Human | KRT20 | 54474 | keratin 20 | CK20 is a sensitive and specific marker for Crooke's cells in the anterior pituitary and cytoskeletal changes that occur in corticotrophs in response to hypercortisolism |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | plasma ghrelin levels are decreased under endogenously or exogenously induced hypercortisolism, making ghrelin an unlikely candidate for causing the changes in energy balance or body composition characteristic of Cushing's disease ghrelin-induced growth hormone secretion was severely blunted in patients with active Cushing's syndrome, in addition to a remarkable hyper-response in ACTH and cortisol secretion |
Human | PDE11A | 50940 | phosphodiesterase 11A | Manifestations of Cushing syndrome may be mild |
Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker P-selectin or the number of circulating platelet-leucocyte aggregates |
Human | RET | 5979 | ret proto-oncogene | |
Human | PRKAR1A | 5573 | protein kinase, cAMP-dependent, regulatory, type I, alpha | germline and somatic mutations of the PRKAR1A gene in Cushing's syndrome caused by sporadic primary pigmented nodular adrenocortical disease Manifestations of Cushing syndrome may be mild |
Human | POMC | 5443 | proopiomelanocortin | ghrelin-induced growth hormone secretion was severely blunted in patients with active Cushing's syndrome, in addition to a remarkable hyper-response in ACTH and cortisol secretion |
Human | LHCGR | 3973 | luteinizing hormone/choriogonadotropin receptor | LH-responsive Cushing's syndrome, associated with bilateral adrenal hyperplasia, may result from aberrant (or possibly increased) adrenal LH receptor expression |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Cushing's syndrome patients have markedly elevated levels of the proinflammatory cytokine IL-18 |
Human | IL8 | 3576 | interleukin 8 | Cushing's syndrome patients have markedly elevated levels of the proinflammatory cytokine IL-8 |
Human | IL1RN | 3557 | interleukin 1 receptor antagonist | serum interleukin-1 receptor antagonist was strongly associated with regional fat distribution, and especially truncal fat mass, both at baseline and during treatment in Cushing's syndrome |
Human | HSD11B2 | 3291 | hydroxysteroid (11-beta) dehydrogenase 2 | Nonfunctioning adenomas and those causing preclinical and overt Cushing's syndrome may represent a continuum with clinical manifestations depending mainly on tumor size and HSD11B2 expression levels |
Human | HSD11B1 | 3290 | hydroxysteroid (11-beta) dehydrogenase 1 | the lack of increase of 11beta-HSD1 expression in Cushing's syndrome could suggest downregulation of the enzyme as a result of long-term overstimulatio Data suggest that humoral factors related to metabolic syndrome synergistically enhance hepatic expression of 11beta-hydroxysteroid dehydrogenase type 1 and cause Cushing state in the liver by increasing the intracellular glucocorticoid level |
Human | NR3C1 | 2908 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | cases of Cushing's syndrome with putative glucocorticoid receptor dysfunction exist, and we report one such likely case |
Human | GNAS | 2778 | GNAS complex locus | |
Human | GIPR | 2696 | gastric inhibitory polypeptide receptor | Mutation in promoter region of gip receptor gene are unlikely to underlie GIP-dependent Cushing syndrome |
Human | GH1 | 2688 | growth hormone 1 | ghrelin-induced growth hormone secretion was severely blunted in patients with active Cushing's syndrome, in addition to a remarkable hyper-response in ACTH and cortisol secretion |
Human | DUSP2 | 1844 | dual specificity phosphatase 2 | Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker PAC-1 or the number of circulating platelet-leucocyte aggregates |
Human | CD63 | 967 | CD63 molecule | Induction of hypercortisolism in healthy volunteers was associated with a trend toward higher expression of glycoprotein 53 on the platelet surface |