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Details
Link-It Detail - Disease - Demyelinating Diseases
Debug Stats
  • ### Total Build Time: 220 ms 39.341 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 342 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 523 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 559 bytes
  • CONCEPT_CHILDREN gt=17 ms Completed: 17 ms rowSize= 3.217 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.115 KB
  • CONCEPT_RELATIONSHIPS gt=139 ms Completed: 139 ms rowSize= 13.486 KB
  • CONCEPT_GENES gt=56 ms Completed: 56 ms rowSize= 18.765 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.156 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Demyelinating Diseases C0011303
Definition (1)
A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Nervous System Diseases C0027765
Children (7)
img Subacute Combined Degeneration C0221065
img Hereditary Central Nervous System Demyelinating Diseases C0751877
img Demyelinating Autoimmune Diseases, CNS C0751873
img Leukoencephalopathy, Progressive Multifocal C0023524
img Myelinolysis, Central Pontine C0206083
img Polyradiculoneuropathy C0032587
img Marchiafava-Bignami Disease C0238265
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C00277652img Nervous System Diseases C0027765
Relationships (113)

Relation Types:
diso_​to_​anat : 34
diso_​to_​chem : 16
diso_​to_​diso : 54
diso_​to_​phen : 2
diso_​to_​phys : 7


Relationships:
none : 103
is_​associated_​anatomic_​site_​of : 2
isa : 2
mapped_​to : 5
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO177img chemically induced C0007994
DISO_to_PHEN122img genetic aspects C0017399
DISO_to_ANAT117img Myelin Sheath C0026973
DISO_to_DISO117img Multiple Sclerosis C0026769
DISO_to_DISO112img Complication Aspects C1171258
DISO_to_PHEN106img genetic aspects C0017399
DISO_to_ANAT95img Brain C0006104
DISO_to_DISO86img chemically induced C0007994
DISO_to_DISO83img Complication Aspects C1171258
DISO_to_ANAT79img Myelinated nerve fiber C0027750
DISO_to_ANAT72img Myelin Sheath C0026973
DISO_to_DISO71img Multiple Sclerosis C0026769
DISO_to_ANAT70img Brain C0006104
DISO_to_ANAT70img Oligodendroglia C0028944
DISO_to_ANAT59img Oligodendrocyte C0028944
DISO_to_ANAT45img Axon C0004461
DISO_to_ANAT43img Axon C0004461
DISO_to_ANAT38img Central Nervous System C0927232
DISO_to_PHYS38img Nerve Regeneration C0027756
DISO_to_PHYS35img Nerve Regeneration C0027756
DISO_to_CHEM33img Biscyclohexanone Oxaldihydrazone C0010460
DISO_to_CHEM33img Cuprizone C0010460
DISO_to_DISO32img Peripheral Nervous System Diseases C0031117
DISO_to_DISO31img Brain Diseases C0006111
DISO_to_ANAT30img Central Nervous System C0927232
Genes (277)

Species:
human : 277
Page Size
Current 25
  Page 1 of 12
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC100507436100507436
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanCD24100133941CD24 molecule
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanNCF1653361neutrophil cytosolic factor 1
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanNOS2P1645740nitric oxide synthase 2 pseudogene 1
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanMIR212406994microRNA 212
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanC10orf27219793
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanNOS2P2201288nitric oxide synthase 2 pseudogene 2
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanIL23R149233interleukin 23 receptor
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanADAMTS14140766ADAM metallopeptidase with thrombospondin type 1 motif, 14
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanEXOSC6118460exosome component 6
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanOLIG1116448oligodendrocyte transcription factor 1
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanKCNH790134potassium voltage-gated channel, subfamily H (eag-related), member 7
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanLINGO184894leucine rich repeat and Ig domain containing 1
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanHAVCR284868hepatitis A virus cellular receptor 2
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanACSBG281616acyl-CoA synthetase bubblegum family member 2
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanNOD264127nucleotide-binding oligomerization domain containing 2
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanPRX57716periaxin
img OMIM, Score=774, UMLKSK CUI: C0011303
HumanGJC257165gap junction protein, gamma 2, 47kDa
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanRTN457142reticulon 4
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanBTNL256244butyrophilin-like 2 (MHC class II associated)
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanTNFRSF1955504tumor necrosis factor receptor superfamily, member 19
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanXAF154739XIAP associated factor 1
INFERRED, Score=800, UMLKSK CUI: C0011303
HumanTLR954106toll-like receptor 9
INFERRED, Score=800, UMLKSK CUI: C0011303
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0011303Demyelinating Diseases0self