Debug Stats | ### Total Build Time: 34 ms 41.718 KB CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 326 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 238 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 989 bytesCONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 559 bytesCONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 2.771 KBCONCEPT_RELATIONSHIPS gt=9 ms Completed: 9 ms rowSize= 14.249 KBCONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 21.277 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.148 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
|
Genes (17)
Species: human : 17 | |
Human | MYLK3 | 91807 | myosin light chain kinase 3 | Our findings suggest an important role of Rac, Rho/Rho-kinase, and MLCK in controlling myosin activity in Walker carcinosarcoma cells and show that an appropriate level of RhoA, Rac, and Rho-kinase activity is required to regulate cell polarity and migration. | Human | TUBA1C | 84790 | tubulin, alpha 1c | The anti-vascular effects of the tubulin binding agent, disodium combretastatin A-4 3-O-phosphate (CA-4-P), have been investigated in the rat P22 carcinosarcoma by measurements of radiolabelled iodoantipyrine uptake and dynamic contrast-enhanced MRI. | Human | XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | The absence of coding sequence mutations in primary carcinosarcomas suggests that XRCC2 defects are unlikely to play a significant role in carcinosarcoma tumorigenesis. | Human | VTNR | 7449 | | Endothelial cell damage by Walker carcinosarcoma cells is dependent on vitronectin receptor-mediated tumor cell adhesion. | Human | TP53 | 7157 | tumor protein p53 | Defective DNA mismatch repair and TP53 defects are common early events in carcinosarcoma tumorigenesis | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | LOH for NM23 was detected in both components in one carcinosarcoma, whereas LOH for INT-2 was detected in both components in one metaplastic carcinoma. | Human | MSN | 4478 | moesin | Ezrin/moesin in motile Walker 256 carcinosarcoma cells: signal-dependent relocalization and role in migration. | Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | Data provide evidence of a role for MDM2 and CDK4 in the pathogenesis of carcinosarcoma | Human | GLS | 2744 | glutaminase | The influence of modified antineoplaston AS2-1 (with altered ratio of L-phenylalanine and L-glutamine derivatives, ;Deglutam;) on the activity of glutamine synthetase, glutaminase isoforms in the carcinosarcoma SM-1, tumor weight, per cent of the inhibition of tumor growth and blood impact index was investigated in rats with carcinosarcoma SM-1. | Human | FGFR2 | 2263 | fibroblast growth factor receptor 2 | In this study, the expression of mRNAs encoding KGF, KGFR, and FGFR-2 in endometrial adenocarcinoma and in carcinosarcoma tissues was examined and the expression of the same mRNAs was compared with cycling endometrium. CONCLUSIONS: To the authors knowledge, this study demonstrates for the first time the expression of KGF, KGFR, and FGFR-2 mRNAs in endometrial adenocarcinoma and in carcinosarcoma tissues. | Human | FGF7 | 2252 | fibroblast growth factor 7 | In this study, the expression of mRNAs encoding KGF, KGFR, and FGFR-2 in endometrial adenocarcinoma and in carcinosarcoma tissues was examined and the expression of the same mRNAs was compared with cycling endometrium. CONCLUSIONS: To the authors knowledge, this study demonstrates for the first time the expression of KGF, KGFR, and FGFR-2 mRNAs in endometrial adenocarcinoma and in carcinosarcoma tissues. RESULTS: The KGF mRNA expression was significantly lower in endometrial adenocarcinoma tissue compared with cycling endometrial tissues, whereas no difference was found between carcinosarcoma tissue and cycling endometrium. | Human | CPT2 | 1376 | carnitine palmitoyltransferase 2 | Carnitine palmitoyltransferase II activity is decreased in liver mitochondria of cachectic rats bearing the Walker 256 carcinosarcoma: effect of indomethacin treatment. | Human | CLDN3 | 1365 | claudin 3 | Claudin-3 and claudin-4 receptors are highly overexpressed in carcinosarcoma | Human | CLDN4 | 1364 | claudin 4 | Claudin-3 and claudin-4 receptors are highly overexpressed in carcinosarcoma | Human | BMP6 | 654 | bone morphogenetic protein 6 | In vitro effects of bone- and platelet-derived transforming growth factor-beta on the growth of Walker 256 carcinosarcoma cells. | Human | RHOA | 387 | ras homolog family member A | Our findings suggest an important role of Rac, Rho/Rho-kinase, and MLCK in controlling myosin activity in Walker carcinosarcoma cells and show that an appropriate level of RhoA, Rac, and Rho-kinase activity is required to regulate cell polarity and migration. | Human | ACTC1 | 70 | actin, alpha, cardiac muscle 1 | The immunohistochemical reactivity with CD31, factor VIII, and CD34 and lack of reactivity with smooth muscle actin, keratin, and estrogen receptor confirm the vascular nature of these lesions and exclude the differential diagnostic considerations of carcinosarcoma (MMMT), leiomyosarcoma, adenosarcoma, and hemangiopericytoma. |
|