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Details
Link-It Detail - Disease - Cushing Syndrome
Debug Stats
  • ### Total Build Time: 316 ms 41.902 KB
  • CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 330 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 701 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 564 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 1.522 KB
  • CONCEPT_RELATIONSHIPS gt=253 ms Completed: 253 ms rowSize= 14.186 KB
  • CONCEPT_GENES gt=34 ms Completed: 34 ms rowSize= 23.268 KB
  • CONCEPT_XREFS gt=12 ms Completed: 12 ms rowSize= 1.150 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Cushing Syndrome C0010481
Definition (1)
A condition in which there is too much cortisol (a hormone made by the outer layer of the adrenal gland) in the body. Cushing syndrome may be caused by taking too many steroid drugs or by certain types of tumors. Tumors that make adrenocorticotropic hormone (ACTH) cause the adrenal gland to make too much cortisol. Symptoms of Cushing syndrome include a round face, thin arms and legs, severe fatigue and muscle weakness, high blood pressure, high blood sugar, purple or pink stretch marks on the skin, and weight gain, especially in the abdomen.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Adrenocortical Hyperfunction C0001622
Ancestral Roots
RootRoot Plus OneDepthParent
img Endocrine System Diseases C0014130img Adrenal Gland Diseases C00016214img Adrenocortical Hyperfunction C0001622
Relationships (118)

Relation Types:
diso_​to_​anat : 8
diso_​to_​chem : 54
diso_​to_​diso : 54
diso_​to_​phen : 2


Relationships:
none : 52
classifies : 1
disease_​has_​associated_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 2
mapped_​to : 17
may_​be_​associated_​disease_​of_​disease : 1
may_​diagnose : 36
may_​treat : 5
related_​to : 3
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO179img Complication Aspects C1171258
DISO_to_ANAT133img In Blood C0005768
DISO_to_DISO125img Complication Aspects C1171258
DISO_to_ANAT99img In Blood C0005768
DISO_to_CHEM88img Hydrocortisone C0020268
DISO_to_DISO87img Adenoma C0001430
DISO_to_DISO80img Pituitary Neoplasms C0032019
DISO_to_CHEM67img Adrenocorticotropic Hormone C0001655
DISO_to_CHEM66img Adrenocorticotropic Hormone C0001655
DISO_to_CHEM63img Hydrocortisone C0020268
DISO_to_DISO62img Adrenal Gland Neoplasms C0001624
DISO_to_DISO57img ACTH Syndrome, Ectopic C0001231
DISO_to_DISO56img chemically induced C0007994
DISO_to_DISO51img Adrenal Cortex Neoplasms C0001618
DISO_to_DISO51img chemically induced C0007994
DISO_to_CHEM50img GLUCOCORTICOIDS C0017710
DISO_to_DISO47img Adenoma C0001430
DISO_to_DISO45img Adrenal Gland Neoplasms C0001624
DISO_to_CHEM41img GLUCOCORTICOIDS C0017710
DISO_to_CHEM41img Glucocorticoids C0017710
DISO_to_ANAT37img Saliva C0036087
DISO_to_PHEN36img genetic aspects C0017399
DISO_to_DISO34img Adrenal Cortex Neoplasms C0001618
DISO_to_DISO32img Adrenal Cortical Adenoma C0206667
DISO_to_ANAT31img Adrenal Glands C0001625
Genes (19)

Species:
human : 19
SpeciesGeneGeneIdGene NameEvidence
HumanKRT2054474keratin 20
img GENERIF, Score=1000, Pubmed Id: 17525485, UMLKSK CUI: C0010481
HumanGHRL51738ghrelin/obestatin prepropeptide
img GENERIF, Score=827, Pubmed Id: 15248830, UMLKSK CUI: C0010481
img GENERIF, Score=901, Pubmed Id: 12566947, UMLKSK CUI: C0010481
HumanPDE11A50940phosphodiesterase 11A
img OMIM, Score=1000, UMLKSK CUI: C0010481
img OMIM, Score=1000, UMLKSK CUI: C0010481
HumanSELP6403selectin P (granule membrane protein 140kDa, antigen CD62)
img GENERIF, Score=1000, Pubmed Id: 18600034, UMLKSK CUI: C0010481
HumanRET5979ret proto-oncogene
img OMIM, Score=1000, UMLKSK CUI: C0010481
HumanPRKAR1A5573protein kinase, cAMP-dependent, regulatory, type I, alpha
img OMIM, Score=1000, UMLKSK CUI: C0010481
img GENERIF, Score=1000, Pubmed Id: 12213893, UMLKSK CUI: C0010481
img OMIM, Score=1000, UMLKSK CUI: C0010481
HumanPOMC5443proopiomelanocortin
img GENERIF, Score=901, Pubmed Id: 12566947, UMLKSK CUI: C0010481
HumanLHCGR3973luteinizing hormone/choriogonadotropin receptor
img GENERIF, Score=861, Pubmed Id: 12519858, UMLKSK CUI: C0010481
HumanIL183606interleukin 18 (interferon-gamma-inducing factor)
img GENERIF, Score=734, Pubmed Id: 11888846, UMLKSK CUI: C0010481
HumanIL83576interleukin 8
img GENERIF, Score=734, Pubmed Id: 11888846, UMLKSK CUI: C0010481
HumanIL1RN3557interleukin 1 receptor antagonist
img GENERIF, Score=1000, Pubmed Id: 12679428, UMLKSK CUI: C0010481
HumanHSD11B23291hydroxysteroid (11-beta) dehydrogenase 2
img GENERIF, Score=901, Pubmed Id: 12574226, UMLKSK CUI: C0010481
HumanHSD11B13290hydroxysteroid (11-beta) dehydrogenase 1
img GENERIF, Score=660, Pubmed Id: 18313835, UMLKSK CUI: C0010481
img GENERIF, Score=1000, Pubmed Id: 16914598, UMLKSK CUI: C0010481
HumanNR3C12908nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
img GENERIF, Score=1000, Pubmed Id: 18398271, UMLKSK CUI: C0010481
HumanGNAS2778GNAS complex locus
img OMIM, Score=1000, UMLKSK CUI: C0010481
HumanGIPR2696gastric inhibitory polypeptide receptor
img GENERIF, Score=861, Pubmed Id: 12530694, UMLKSK CUI: C0010481
HumanGH12688growth hormone 1
img GENERIF, Score=901, Pubmed Id: 12566947, UMLKSK CUI: C0010481
HumanDUSP21844dual specificity phosphatase 2
img GENERIF, Score=1000, Pubmed Id: 18600034, UMLKSK CUI: C0010481
HumanCD63967CD63 molecule
img GENERIF, Score=1000, Pubmed Id: 18600034, UMLKSK CUI: C0010481
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0010481Cushing Syndrome0self