Mouse | FETUB | 26998 | fetuin B | Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice. |
Mouse | TRIM32 | 22954 | tripartite motif containing 32 | Tripartite motif protein 32, Trim32, mRNA and protein expression was elevated in independently transformed and tumorigenic keratinocytes of a mouse epidermal carcinogenesis model, in ultraviolet B (UVB)-induced squamous cell carcinomas (SCC), and in approximately 20-25% of chemically induced mouse papillomas and human head and neck SCCs. |
Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Click here to display 4 evidence detail records. |
Mouse | HMGA2 | 8091 | high mobility group AT-hook 2 | Additionally, squamous carcinoma-like salivary tumors were observed in the AQP-5/HMGA2 transgenic mice, albeit at a low incidence. |
Mouse | TFPI2 | 7980 | tissue factor pathway inhibitor 2 | [Experimental investigation of effects of adenovirus transducted tissue factor pathway inhibitor-2 gene on growth of laryngeal squamous carcinoma] |
Mouse | XPC | 7508 | xeroderma pigmentosum, complementation group C | Click here to display 3 evidence detail records. |
Mouse | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Inhibition of beta-catenin/Tcf signaling by ectopic expression of dominant negative Tcf4 resulted in significant inhibition of growth in squamous cell carcinoma cells. |
Mouse | TCF4 | 6925 | transcription factor 4 | Inhibition of beta-catenin/Tcf signaling by ectopic expression of dominant negative Tcf4 resulted in significant inhibition of growth in squamous cell carcinoma cells. |
Mouse | ST14 | 6768 | suppression of tumorigenicity 14 (colon carcinoma) | Modest orthotopic overexpression of matriptase in the skin of transgenic mice caused spontaneous squamous cell carcinoma and dramatically potentiated carcinogen-induced tumor formation. |
Mouse | PVRL1 | 5818 | poliovirus receptor-related 1 (herpesvirus entry mediator C) | Because highly invasive cells may have decreased intercellular adhesion, we sought to determine if such cells might also have altered availability of cell surface nectin-1 to act as a herpes receptor.Experimental Design and RESULTS: A series of squamous cell carcinoma lines of increasing migratory and invasive potential, termed MG1-MG14, were selected by serial passages of murine SCC7 through Matrigel invasion chambers. |
Mouse | SMAD7 | 4092 | SMAD family member 7 | Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. |
Mouse | SMAD6 | 4091 | SMAD family member 6 | Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. |
Mouse | KRT13 | 3860 | keratin 13 | Recently, however, we were able to show that K13 is aberrantly but constitutively expressed without its normal type II partner K4 also in differentiating parts of 7,12-dimethylbenz(a)anthracene (DMBA/TPA) 12-O-tetradecanoylphorbol-13-acetate-induced squamous cell carcinomas of mouse back skin, whereas its likewise suprabasal expression in papillomas is variable (Nischt et al., Mol. |
Mouse | JUN | 3725 | jun proto-oncogene | These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers. |
Mouse | DNAJB1 | 3337 | DnaJ (Hsp40) homolog, subfamily B, member 1 | Click here to display 4 evidence detail records. |
Mouse | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | In epidermal carcinogenesis, HIF-1alpha, GLUT-1, PGK-1, and VEGF mRNAs were just detectable in early-stage hyperplasia, markedly increased in high-grade epidermal chest dysplasias, and further increased in invasive squamous carcinomas. |
Mouse | CXCL1 | 2919 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | We previously reported that chemokine Growth Regulated Oncogene 1 (Gro 1) is over-expressed in murine squamous cell carcinoma (SCC) with metastatic tumor progression. Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms. |
Mouse | FYN | 2534 | FYN oncogene related to SRC, FGR, YES | Furthermore, dominant negative Fyn decreases the ability of squamous carcinoma cells to invade through Matrigel in vitro and to form lung metastases following intravenous injection in nude mice. |
Mouse | ERCC6 | 2074 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | Click here to display 3 evidence detail records. |
Mouse | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | Uvomorulin (E-cadherin), a cell adhesion molecule, and Na+,K(+)-adenosine triphosphatase (ATPase), a marker protein of the basal-lateral cell membrane domains of polarized epithelial cells, were investigated in a group of mouse skin tumors induced by a two-stage chemical carcinogenesis protocol and in cell lines derived from mouse skin papillomas and squamous cell carcinomas (SCC). |
Mouse | CD81 | 975 | CD81 molecule | CD81 was undetectable in untreated epidermis and strongly expressed in all transgenic and wild-type squamous cell carcinomas. |
Mouse | CD80 | 941 | CD80 molecule | NRS1 is a murine squamous cell carcinoma that constitutively expresses the co-stimulatory molecule CD80 at a high level yet grows as a tumour in syngeneic C3H mice. |
Human | LOC100507436 | 100507436 | | Click here to display 3 evidence detail records. |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Click here to display 11 evidence detail records. |
Human | MAGED4 | 728239 | melanoma antigen family D, 4 | In addition, a high MAGE-D4 expression was more frequently seen in squamous cell carcinoma than in adenocarcinoma (p=0.008), and less frequently in well-differentiated tumors than in moderately to poorly differentiated tumors (p=0.036). |