Genes (95)
Species: human : 92 mouse : 3 | |
Mouse | LECT1 | 11061 | leukocyte cell derived chemotaxin 1 | The level of ChM-I transcripts in the lower-grade chondrosarcomas was substantially reduced to several hundreds or less in the lower-grade chondrosarcomas, compared with that of articular cartilage or other benign cartilage tumours. Here, we demonstrated that the level of ChM-I transcripts was substantially reduced to 100 or even less in the lower-grade chondrosarcomas, in articular cartilage or other benign cartilage tumors. | Mouse | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | Expression of the CCN family members NOV, CTGF, CYR61, and WISP-1 was examined in 15 chondrosarcomas of various grades and in three enchondromas. | Mouse | NFATC2 | 4773 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas. | Human | CD24 | 100133941 | CD24 molecule | CD24 expression was upregulated in chordoma, while it was absent in chondrosarcoma | Human | CSAG2 | 728461 | CSAG family, member 2 | CSAGE and TRAG-3 are expressed in chondrosarcoma, melanoma, and cartilage and testis, but not in other normal tissues. | Human | TMEM30B | 161291 | transmembrane protein 30B | Human CDC50A mRNA was expressed in embryonic stem (ES) cells, placenta, brain and chondrosarcoma, while CDC50B mRNA was expressed in pancreatic islet, kidney, prostate as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer. | Human | CSAG1 | 158511 | chondrosarcoma associated gene 1 | CSAGE and TRAG-3 are expressed in chondrosarcoma, melanoma, and cartilage and testis, but not in other normal tissues. Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma. | Human | FMNL2 | 114793 | formin-like 2 | FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma, and FMNL3 mRNA in gastric cancer. | Human | ADAMTS9 | 56999 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. | Human | DACT1 | 51339 | dishevelled-binding antagonist of beta-catenin 1 | DAPPER1 mRNA was expressed in amnion, fetal brain, eye, heart, adult brain medulla, gastric cancer (signet ring cell features), RER+ colon tumor, acute lymphoblastic leukemia, germ cell tumor, chondrosarcoma, and parathyroid tumor. | Human | CHST11 | 50515 | carbohydrate (chondroitin 4) sulfotransferase 11 | Chondroitin 4-sulfotransferase, which transfers sulfate from 3;-phosphoadenosine 5;-phosphosulfate to position 4 of N-acetylgalactosamine in chondroitin, was purified 1900-fold to apparent homogeneity with 6.1% yield from the serum-free culture medium of rat chondrosarcoma cells by affinity chromatography on heparin-Sepharose CL-6B, Matrex gel red A-agarose, 3;,5;-ADP-agarose, and the second heparin-Sepharose CL-6B. | Human | HPGDS | 27306 | hematopoietic prostaglandin D synthase | INFERRED, Score=800, UMLKSK CUI: C0008479 | Human | SRGAP2 | 23380 | SLIT-ROBO Rho GTPase activating protein 2 | FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. | Human | LECT1 | 11061 | leukocyte cell derived chemotaxin 1 | The local administration of recombinant human ChM-I almost completely blocked tumour angiogenesis and growth in the human chondrosarcoma xenografts in mice. We first identified a genomic DNA fragment which encoded the N-terminus of the ChM-I precursor, and then isolated human ChM-I cDNA from chondrosarcoma tissue by PCR. These include BRI(2), which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I (ChM-I), related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress syndrome (RDS). Taking advantage of ectopic bone formation and xenograft tumour model by human chondrosarcoma cell line OUMS-27, we examined how ChM-I is involved in switching of angiogenesis in cartilage. We investigated the expression of the Chondromodulin-I (ChM-I) gene, a putative tumor suppressor gene in cartilaginous tumors, by quantitative RT-PCR in 15 chondrosarcomas (CSs). | Human | TOB1 | 10140 | transducer of ERBB2, 1 | Tob1 expression was also detected at a decreased level in isolated chondrocytes and in the chondrosarcoma cell line HCS-2/8. | Human | SRGAP3 | 9901 | SLIT-ROBO Rho GTPase activating protein 3 | FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. | Human | ADAMTS4 | 9507 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Catabolism by aggrecanase activities induced in rat chondrosarcoma cells, porcine chondrocytes, and by human recombinant ADAMTS4 showed a gradually decreasing catabolism of progressively shortened, N-terminal deletion mutants of the substrate rAgg1mut. To examine the mode of activation of ADAMTS4, a human chondrosarcoma cell line, JJ012, has been stably transfected with the full-length c-DNA for human ADAMTS4. In transfected human chondrosarcoma cells, this process is not autoproteolytic because the same products form with an inactive mutant of ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin-like motif 4) and truncation is completely blocked by tissue inhibitor of metalloproteinase-1. MATERIALS AND METHODS: In 28 chondrosarcoma cases, immunostaining was performed using antibodies against MMP 2, 3, 7, 9, 13, ADAMTS 4, 5 and TIMP 1, 2, 3. | Human | ITM2B | 9445 | integral membrane protein 2B | These include BRI(2), which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I (ChM-I), related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress syndrome (RDS). | Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant chondrogenic tumors, we examined 89 cases of malignant chondrogenic tumors comprising 17 conventional chondrosarcomas, 33 mesenchymal chondrosarcomas, and 39 clear cell chondrosarcomas. | Human | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | Findings indicate that the WISP1v splicing variant plays a critical role in chondrocyte differentiation, whereas the HCS-2/8-specific splicing variant WISP1vx may be associated with the transformed phenotypes of chondrosarcomas | Human | ADAM15 | 8751 | ADAM metallopeptidase domain 15 | The extension of the analysis to chondrosarcomas showed a strong up-regulation of MDC15 mRNA in these malignant transformed cells. | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | RESULTS: RT-PCR analysis indicated that RANKL mRNA was present in all chondroblastoma specimens and normal cancellous bone samples, but not in normal articular cartilage and chondrosarcoma tissues. | Human | PPFIBP1 | 8496 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | CONCLUSIONS.: In the current study the authors identified genomic regions and new candidate genes (RPS6, CDK4, and PPFIBP1) that were associated with tumor progression and prognosis in patients with high-grade chondrosarcomas. | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | Expression of HMGA2 could be assessed by RT-PCR in 8 chondromas and 13 chondrosarcomas. | Human | NR4A3 | 8013 | nuclear receptor subfamily 4, group A, member 3 | The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. These results suggest that EWS/TEC interacts at least in part with the same transcriptional coactivators as the native TEC receptor, and that these coactivators may be involved in the tumoral process leading to human chondrosarcoma tumors. The NOR-1 subfamily (NR4), composed also of Nurr1 and Nurr77, has been implicated in cell proliferation, differentiation, apoptosis, chondrosarcomas, inflammation, and atherogenesis. |
|