Genes (58)
Species:
human : 56 mouse : 2 | |
| Mouse | VEGFC | 7424 | vascular endothelial growth factor C | Vascular endothelial growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model. | | Mouse | MDK | 4192 | midkine (neurite growth-promoting factor 2) | Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. | | Human | MIR137 | 406928 | microRNA 137 | higher induced levels of miR125b and miR137 in rectal cancer are associated with worse response to the therapy | | Human | WNT10A | 80326 | wingless-type MMTV integration site family, member 10A | WNT10A mRNA was significantly up-regulated in 2 out of 8 cases of primary gastric cancer, and in 1 out of 7 cases of primary rectal cancer. | | Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | Western blot analysis showed a suppression of CXCL16 protein in rectal cancer compared to non-cancer tissue in 83% of the patients (n=23, P=0.003). Expression of CXCL16 in human rectal cancer. In this study, which is the first report on expression of the chemokine CXCL16 in human rectal cancer, CXCL16 gene and protein expression were analysed in cancer and normal adjacent tissue. | | Human | GMNN | 51053 | geminin, DNA replication inhibitor | Moreover, geminin was expressed at higher level in 56% and 58% of colon and rectal cancers, respectively, compared with the corresponding adjacent normal mucosa. | | Human | DLC1 | 10395 | deleted in liver cancer 1 | Using cancer-profiling arrays, we detected for the first time down-regulation of DLC-1 expression in renal, uterine and rectal cancers and down-regulation of DLC-2 expression in lung, ovarian, renal, breast, uterine, gastric, colon and rectal tumors. | | Human | MVP | 9961 | major vault protein | [Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance] | | Human | WNT3 | 7473 | wingless-type MMTV integration site family, member 3 | WNT3 was significantly up-regulated in a case of primary breast cancer and in a case of primary rectal cancer among various types of human primary cancers. | | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | haplotype analysis that encompasses different domains of the VDR gene might further our understanding of associations between the VDR gene and colon and rectal cancer | | Human | TYMS | 7298 | thymidylate synthetase | Ts mRNA is induced by preoperative chemoradiotherapy in both responders and nonresponders to combined modality treatment in rectal carcinoma | | Human | TP53 | 7157 | tumor protein p53 | Co-mutation of p53 and K-ras gene has neither synergic carcinogenesis-promoting effect, nor prognostic effect on rectal cancer TP53 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer | | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | EXPERIMENTAL DESIGN: Total TIMP-1 plasma levels were measured by ELISA in blood samples from two different blood donor populations from IBD patients, and preoperative samples from patients with primary colon cancer (CC), rectal cancer (RC), or breast cancer. The present study was undertaken to further validate plasma TIMP-1 as a prognostic marker in rectal cancer. Preoperative plasma from 352 rectal cancer patients were analysed using an immunoassay for TIMP-1. Title:Association between preoperative plasma levels of t inhibitor of metalloproteinases 1 and rectal cancer patient survival. a validation study.|Association:Not Found|Conclusion:Not Found The rectal cancer patients had a mean plasma TIMP-1 level of 184 microg/l (standard deviation (SD): 70 microg/l). This study showed a highly significant and independent association between preoperative plasma TIMP-1 levels and survival in rectal cancer patients, thus confirming our previous findings. | | Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with high frequency microsatellite instability We assessed the importance of mutations in the regulatory domain, located within exon 3 of CTNNB1, in 103 rectal carcinomas and correlated these data with presence of microsatellite instability, somatic frame-shift alterations of the TCF-4 gene, and APC-gene mutations in the tumors. | | Human | TCF4 | 6925 | transcription factor 4 | We assessed the importance of mutations in the regulatory domain, located within exon 3 of CTNNB1, in 103 rectal carcinomas and correlated these data with presence of microsatellite instability, somatic frame-shift alterations of the TCF-4 gene, and APC-gene mutations in the tumors. | | Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | G>A functional transition mapping the 3' untranslated region of the CXCL12 gene has been found to be under-represented among rectal cancer patients when compared to colon cancer patients | | Human | S100A4 | 6275 | S100 calcium binding protein A4 | TM is related to MTS1 gene expression deficit of rectal carcinoma, showing that MTS1 gene expression deficit or mutation may be a factor inducing transitional change adjacent to carcinoma. OBJECTIVE: To study the property of transitional mucosa (TM) adjacent to rectal carcinoma and the clinical significance of MTS1 gene deficit. [The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance] CONCLUSIONS: The inactivation of MTS1 gene is relative to the occurrence of rectal carcinoma, suggesting that the TM adjacent to rectal carcinoma possess as certain potential malignancy. METHODS: We used the immunohistochemical methods to observe the range of TM adjacent to rectal carcinoma, and the immunohistochemical method to observe the expression of MTS1 gene product on TM, using normal mucosa and carcinoma tissue as control. | | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 expression is overexpressed in the majority of rectal cancers treated with radiotherapy and likely plays a role in local relapse | | Human | PPARD | 5467 | peroxisome proliferator-activated receptor delta | The expression of PPARdelta gene in rectal cancers is not statistically different from normal mucosa | | Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | Cetuximab-based chemoradiotherapy increased PDGFRbeta levels in patients with rectal cancer | | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma. MATERIALS AND METHODS: An immunohistochemical analysis using nine monoclonal antibodies against CEA, CD15s, CD44v6, DCC, E-cadherin, EGF-R, NM23, PAI-1, and P53 was performed on paraffin sections of two matched (age, gender, UICC stage [I-III], year of operation [1982-1991]) groups of patients (n = 2 x 64) with rectal carcinoma curatively treated by surgery alone. | | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer MTHFR 677T-1298A haplotype in genomic DNA has the potential to be a predictive marker of tumor response in rectal cancer patients submitted to preoperative chemoradiotherapy | | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Overexpression of Gelatinase B is associated with advanced rectal carcinoma | | Human | MMP7 | 4316 | matrix metallopeptidase 7 (matrilysin, uterine) | E1AF mRNA overexpression correlated well with matrilysin expression in rectal cancers | | Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | Ki-67 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer |
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