Human | CD209 | 30835 | CD209 molecule | The promoter variant DC-SIGN1-336 confers protection against the severity of dengue by affecting transcription factor Sp1 binding Title:A variant in the CD209 promoter is associated with severity of dengue disease.|Association:Y|Conclusion:These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies. |
Human | IL1RL1 | 9173 | interleukin 1 receptor-like 1 | We suggest that sST2 could be a potential marker of dengue infection, could be associated with severity or could play a role in the immune response in secondary dengue virus infection |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | These data suggest that TRAIL plays an important role in the antiviral response to dengue virus (DV) infection and is a candidate for antiviral interventions against DV Dengue virus infection promotes apoptosis in hepatic cells partly through the induction of Apo2L/TRAIL expression |
Human | IL1R2 | 7850 | interleukin 1 receptor, type II | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | VEGFA | 7422 | vascular endothelial growth factor A | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | sVCAM-1 was associated with dengue disease severity and the time post infection; a significant difference was found in the plasma levels of sVCAM-1 between dengue shock syndrome and dengue fever patients |
Human | TNF | 7124 | tumor necrosis factor | TNF-alpha may have a role in endothelial cell damage in dengue |
Human | THPO | 7066 | thrombopoietin | thrombocytopenia in dengue disease is associated with changes in the serum levels of thrombopoietin, but not interleukin-11 |
Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | First report on the role of TAP2 polymorphisms involved in the diverse pathogenesis of dengue virus infection |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | SSB | 6741 | Sjogren syndrome antigen B (autoantigen La) | La protein binds to the 5' end and with the 3' UTR of Dengue virus RNA; interacts with the dengue virus nonstructural proteins NS5 and NS3 |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | RAB5A | 5868 | RAB5A, member RAS oncogene family | Rab 5 is required for the cellular entry of dengue and West Nile viruses |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoterpolymorphism.|Association:Not Found|Conclusion:These data suggest that the 4G/5G polymorphism has no significant influence on PAI-1 concentrations in dengue virus infected patients and is not associated with the risk of death from dengue. Other factors contributing to the variability of PAI-1 plasma concentrations in patients with dengue need to be explored. |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Dengue Virus-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection |
Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | significant correlations between wild-type AA MBL2 genotype and age as associated risk factors for development of dengue-related thrombocytopenia |
Human | IL11 | 3589 | interleukin 11 | thrombocytopenia in dengue disease is associated with changes in the serum levels of thrombopoietin, but not interleukin-11 |
Human | IL10 | 3586 | interleukin 10 | The association of increased levels of IL-10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease |
Human | IL4 | 3565 | interleukin 4 | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | IL1R1 | 3554 | interleukin 1 receptor, type I | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | INFERRED, Score=800, UMLKSK CUI: C0011311 |
Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | INFERRED, Score=800, UMLKSK CUI: C0011311 |