Human | HAMP | 57817 | hepcidin antimicrobial peptide | hepcidin plays a major, causative role in the anemia observed in a subgroup of patients with hepatic adenomas, and may be important in the pathogenesis of the anemia of chronic disease in general In anemia of chronic disease, hepcidin mRNA levels were significantly correlated to serum IL-6 concentrations, and increased monocyte hepcidin mRNA levels were associated with decreased expression of iron retention |
Human | TNF | 7124 | tumor necrosis factor | TNF-alpha-mediated apoptotic depletion of BM erythroid cells may account for Anemia of chronic disease in rheumatoid arthritis |
Human | TGFBR1 | 7046 | transforming growth factor, beta receptor 1 | TGFbeta1/ALK5 may alleviate scarring in chronic fibrotic disease |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | a novel role for the plasminogen activation system in the regulation of fibroblast apoptosis and a potential role of TGF-beta1/PAI-1 in promoting (myo)fibroblast survival in chronic fibrotic disorders |
Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | in the investigated Finnish pedigree with hereditary pancreatitis, the PRSS1 mutation R122H is linked with chronic disease; although the SPINK1 mutation (N34S) was also observed in two individuals, it was not linked with the disease |
Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion |
Human | SAA@ | 6287 | serum amyloid A1 cluster | Serum amyloid A appears to be important mediator of inflammatory process, possibly contributing to pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases |
Human | PRSS1 | 5644 | protease, serine, 1 (trypsin 1) | in the investigated Finnish pedigree with hereditary pancreatitis, the PRSS1 mutation R122H is linked with chronic disease; although the SPINK1 mutation (N34S) was also observed in two individuals, it was not linked with the disease |
Human | MT1A | 4489 | metallothionein 1A | metallothionein measured in renal specimens from cadaver kidneys was restricted to tubular cells with no differences between controls and patients with death due to chronic diseases |
Human | LAMA3 | 3909 | laminin, alpha 3 | An N-termninal deletion of the LAMA3 isoform leads to the chronic ganulation tissue disorder laryngo-onycho-cutaneous syndrome |
Human | JAK2 | 3717 | Janus kinase 2 | This is the first report on the JAK2 gene mutation in AML, and the data indicated that the JAK2 gene mutation may not only contribute to the development of chronic myeloid disorders, but also to some AMLs |
Human | IL8 | 3576 | interleukin 8 | Serum amyloid A appears to be important mediator of inflammatory process, possibly contributing to pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | review of roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses; the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression |
Human | IFNG | 3458 | interferon, gamma | gamma interferon implicated in the pathogenesis of the anemia of chronic disease may exert its effects at least in part through modulation of oxidative stress |
Human | HEXB | 3074 | hexosaminidase B (beta polypeptide) | novel c.1556A>G transition in exon 12 of the HEXB gene associated with chronic Sandhoff's disease |
Human | F2 | 2147 | coagulation factor II (thrombin) | Patients with a previous history of acute coronary artery disease showed earlier, faster and higher thrombin generation than patients with stable chronic disease |
Human | CFTR | 1080 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | The significantly higher frequency of CFTR mutations among patients with chronic pulmonary disease compared with unaffected controls suggests that these mutations may increase risk for disease |
Human | BPI | 671 | bactericidal/permeability-increasing protein | The present study does not give evidence for the contribution of the BPI gene to the genetic background of chronic periodontal disease |