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Details
Link-It Detail - Disease - Crohn Disease
Debug Stats
  • ### Total Build Time: 349 ms 57.810 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 324 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 515 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 563 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=4 ms Completed: 4 ms rowSize= 1.524 KB
  • CONCEPT_RELATIONSHIPS gt=296 ms Completed: 296 ms rowSize= 16.771 KB
  • CONCEPT_GENES gt=40 ms Completed: 40 ms rowSize= 36.778 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.147 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Crohn Disease C0010346
Definition (1)
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Inflammatory Bowel Diseases C0021390
Ancestral Roots
RootRoot Plus OneDepthParent
img Digestive System Diseases C0012242img Gastrointestinal Diseases C00171785img Inflammatory Bowel Diseases C0021390
Relationships (270)

Relation Types:
diso_​to_​anat : 24
diso_​to_​chem : 97
diso_​to_​diso : 116
diso_​to_​gene : 12
diso_​to_​phen : 4
diso_​to_​phys : 17


Relationships:
none : 186
allele_​not_​associated_​with_​disease : 1
associated_​with : 8
clinically_​similar : 1
disease_​has_​associated_​disease : 1
gene_​associated_​with_​disease : 8
gene_​product_​malfunction_​associated_​with_​disease : 2
inheritance_​type_​of : 1
is_​associated_​anatomic_​site_​of : 2
isa : 7
manifestation_​of : 14
mapped_​to : 2
may_​be_​associated_​disease_​of_​disease : 1
may_​treat : 30
related_​to : 4
use : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 11
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO1220img Complication Aspects C1171258
DISO_to_DISO964img Complication Aspects C1171258
DISO_to_DISO958img Colitis, Ulcerative C0009324
DISO_to_PHEN738img genetic aspects C0017399
DISO_to_DISO651img Colitis, Ulcerative C0009324
DISO_to_CHEM629img Antibodies, Monoclonal C0003250
DISO_to_PHEN499img genetic aspects C0017399
DISO_to_CHEM452img Antibodies, Monoclonal C0003250
DISO_to_CHEM421img Anti-Inflammatory Agents C0003209
DISO_to_CHEM290img 84-85 GASTROINTESTINAL DRUGS C0017173
DISO_to_CHEM266img Immunosuppressive Agents C0021081
DISO_to_ANAT241img In Blood C0005768
DISO_to_CHEM230img Tumor Necrosis Factor-alpha C1456820
DISO_to_CHEM217img 84-85 GASTROINTESTINAL DRUGS C0017173
DISO_to_CHEM192img Intracellular Signaling Peptides and Proteins C1449791
DISO_to_CHEM164img CARD15 Protein C1720989
DISO_to_CHEM164img Nod2 Signaling Adaptor Protein C1720989
DISO_to_CHEM163img Immunosuppressive Agents C0021081
DISO_to_PHYS155img GENET PREDISPOSITION C0314657
DISO_to_ANAT154img In Blood C0005768
DISO_to_ANAT151img Intestine, Small C0021852
DISO_to_ANAT149img Intestinal Mucosa C0021839
DISO_to_CHEM132img Tumor Necrosis Factor-alpha C1456820
DISO_to_GENE118img Polymorphism, Single Nucleotide C0752046
DISO_to_ANAT114img Ileum C0020885
Genes (231)

Species:
human : 228
mouse : 3
Page Size
Current 25
  Page 1 of 10
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseVCAM17412vascular cell adhesion molecule 1
img NCI, Score=801, Pubmed Id: 11729122, UMLKSK CUI: C0010346
img NCI, Score=801, Pubmed Id: 11729122, UMLKSK CUI: C0010346
MouseTNFSF47292tumor necrosis factor (ligand) superfamily, member 4
img NCI, Score=801, Pubmed Id: 12631559, UMLKSK CUI: C0010346
MouseCDH21000cadherin 2, type 1, N-cadherin (neuronal)
img NCI, Score=801, Pubmed Id: 7502046, UMLKSK CUI: C0010346
HumanMUC5B727897mucin 5B, oligomeric mucus/gel-forming
img NCI, Score=801, Pubmed Id: 10028446, UMLKSK CUI: C0010346
HumanIRGM345611immunity-related GTPase family, M
img GENERIF, Score=1000, Pubmed Id: 17921695, UMLKSK CUI: C0010346
img GENERIF, Score=901, Pubmed Id: 18580884, UMLKSK CUI: C0010346
img GENERIF, Score=1000, Pubmed Id: 17554261, UMLKSK CUI: C0010346
HumanIBD9317669inflammatory bowel disease 9
img OMIM, Score=1000, UMLKSK CUI: C0010346
HumanCCNY219771cyclin Y
img GENERIF, Score=1000, Pubmed Id: 18438405, UMLKSK CUI: C0010346
HumanPSORS1C1170679psoriasis susceptibility 1 candidate 1
img NCI, Score=801, Pubmed Id: 15301859, UMLKSK CUI: C0010346
img GENERIF, Score=1000, Pubmed Id: 15301859, UMLKSK CUI: C0010346
HumanIBD8170595inflammatory bowel disease 8
img OMIM, Score=1000, UMLKSK CUI: C0010346
HumanNKX2-3159296
img GENERIF, Score=1000, Pubmed Id: 18438405, UMLKSK CUI: C0010346
HumanIL23R149233interleukin 23 receptor
Click here to display 16 evidence detail records.
HumanNLRP3114548NLR family, pyrin domain containing 3
img GENERIF, Score=1000, Pubmed Id: 19098911, UMLKSK CUI: C0010346
img GENERIF, Score=1000, Pubmed Id: 19001869, UMLKSK CUI: C0010346
HumanREG483998regenerating islet-derived family, member 4
img NCI, Score=801, Pubmed Id: 11311942, UMLKSK CUI: C0010346
img NCI, Score=801, Pubmed Id: 11311942, UMLKSK CUI: C0010346
img NCI, Score=801, Pubmed Id: 12819006, UMLKSK CUI: C0010346
HumanC13orf2380209
img GENERIF, Score=1000, Pubmed Id: 18246054, UMLKSK CUI: C0010346
HumanNOD264127nucleotide-binding oligomerization domain containing 2
Click here to display 102 evidence detail records.
HumanIL2159067interleukin 21
img GENERIF, Score=1000, Pubmed Id: 17712836, UMLKSK CUI: C0010346
img NCI, Score=801, Pubmed Id: 15765404, UMLKSK CUI: C0010346
HumanCXCL1658191chemokine (C-X-C motif) ligand 16
img GENERIF, Score=1000, Pubmed Id: 18248772, UMLKSK CUI: C0010346
HumanMUC3B57876mucin 3B, cell surface associated
img NCI, Score=801, Pubmed Id: 10028446, UMLKSK CUI: C0010346
img NCI, Score=801, Pubmed Id: 11289722, UMLKSK CUI: C0010346
HumanIBD757042inflammatory bowel disease 7
img OMIM, Score=1000, UMLKSK CUI: C0010346
HumanBTNL256244butyrophilin-like 2 (MHC class II associated)
img GENERIF, Score=1000, Pubmed Id: 17610417, UMLKSK CUI: C0010346
img GENERIF, Score=1000, Pubmed Id: 17493147, UMLKSK CUI: C0010346
HumanITLN155600intelectin 1 (galactofuranose binding)
img GENERIF, Score=1000, Pubmed Id: 16386808, UMLKSK CUI: C0010346
HumanATG16L155054autophagy related 16-like 1 (S. cerevisiae)
Click here to display 10 evidence detail records.
HumanTLR954106toll-like receptor 9
img GENERIF, Score=1000, Pubmed Id: 17914947, UMLKSK CUI: C0010346
HumanGHRL51738ghrelin/obestatin prepropeptide
img GENERIF, Score=1000, Pubmed Id: 18425803, UMLKSK CUI: C0010346
HumanIL23A51561interleukin 23, alpha subunit p19
img GENERIF, Score=1000, Pubmed Id: 17007011, UMLKSK CUI: C0010346
img GENERIF, Score=1000, Pubmed Id: 18497880, UMLKSK CUI: C0010346
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0010346Crohn Disease0self