Genes (48)
Species: human : 48 | |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Mucinous bronchioloalveolar carcinoma (BAC) had a homogeneous pattern of mucin gene expression different from those of other types of lung adenocarcinoma, involving secreted mucins (MUC5AC, MUC5B, and MUC6) and membrane-bound mucins (MUC1, MUC3, and MUC4). | Human | SFTPA1 | 653509 | surfactant protein A1 | Background: Immunohistochemical studies in human lung carcinoma reported positive staining of tumor cells for surfactant protein A (SP-A), especially in peripheral airway cell carcinoma, which include bronchioloalveolar carcinoma and in some reports also papillary subtypes. Increased alveolar cell carcinoma (ACC) When compared with 10 mucinous bronchioloalveolar carcinomas (m-BAC), the latter reacted with CK7, CK20, MUC5AC, TTF-1, SP-A, CDX-2, and MUC2 in 100%, 90%, 100%, 30%, 10%, 0%, and 0% of the cases, respectively. | Human | ELMOD2 | 255520 | ELMO/CED-12 domain containing 2 | Increased alveolar cell carcinoma (ACC) | Human | MUC3B | 57876 | mucin 3B, cell surface associated | Mucinous bronchioloalveolar carcinoma (BAC) had a homogeneous pattern of mucin gene expression different from those of other types of lung adenocarcinoma, involving secreted mucins (MUC5AC, MUC5B, and MUC6) and membrane-bound mucins (MUC1, MUC3, and MUC4). From a practical point of view, the aberrant expression of MUC3 and MUC6 could serve as a diagnostic marker in the management of the mucinous type of bronchioloalveolar carcinomas. | Human | LAMP3 | 27074 | lysosomal-associated membrane protein 3 | Interestingly, human bronchioloalveolar carcinoma tumor cells, which correspond to transformed type II pneumocytes, express DC-LAMP. | Human | CADM1 | 23705 | cell adhesion molecule 1 | Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | | Human | ACTR2 | 10097 | ARP2 actin-related protein 2 homolog (yeast) | The proportion of cancer cells expressing both Arp2 and WAVE2 was significantly higher in cases with lymph-node metastasis (P = 0.0046), and significantly lower in bronchioloalveolar carcinomas (P _lt_ 0.0001). | Human | DMTF1 | 9988 | cyclin D binding myb-like transcription factor 1 | In a second step, we used an immunophosphatase technique and a specific polyclonal antibody directed against DMP1 to examine the expression of DMP1 in 59 human non-small cell lung cancer samples, including 29 squamous carcinoma, 20 adenocarcinoma, and 10 bronchioloalveolar carcinoma. | Human | DLEC1 | 9940 | deleted in lung and esophageal cancer 1 | | Human | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma. | Human | TP63 | 8626 | tumor protein p63 | rarity of p63 expression supports a nonbronchial histogenesis of bronchioloalveolar carcinoma, well-differentiated adenocarcinoma of lung, adenomatous hyperplasia and atypical adenomatous hyperplasia | Human | SLC7A5 | 8140 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | LAT1 expression may increase with the upregulation of metabolic activity and cell proliferation in high-grade atypical adenomatous hyperplasia and bronchioloalveolar carcinoma | Human | NKX2-1 | 7080 | | Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases. When compared with 10 mucinous bronchioloalveolar carcinomas (m-BAC), the latter reacted with CK7, CK20, MUC5AC, TTF-1, SP-A, CDX-2, and MUC2 in 100%, 90%, 100%, 30%, 10%, 0%, and 0% of the cases, respectively. We studied the staining patterns of bronchioloalveolar carcinoma (BAC) with antibodies to cytokeratin (CK) 7, CK20, and thyroid transcription factor-1 (TTF-1) to determine the diagnostic usefulness of this panel in differentiating BAC from metastatic adenocarcinoma in material obtained by fine-needle aspiration biopsy (FNAB) of the lung. Differential expression of cytokeratins 7 and 20 and thyroid transcription factor-1 in bronchioloalveolar carcinoma: an immunohistochemical study in fine-needle aspiration biopsy specimens. Prognostic significance of thyroid transcription factor-1 expression in both early-stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | To clarify the process and mechanisms of the development and progression of peripheral lung adenocarcinoma, we investigated the relationships among the patterns of basement membrane (BM), stromal fibrosis, and the expressions of gelatinase A and tissue inhibitor of metalloproteinases-2 (TIMP-2) in 33 lesions of atypical alveolar cell hyperplasia (AAH) and 48 lesions of lung adenocarcinoma, including 24 lesions of bronchioloalveolar carcinoma (BAC). | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | These results indicate that tumour progression in bronchopulmonary carcinomas implies a progressive disruption of the MMP/TIMP balance leading to an excess of several MMPs that act in concert in vivo. | Human | TERT | 7015 | telomerase reverse transcriptase | Increased alveolar cell carcinoma (ACC) | Human | TERF2 | 7014 | telomeric repeat binding factor 2 | Here we investigated the expressions of the mRNAs encoded by the TERF1 and TERF2 genes using in situ hybridization in surgically resected specimens [28 AAHs (11 lesions were interpreted as low-grade AAH, and 17 were interpreted as high-grade AAH) and 40 peripherally located bronchioloalveolar carcinoma (BAC). | Human | TERC | 7012 | telomerase RNA component | We investigated the expression of human telomerase RNA component (hTERC) and telomerase reverse transcriptase (hTERT) mRNA using in situ hybridization in surgically resected formalin-fixed, paraffin-embedded specimens: 29 AAHs (with 11 lesions interpreted as low-grade AAH and 18 as high-grade AAH) and 40 peripherally located nonmucinous bronchioloalveolar carcinomas (NMBACs) measuring < or = 20 mm in greatest diameter. | Human | STK11 | 6794 | serine/threonine kinase 11 | Herein, bronchioloalveolar carcinoma (BAC) of mucinous type is reported in a 22-year old male PJS patient with a novel germline frameshift insertion in exon 2 at codon 118 of the STK11 gene. | Human | SFTPC | 6440 | surfactant protein C | Increased alveolar cell carcinoma (ACC) | Human | RDX | 5962 | radixin | Real-time quantitative reverse transcription polymerase chain reaction confirmed that radixin mRNA was decreased, both in 10 early-stage bronchioloalveolar carcinomas and in 16 invasive lung adenocarcinomas, by 69% (p = 0.0002) and 82% (p < 0.0001), respectively, compared with 9 nontumor lung tissues. In conclusion, expression of radixin and moesin is down-regulated in lung adenocarcinoma, including early-stage bronchioloalveolar carcinoma. | Human | PPP2R1B | 5519 | protein phosphatase 2, regulatory subunit A, beta | | Human | PLK1 | 5347 | polo-like kinase 1 | A very low frequency of PLK transcripts was only found in bronchiolo-alveolar carcinomas. | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | |
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