Genes (387)
Species: human : 382 mouse : 5 | |
| Mouse | CADM1 | 23705 | cell adhesion molecule 1 | Expression of TSLC1 in a non-small-cell lung cancer (NSCLC) cell line A549 suppresses tumorigenicity in nude mice. A tumor suppressor gene, TSLC1/IGSF4, from chromosomal region 11q23 was identified in non-small cell lung cancer (NSCLC) by its tumor suppressor activity in nude mice. Furthermore, restoration of TSLC1 expression strongly suppressed the metastasis of a human non-small cell lung cancer cell line, A549, from the spleen to the liver in nude mice. | | Mouse | DLC1 | 10395 | deleted in liver cancer 1 | Furthermore, stable transfer of DLC-1 abolished tumorigenicity in nude mice of two cell lines, suggesting that DLC-1 plays a role in NSCLC by acting as a bona fide new tumor suppressor gene. | | Mouse | ADAM9 | 8754 | ADAM metallopeptidase domain 9 | These results suggest that ADAM9 overexpression enhances cell adhesion and invasion of non-small cell lung cancer cells via modulation of other adhesion molecules and changes in sensitivity to growth factors, thereby promoting metastatic capacity to the brain. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. | | Mouse | EIF3E | 3646 | eukaryotic translation initiation factor 3, subunit E | This study aimed to investigate the prognostic role of Int6 in a large series of stage I non-small cell lung cancers (NSCLC) patients with long-term follow-up.EXPERIMENTAL DESIGN: We determined the methylation status of Int6 DNA by methylation-specific PCR and the steady-state levels of Int6 RNA by quantitative real-time reverse transcription-PCR in 101 NSCLCs and matched normal lung tissues.RESULTS: In 27% of the tumors, Int6 RNA levels were reduced relative to normal tissue. | | Mouse | DUSP1 | 1843 | dual specificity phosphatase 1 | Overall, the results showed that inhibition of MKP1 expression contributes to a slow down in cell growth in mice and an increase of cisplatin-induced cell death in NSCLC. | | Human | CSAG2 | 728461 | CSAG family, member 2 | Expression of TRAG-3 antigen in non-small-cell lung carcinomas. Because TRAG-3 antigen is expressed in most melanomas and 54% of non-small cell lung carcinomas and HLA-A2.1-expressing individuals cover >50% in the population of China, we aim at identifying TRAG-3-encoded peptide presented by HLA-A2.1. CONCLUSIONS: Because TRAG-3 is a cancer/testis antigen expressed in most melanomas and half of non-small cell lung carcinomas, identification of the TRAG-3/HLA-A2.1 peptide ILLRDAGLV may facilitate peptide-based specific immunotherapy for various histological tumors. | | Human | MAGED4 | 728239 | melanoma antigen family D, 4 | CONCLUSIONS: MAGE-D4 plays some roles in tumor cells proliferation in NSCLC, but MAGE-D4 expression status did not provided a prognostic significance. RESULTS: We assessed MAGE-D4 expression in NSCLC tissues and was found to be up-regulated in tumor tissues compared with normal lung tissues (mean MAGE-D4/GAPDH values, 0.035 for tumor tissues and 0.009 for normal lung tissues; p=0.002). Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. The present study was conducted to assess the clinical significance of MAGE-D4 expression in non-small cell lung cancer (NSCLC). | | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. | | Human | SFTPA1 | 653509 | surfactant protein A1 | Click here to display 16 evidence detail records. | | Human | MALAT1 | 378938 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | Several of the identified genes (eIF4A1, thymosin beta4 and a novel transcript named MALAT-1) were demonstrated to be significantly associated with metastasis in NSCLC patients (n=70). MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. In our own work, we have identified several genes (e.g. thymosin beta-4, elF4A1), including a novel non-coding RNA (MALAT-1) to be expressed at significantly higher levels in stage-I and stage-II NSCLC primary tumours that subsequently metastasised. | | Human | SERINC2 | 347735 | serine incorporator 2 | Identification of TDE2 gene and its expression in non-small cell lung cancer. TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Using real-time quantitative PCR, we showed that TDE2 transcript levels were higher in NSCLC compared to nonmalignant samples. | | Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | METHODS: DC vaccines were generated from CD14+ precursors, pulsed with apoptotic bodies of an allogeneic NSCLC cell line that overexpressed Her2/neu, CEA, WT1, Mage2, and survivin. | | Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | However, 24-h exposure of a non-small cell lung carcinoma cell line, NCI H157, to 10 microM of N1,N;-bis(ethyl)norspermine results in approximately 5-fold induction of PAO mRNA and a >3-fold induction of PAO activity. | | Human | PRKCDBP | 112464 | protein kinase C, delta binding protein | In all, 79% of lung cancer cell lines were methylated and the frequency of hSRBC methylation was significantly higher in SCLC (100%) than in NSCLC (58%) cell lines. | | Human | MYLK3 | 91807 | myosin light chain kinase 3 | Conclusion: These findings are the first clinical evidence that expression of MLCK is correlated with disease recurrence and distant metastasis in NSCLC. In the present study, therefore, we examined the role of MLCK in the metastasis of non-small cell lung cancer (NSCLC) in a clinical setting. Increased expression of Myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer. | | Human | FATE1 | 89885 | fetal and adult testis expressed 1 | FATE/BJ-HCC-2 mRNA was detected in 66% (41 out of 62) in hepatocellular carcinoma (HCC) samples and 21% (three out of 14) in colon cancer samples, whereas the TPTE/BJ-HCC-5 mRNA was detected in 39% (24 out of 62) and 36% (five out of 14) in HCC and non-small lung cancer samples, respectively. | | Human | TUBA1C | 84790 | tubulin, alpha 1c | Docetaxel (Taxotere, Aventis Pharma), a semisynthetic taxane targeting the beta-subunit of tubulin, has broad spectrum anticancer activity including non-small cell lung cancer (NSCLC). In this study, the tubulin isotype diversity in MDA-MB-231, a human breast carcinoma cell line, and A549, a human non-small lung cancer cell line, is reported. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Paclitaxel, a member of the taxane family of antineoplastic agents that is used in the treatment of breast carcinoma, ovarian carcinoma, and non-small cell lung carcinoma, acts by the simultaneous promotion of tubulin assembly into microtubules and inhibition of microtubule disassembly. | | Human | MYO18B | 84700 | myosin XVIIIB | MYO18B expression was reduced in 88% (30/34) of NSCLC and 47% (8/17) of SCLC cell lines. Somatic MYO18B mutations were detected in 19% (14/75) of lung cancer cell lines and 13% (6/46) of primary lung cancers of both SCLC and NSCLC types. | | Human | AKT1S1 | 84335 | AKT1 substrate 1 (proline-rich) | We also discussed PRAS40 activity in other NSCLC cell lines. | | Human | DYNLRB1 | 83658 | dynein, light chain, roadblock-type 1 | Click here to display 5 evidence detail records. | | Human | NUF2 | 83540 | NUF2, NDC80 kinetochore complex component | Knockdown of either CDCA1 or KNTC2 expression with small interfering RNA significantly suppressed growth of NSCLC cells. We found cotransactivation of cell division associated 1 (CDCA1) and kinetochore associated 2 (KNTC2), members of the evolutionarily conserved centromere protein complex, in non-small cell lung carcinomas (NSCLC). Furthermore, inhibition of their binding by a cell-permeable peptide carrying the CDCA1-derived 19-amino-acid peptide (11R-CDCA1(398-416)) that correspond to the binding domain to KNTC2 effectively suppressed growth of NSCLC cells. | | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | MAGE-1 transcripts are also detectable in breast cancers, in non-small-cell lung carcinomas and in central nervous system tumors. MAGE-1, -2, -3/-6 and -4 genes were expressed, respectively, at the mRNA level in 6, 7, 20 and 7 of 53 lung cancers (50 non-small-cell lung cancers and 3 small-cell lung cancers) by the reverse transcription-polymerase chain reaction (RT-PCR) method. | | Human | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | The aim of this study is to evaluate the in vivo expression level of TDP1, as well as parallel repair pathway components XPF and MUS81, in primary NSCLC. | | Human | SNIP1 | 79753 | Smad nuclear interacting protein 1 | The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis. | | Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | Click here to display 5 evidence detail records. |
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