Human | TUBB1 | 81027 | tubulin, beta 1 class VI | The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men |
Human | HSPB8 | 26353 | heat shock 22kDa protein 8 | HspB8 might play important role in regulating Abeta aggregation and, therefore, development of classic senile plaques in Alzheimer's disease and cerebral amyloid angiopathy in hereditary cerebral hemorrhage with amyloidosis of Dutch type |
Human | KIF1B | 23095 | kinesin family member 1B | |
Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | |
Human | SDHD | 6392 | succinate dehydrogenase complex, subunit D, integral membrane protein | |
Human | SDHB | 6390 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | |
Human | S100B | 6285 | S100 calcium binding protein B | Increased plasma S100B level is found following acute spontaneous intracerebral hemorrhage, in association with a worse early and late evolution, and closely related to initial hematoma volume |
Human | RET | 5979 | ret proto-oncogene | |
Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | OPG-1181C/C genotype associates with risk for first-ever intracerebral hemorrhage but not with risk of ischemic stroke |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The incidences of both homozygous and heterozygous MTHFR gene mutations in cerebral ischemia (26 and 43%) and in cerebral hemorrhage (25 and 60%) were significantly higher than those in the controls (8 and 25%) |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | vascular MMP-9 expression may play a role in the pathogenesis of spontaneous intracerebral hemorrhage--REVIEW |
Human | JAK2 | 3717 | Janus kinase 2 | |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL-6 genotype did not associate with risk for first ever intracerebral hemorrhage or ischemic stroke |
Human | IL1RN | 3557 | interleukin 1 receptor antagonist | IL-1ra attenuated brain edema formation following intracerebral hemorrhage, perhaps by reduction of thrombin-induced brain inflammation |
Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | study the changes of plasma insulin-like growth factor -1 (IGF-1) and IGF binding protein 3 (IGFBP3) in patients with acute cerebral infarct (ACI) and acute cerebral hemorrhage (ACH) |
Human | HCRT | 3060 | hypocretin (orexin) neuropeptide precursor | orexin-A/hypocretin-1 may therefore play an important role in the various physiological responses including sleep, feeding, and the overall metabolism in intracerebral hemorrhage patients |
Human | GDNF | 2668 | glial cell derived neurotrophic factor | |
Human | F7 | 2155 | coagulation factor VII (serum prothrombin conversion accelerator) | Investigated polymorphisms in the FVII gene are not significantly associated with increased risk for primary intracerebral hemorrhage |
Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | No evidence of an association between factor V Leiden mutation and ischemic stroke or intracerebral hemorrhage |
Human | EPOR | 2057 | erythropoietin receptor | |
Human | ENG | 2022 | endoglin | |
Human | ACE | 1636 | angiotensin I converting enzyme | ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for spontaneous intracerebral hemorrhage, and not for small vessel disease stroke, in a Polish population |
Human | CST3 | 1471 | cystatin C | Accumulating data suggest involvement of cystatin C in the pathogenic processes leading to amyloid deposition in cerebral vasculature and most significantly to cerebral hemorrhage in patients with cerebral amyloid angiopathy {REVIEW} |
Human | ABCC6 | 368 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | |
Human | APP | 351 | amyloid beta (A4) precursor protein | A novel mutation (Leu705Val) within the Abeta sequence of a AbetaPP is reported in a family with autosomal dominant, recurrent intracerebral hemorrhages beginning in the sixth decade of life A novel mutation (L705V) within the Abeta sequence of AbetaPP in a family with autosomal dominant, recurrent intracerebral hemorrhages |