, Pubmed Id: 15475734, UMLKSK CUI: C0011581
HumanHTR3B91775-hydroxytryptamine (serotonin) receptor 3B, ionotropic
INFERRED, Score=800, UMLKSK CUI: C0011581
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0011581Depressive Disorder0self