Mouse | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn;s disease in mice. CONCLUSIONS: These findings suggest that blocking ICAM-1 and VCAM-1 may have therapeutic benefit for the acute inflammatory component of Crohn;s disease. |
Mouse | TNFSF4 | 7292 | tumor necrosis factor (ligand) superfamily, member 4 | The OX40L blockade, especially in combination with the TNF-alpha blockade, may be a promising strategy for therapeutic intervention of Crohn;s disease. |
Mouse | CDH2 | 1000 | cadherin 2, type 1, N-cadherin (neuronal) | Analysis of adult chimeric mice revealed that expression of NCAD delta along the entire crypt-villus axis, but not in the villus epithelium alone, produced an inflammatory bowel disease resembling Crohn;s disease. |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Moreover, the expression levels of MUC3, MUC4, and MUC5B were significantly lower in both healthy and involved ileal mucosa of patients with Crohn;s disease compared to controls (p < or = 0.05). |
Human | IRGM | 345611 | immunity-related GTPase family, M | IRGM is significantly associated with Crohn disease This study has confirmed NCF4 and IRGM are risk factors for ileal Crohn's disease in New Zealand Caucasians Genetic evidence implicates IRGM defects in the early immune response in individuals with Crohn's disease |
Human | IBD9 | 317669 | inflammatory bowel disease 9 | 5-10% of patients have a first degree relative with IBD (Crohn or ulcerative colitis) |
Human | CCNY | 219771 | cyclin Y | Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis |
Human | PSORS1C1 | 170679 | psoriasis susceptibility 1 candidate 1 | Association of SEEK1 polymorphisms in Crohn;s disease. SEEK1 polymorphisms +39604, +39709, and +26680 are not associated with Crohn's disease in the Newfoundland population |
Human | IBD8 | 170595 | inflammatory bowel disease 8 | 5-10% of patients have a first degree relative with IBD (Crohn or ulcerative colitis) |
Human | NKX2-3 | 159296 | | Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis |
Human | IL23R | 149233 | interleukin 23 receptor | Click here to display 16 evidence detail records. |
Human | NLRP3 | 114548 | NLR family, pyrin domain containing 3 | These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis |
Human | REG4 | 83998 | regenerating islet-derived family, member 4 | Reg IV mRNA expression is significantly up-regulated by mucosal injury from active Crohn;s disease or ulcerative colitis. Reg IV mRNA expression is significantly up-regulated by mucosal injury from active Crohn;s disease or ulcerative colitis. An up-regulated expression of RELP was seen in epithelial cells of inflammatory mucosa in ulcerative colitis and Crohn;s disease, in regenerating epithelial borders of gastric ulcers, and in metaplastic epithelium in the antrum and the esophagus. |
Human | C13orf23 | 80209 | | Genomic regions have been identified demonstrating significant evidence for single nucleotide polymorphism linkage to Crohn's disease on chromosomes 16q12.1 and 13q13.3, and suggestive evidence for linkage to ulcerative colitis on chromosome 19p12 |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Click here to display 102 evidence detail records. |
Human | IL21 | 59067 | interleukin 21 | REVIEW:IL-21 is highly produced by activated CD4+ lymphocytes in the inflamed gut of patients with Crohn's disease, where it contributes to sustaining the ongoing Th1 inflammation Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn;s disease. |
Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | in Crohn's disease (CD), the CXCL16 p.Ala181Val polymorphism is not a disease susceptibility gene but associated with younger age at disease onset and higher frequency of ileal involvement |
Human | MUC3B | 57876 | mucin 3B, cell surface associated | Moreover, the expression levels of MUC3, MUC4, and MUC5B were significantly lower in both healthy and involved ileal mucosa of patients with Crohn;s disease compared to controls (p < or = 0.05). Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn;s disease. |
Human | IBD7 | 57042 | inflammatory bowel disease 7 | 5-10% of patients have a first degree relative with IBD (Crohn or ulcerative colitis) |
Human | BTNL2 | 56244 | butyrophilin-like 2 (MHC class II associated) | Does not contribute to susceptibility to Crohn's disease in Japan but is associated with Japanese ulcerative colitis because of strong linkage disequilibrium with HLA-DRB1*1502 a major effect of the BTNL2 rs2076530 (G --> A) SNP in Crohn's disease and tuberculosis was excluded; there was an association with susceptibility to leprosy (P=0.04), however, this is most likely due to linkage disequilibrium with HLA-DR |
Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease |
Human | ATG16L1 | 55054 | autophagy related 16-like 1 (S. cerevisiae) | Click here to display 10 evidence detail records. |
Human | TLR9 | 54106 | toll-like receptor 9 | TLR9 variants were not major risk factors for Crohn's disease in New Zealand population, but may associations with disease worldwide |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | The dysregulation of reactivity of T cells induced by ghrelin is associated with the pathogenesis of Crohn's disease |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | This review summarizes information on the expression and role of IL-12 both in patients with Crohn's diease and experimental models of colitis, thus emphasizing differences between IL-12 and IL-23 activity on the development of intestinal inflammation intestinal macrophages expressing CD14 contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis |