Genes (78)
Species: human : 70 mouse : 8 | |
Mouse | KSR1 | 8844 | kinase suppressor of ras 1 | Hence, MT-driven mammary tumor genesis, which is signaled through src and phosphatidylinositol 3;-kinase, appears KSR1 independent, whereas v-Ha-ras-mediated skin cancer, signaled through the Raf-1/MAPK cascade, requires KSR1. | Mouse | RAB11A | 8766 | RAB11A, member RAS oncogene family | These data identify Rab11a as a novel, tumor-associated c-Fos/AP-1 target and may point to an as yet unrecognized function of Rab11a in the de-velopment of skin cancer. | Mouse | XPC | 7508 | xeroderma pigmentosum, complementation group C | Click here to display 11 evidence detail records. | Mouse | THBS2 | 7058 | thrombospondin 2 | The matricellular protein, thrombospondin-2 (TSP-2), has been shown to act as an antiangiogenesis factor in a carcinogen-induced model of skin cancer. | Mouse | KLK6 | 5653 | kallikrein-related peptidase 6 | By monitoring BSSP expression throughout experimental skin carcinogenesis we found strong constitutive expression in hyperplastic epidermis as well as in proliferatively active keratinocytes of benign and malignant skin tumors. | Mouse | JUN | 3725 | jun proto-oncogene | These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. | Mouse | ERCC6 | 2074 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | Csb(-/-) mice appear to be susceptible to UVB-induced skin cancer in contrast to the human CSB patients. In contrast to the human syndrome, CSB-deficient mice show increased susceptibility to skin cancer. | Mouse | APEX1 | 328 | APEX nuclease (multifunctional DNA repair enzyme) 1 | Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | alpha3B chain was scarcely detected in the vessels of malignant skin cancers, though the gamma2 and beta3 chains were highly expressed in the cancer cells[ laminin alpha3B ] | Human | MMP28 | 79148 | matrix metallopeptidase 28 | The aim of this study was to characterize in different types of wounds, skin cancers, and keratinocyte cultures factors that contribute to epilysin expression in vivo, as well as how and where it is induced in relation to other matrix metalloproteinases. | Human | CASP14 | 23581 | caspase 14, apoptosis-related cysteine peptidase | Expression of exogenous caspase-14 led to growth inhibition and reduced the tumorigenicity of A431 skin cancer cells | Human | IKZF2 | 22807 | IKAROS family zinc finger 2 (Helios) | Reproducibility of histopathologic diagnosis and classification of non-melanocytic skin cancer: a panel exercise in the framework of the multicenter southern European study HELIOS. | Human | CD3EAP | 10849 | CD3e molecule, epsilon associated protein | Title:Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50.|Association:Not Found|Conclusion:While it cannot be ruled out that the present findings are due to chance, the present results are consistent with previous findings that XPD Arg156Arg is a weak risk factor for basal cell carcinoma. | Human | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | The expression of HSP105 has not been studied in skin cancers. OBJECTIVES: To assess the expression of HSP105 in skin cancers including extramammary Paget disease (EMPD), cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). | Human | TP63 | 8626 | tumor protein p63 | We herein evaluated the expression profiles of p63, p53, survivin, and hTERT in usual skin cancers, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) and putative preneoplastic epidermal lesions, including actinic keratosis (AK), Bowen;s disease, and porokeratosis. The expression profile of DeltaNp73L/p73L/p51 in primary human skin cancer specimens showed that the expression of p51 was frequently lost (62%) but was detected in all normal skin samples. | Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer. We selected 11 haplotype-tagging single nucleotide polymorphisms in three DSB repair genes XRCC2, XRCC3, and LigaseIV and evaluated their associations with skin cancer risk in a nested case-control study within the Nurses; Health Study [219 melanoma, 286 squamous cell carcinoma (SCC), 300 basal cell carcinoma (BCC), and 873 controls]. Title:|Association:Not Found|Conclusion:Not Found | Human | XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | We selected 11 haplotype-tagging single nucleotide polymorphisms in three DSB repair genes XRCC2, XRCC3, and LigaseIV and evaluated their associations with skin cancer risk in a nested case-control study within the Nurses; Health Study [219 melanoma, 286 squamous cell carcinoma (SCC), 300 basal cell carcinoma (BCC), and 873 controls]. | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Genetic variation in XRCC1 and sun exposure is associated with skin cancer Data suggest that the Arg194Trp and Arg399Gln polymorphisms may be differentially associated with skin cancer risk Title:|Association:Not Found|Conclusion:Not Found | Human | XPC | 7508 | xeroderma pigmentosum, complementation group C | Click here to display 13 evidence detail records. | Human | XPA | 7507 | xeroderma pigmentosum, complementation group A | Early onset skin cancer (basal cell, squamous cell and malignant melanoma) | Human | TNFRSF4 | 7293 | tumor necrosis factor receptor superfamily, member 4 | CD30 has been used for the immunophenotyping and subclassification of cutaneous lymphomas; virtually nothing is known, however, about the expression pattern of CD134 in lymphoid skin malignancies. | Human | TP53 | 7157 | tumor protein p53 | Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer | Human | THBS2 | 7058 | thrombospondin 2 | The matricellular protein, thrombospondin-2 (TSP-2), has been shown to act as an antiangiogenesis factor in a carcinogen-induced model of skin cancer. | Human | STAT2 | 6773 | signal transducer and activator of transcription 2, 113kDa | These results support STAT2 as an important molecular target for skin cancer chemoprevention. This finding led to the hypothesis that suppressed expression of ISGF-3 proteins may lead to reduced IFN responsiveness, which in turn may contribute to skin malignancy by conferring a growth and/or survival advantage. | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Interindividual differences in the inducibility of MnSOD might account for differences in the susceptibility to develop photodermatologic disorders related to photosensitivity, photoaging, and skin cancer. No significant association between MnSOD gene polymorphism and the risk of skin cancer |
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