Mouse | SSTR4 | 6754 | somatostatin receptor 4 | It is hypothesized that the effect of neuropeptide somatostatin (SS-14) on murine colonic cancer is exerted via the subtype of receptor which does not interact with CH-275 and has no or low affinity for octreotide (SSTR 4, 3 or 5?). |
Mouse | BCL2A1 | 597 | BCL2-related protein A1 | CT-26 murine colon cancer cells transfected with HSV-tk, alone or in combination with bcl-xL or bfl-1, were either grown in vitro or injected into syngeneic mice, followed by GCV administration. |
Human | MIRLET7A1 | 406881 | microRNA let-7a-1 | suggest the involvement of let-7 miRNA in the growth of colon cancer cells |
Human | B3GNT8 | 374907 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 | The cloning of a novel beta1,3-N-acetylglucosaminyltransferase that is upregulated in a human colon cancer cell line |
Human | VWA2 | 340706 | von Willebrand factor A domain containing 2 | CCSP-2 is a novel candidate for development as a diagnostic serum marker of early stage colon cancer |
Human | ENPP7 | 339221 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | Alkaline sphingomyelinase hydrolyses and inactivates PAF by a phospholipase C activity, a novel function by which it may counteract the development of intestinal inflammation and colon cancer intestinal alkaline sphingomyelinase may have a one-exon deletion in colon cancer cells |
Human | LAMA1 | 284217 | laminin, alpha 1 | Overexpression of laminin alpha1 chain in colonic cancer cells induces an increase in tumor growth. To further study the biological significance of laminin-1 (composed of alpha1, beta1 and gamma1 chains) in intestinal cell differentiation or tumorigenesis, an alpha1-laminin expression vector was introduced into the HT29 colonic cancer cells, in which laminin alpha1 chain is not expressed. |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | colon cancer-specific antigen-2 is a potential serum-based marker for colon cancer detection with high sensitivity and specificity [CCSA-2] |
Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | In contrast, SLC5A8 exon 1 proved to be aberrantly methylated in 59% of primary colon cancers and 52% of colon cancer cell lines. |
Human | FAM84A | 151354 | family with sequence similarity 84, member A | up-regulation of FAM84A may play a critical role in progression of colon cancer |
Human | AIFM3 | 150209 | apoptosis-inducing factor, mitochondrion-associated, 3 | AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function |
Human | CD109 | 135228 | CD109 molecule | Found with a mutation in 7% of colon cancers studied |
Human | MINA | 84864 | MYC induced nuclear antigen | the elevated expression of Mina53 is a characteristic feature in colon cancer |
Human | RETNLB | 84666 | resistin like beta | Supernatant from COS cells transfected with the CCRG (RETNLB) expression vector stimulated proliferation of colon cancer cells, which supports the growth factor nature of the RETNLB gene |
Human | ANTXR1 | 84168 | anthrax toxin receptor 1 | The levels of expression of TEM-8 in invasive colon cancer are linked to disease progression. |
Human | BCL2L12 | 83596 | BCL2-like 12 (proline rich) | The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression Our results suggest that BCL2L12 gene expression may represent a potential new biomarker for colon cancer |
Human | TSGA10 | 80705 | testis specific, 10 | over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers |
Human | CDK5RAP3 | 80279 | CDK5 regulatory subunit associated protein 3 | This is the first report of cdk5/p35 expression and kinase activity in colon cancer cells, which is associated with ciglitazone-induced antiproliferation in HT-29 cells |
Human | TLE6 | 79816 | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) | Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity |
Human | ANAPC1 | 64682 | anaphase promoting complex subunit 1 | Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients |
Human | MMP25 | 64386 | matrix metallopeptidase 25 | MT6-MMP may play a role in colon cancer and exhibit unique biochemical and structural properties that may regulate proteolytic function at the cell surface |
Human | GAL3ST2 | 64090 | galactose-3-O-sulfotransferase 2 | The substrate specificity of Gal3ST-2 is closely similar to those of Gal3ST activities present in human normal mucosa and adenocarcinomas, suggesting that Gal3ST-2 is the dominant Gal3ST in colon and colonic cancer. |
Human | HRH4 | 59340 | histamine receptor H4 | histamine exerts both a proproliferative and a proangiogenic effect via H2/H4 receptor activation, mediated by increasing COX-2-related PGE2 production in COX-2-expressing colon cancer cells a dramatic alteration in the distribution of histamine receptors in colon cancer |
Human | PMEPA1 | 56937 | prostate transmembrane protein, androgen induced 1 | Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases |
Human | MUC13 | 56667 | mucin 13, cell surface associated | Significant down-regulation of the MUC4, MUC12 and MUC13 genes was observed in colonic cancers compared with normal tissue, whereas MUC1 was upregulated. |