Human | ARL11 | 115761 | ADP-ribosylation factor-like 11 | the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer |
Human | CAPN10 | 11132 | calpain 10 | These results indicate that some CAPN10 alleles may be exerting a protective effect on laryngeal cancer risk in the Spanish population |
Human | DEK | 7913 | DEK oncogene | DEK is overexpressed in many solid tumors such as colon cancer, larynx cancer, bladder cancer, and melanoma; the DEK promoter is bound by endogenous E2F in vivo |
Human | ZAP70 | 7535 | zeta-chain (TCR) associated protein kinase 70kDa | Both the zeta chain and the Zap 70 expression in circulating T lymphocytes are down-regulated in patients with laryngeal cancer and that these changes do not immediately return to normal after surgery |
Human | TP53 | 7157 | tumor protein p53 | The p53 level was higher than in normal larynxes, whereas laryngeal cancer presented the lowest levels |
Human | TERT | 7015 | telomerase reverse transcriptase | shRNA directed against hTERT inhibits telomerase activity through suppression of the hTERT expression in laryngeal cancer cells and that RNA interfering technology may be a promising strategy for the treatment of laryngeal cancers |
Human | RB1 | 5925 | retinoblastoma 1 | Immunohistochemical analysis of Rb protein expression in neoplastic cells made it easier to evaluate the mechanisms of cancerogenesis in laryngeal cancer and is closely related to genetic alteration in Rb locus The pRb level was higher than in normal larynxes, whereas laryngeal cancer presented the lowest levels |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cox-2 gene expression is manifest in laryngeal cancer |
Human | NBN | 4683 | nibrin | Heterozygous carriers of the I171V mutation are prone to the development of larynx cancer and display an increased risk of second tumors at other sites |
Human | MGST1 | 4257 | microsomal glutathione S-transferase 1 | Polymorphisms in microsomal glutathione s transferase is associated with laryngeal cancer |
Human | IL8 | 3576 | interleukin 8 | The researchers found a decreased risk of laryngeal cancer when a polymorphism occurs in the minor allele A promoter |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. Polymorphism is not associated with laryngeal cancer risk in Caucasians |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. |
Human | GSTM3 | 2947 | glutathione S-transferase mu 3 (brain) | Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Results suggest that GSTM1-deleted genotype may be a genetic susceptibility marker for laryngeal cancer, and that the absence of this enzyme may have a role in the development of laryngeal cancer |
Human | EPHX1 | 2052 | epoxide hydrolase 1, microsomal (xenobiotic) | Polymorphisms in microsomal epoxide hydrolase is associated with laryngeal cancer Title:Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.|Association:Not Found|Conclusion:These results on larynx cancer tend to confirm a former study on lung cancer (Cancer Lett. 173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers. |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | CpG methylation and thus loss of E-cadherin is associated with metastasising laryngeal cancer |
Human | CD44 | 960 | CD44 molecule (Indian blood group) | Immunohistochemical assessment of both Survivin and CD44v6 status in negative surgical margin may be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer |
Human | BSG | 682 | basigin (Ok blood group) | Our results suggest an importance of the direct cell-cell interaction involving EMMPRIN rather than humoral factors such as cytokines for pro-MMP-2 production and activation followed by tumor progression, invasion, and metastasis in laryngeal cancer |
Human | CCND1 | 595 | cyclin D1 | Title:Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications oftumor localization and tobacco exposure|Association:Not Found|Conclusion:Our data on gene amplification did not show any correlation with disease stage, histological tumor differentiation, recurrent disease, disease-specific survival or tumor location. However, GG870 genotype was associated with a shorter disease free interval and a reduced overall survival in laryngeal cancer patients. Moreover, this constitutes the first report of a correlation between cyclin D1 A870G polymorphism and increased susceptibility for laryngeal tumor development at the glottic region, which supports the theory of site-specific prevalence of genetic alterations. Title:|Association:Not Found|Conclusion:Not Found |
Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | silibinin induced apoptosis of laryngeal squamous carcinoma cells by a mechanism involving decreased survivin expression, which suggests the possibility that silibinin may be an effective treatment of laryngeal cancers |
Human | NAT2 | 10 | N-acetyltransferase 2 (arylamine N-acetyltransferase) | The combined effect of N-acetyltransferase 2 (NAT2) slow genotype and exposure to smoking is observed during the development of laryngeal cancer NAT2 polymorphisms may be correlated with an increased risk of larynx cancer Title:[Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]|Association:Y|Conclusion:NAT2 slow genotype increases the risk of susceptibility to laryngeal carcinoma. The combined effect of NAT2 slow genotype and exposure to smoking is observed during the development of laryngeal cancer. Title:[Restriction analysis of N-acetyltransferase 2 gene in Caucasian population of West Siberia]|Association:Not Found|Conclusion:The frequencies of these mutations did not significantly differ from the frequencies reported for Caucasian populations of other countries. In 79 patients with lung cancer, a region of the NAT2 gene that includes 29.7% of the coding sequence was analyzed for the new mutations by the RFLP analysis. No new mutations were found in this group. |
Human | NAT1 | 9 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | NAT1 polymorphisms may be correlated with an increased risk of larynx cancer |