Mouse | PINK1 | 65018 | PTEN induced putative kinase 1 | BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. |
Mouse | MTA3 | 57504 | metastasis associated 1 family, member 3 | MTA3 was exclusively expressed in a subset of cells of ER-positive premalignant lesions but not in carcinomas. |
Mouse | IL22 | 50616 | interleukin 22 | Expression of interleukin-22 in murine carcinoma cells did not influence tumour growth in vivo but did improve survival of the inoculated hosts. |
Mouse | MMP24 | 10893 | matrix metallopeptidase 24 (membrane-inserted) | Specific expression of MT5-MMP was observed in the neurons but not in the glial cells when embryonal mouse carcinoma P19 cells were differentiated in vitro by retinoic acid treatment. |
Mouse | HTATIP2 | 10553 | HIV-1 Tat interactive protein 2, 30kDa | Some of these carcinomas harbor missense mutations in the Tip30 gene, which cause abnormal expression of TIP30. |
Mouse | SART3 | 9733 | squamous cell carcinoma antigen recognized by T cells 3 | Systemic immunization with the SART3(315-323) peptide and the subsequent peritumoral injection of both the SART3(315-323) peptide and OK-432 effectively induced peptide-specific and colon26 carcinoma-reactive CTLs in BALB/c mice. |
Mouse | WNT10B | 7480 | wingless-type MMTV integration site family, member 10B | Transgenic expression of Wnt1 or Wnt10b in the mouse mammary gland leads to lobuloalveolar hyperplasia with a major risk of progression to carcinoma. |
Mouse | VCL | 7414 | vinculin | However, the cytoplasmic components of adherens junctions, such as alpha-catenin, vinculin, alpha-actinin, talin, and pp125FAK, are expressed at low levels or cannot be detected in the carcinoma cells. |
Mouse | TFF1 | 7031 | trefoil factor 1 | TFF1 knockout mice developed multiple gastric adenomas and carcinomas, suggesting that TFF1 is a gastric-specific tumor-suppressor gene. |
Mouse | TRD@ | 6964 | | Well-differentiated adenocarcinoma appeared 5 months after 5 administrations of azoxymethane (10 mg/kg weight) only in a few TCRd -gene knockout mice and the frequency of the carcinoma-bearing mice was increased at 7 and 9 months after the administration. |
Mouse | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Finally, constitutive activation of Stat3 in both papillomas and squamous cell carcinomas suggest a role in both the development of autonomous growth and the progression of epithelial tumors in mouse skin. |
Mouse | SKP2 | 6502 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate. Unscheduled expression of SKP2 promoted marked overproliferation, resulting in hyperplasia, dysplasia, and low-grade carcinoma in the prostate gland. |
Mouse | SDC1 | 6382 | syndecan 1 | The ectodomain of syndecan-1 inhibited also the growth of other carcinoma cell lines, such as CarB and MCF-7, but not such inhibition was observed for contact-inhibited cell lines, including NIH 3T3 cells, NMuMG cells, and human HaCaT keratinocytes. |
Mouse | SCD | 6319 | stearoyl-CoA desaturase (delta-9-desaturase) | The expression of stearoyl-CoA desaturase and one of the unidentified genes returned to control levels in the carcinomas. |
Mouse | S100A4 | 6275 | S100 calcium binding protein A4 | The coordinated action of MT1-MMP and Mts1, which is responsible for the highly invasive properties of mesenchymal cells, may be involved in epithelial tubulogenesis and invasion of malignant carcinoma cells. |
Mouse | ROBO1 | 6091 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | Mice with a targeted deletion within one Dutt1/Robo1 allele spontaneously develop lymphomas and carcinomas in their second year of life with a 3-fold increase in incidence compared with controls: invasive lung adenocarcinomas are by far the predominant carcinoma. |
Mouse | RAG1 | 5896 | recombination activating gene 1 | UVB induction of epithelial tumors in human skin using a RAG-1 mouse xenograft model. |
Mouse | PTK2 | 5747 | protein tyrosine kinase 2 | However, the frequency of malignant conversion of papillomas into carcinomas is indistinguishable in fak +/- mice and their wild-type fak +/+ littermates, most likely because papilloma FAK protein expression is elevated to wild-type levels. |
Mouse | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Although Pms2 deficiency clearly increases adenoma formation in the Min background, histological analysis indicated no clear evidence for progression to carcinoma. |
Mouse | PRDX1 | 5052 | peroxiredoxin 1 | The malignancies include lymphomas, sarcomas and carcinomas, and are frequently associated with loss of Prdx1 expression in heterozygotes, which suggests that this protein functions as a tumour suppressor. |
Mouse | NOTCH4 | 4855 | notch 4 | RESULTS: On the basis of the expression of terminal differentiation markers, three types of neoplasm were identified: first, simple carcinomas composed exclusively of cells with a luminal phenotype are characteristic of neoplasms arising in mice transgenic for Neu, Hras, Myc, Notch4, and SV40-TAg; second, ;complex carcinomas; displaying luminal and myoepithelial differentiation are characteristic of type P tumors arising in mice transgenic for Wnt1, neoplasms arising in mice infected by the MMTV, and spontaneous adenosquamous carcinomas; and third, ;carcinomas with epithelial to mesenchymal transition (EMT); are a characteristic feature of tumor progression in Hras-, Myc-, and SV40-TAg-induced mammary neoplasms and PL/J and SJL/J mouse strains, and display de novo expression of myoepithelial and mesenchymal cell markers. |
Mouse | DRG1 | 4733 | developmentally regulated GTP binding protein 1 | In agreement, mouse skin papillomas and carcinomas also overexpressed Drg-1. |
Mouse | MST1R | 4486 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | RON, a member of the MET proto-oncogene family, has been implicated in the progression of certain epithelial cancers. |
Mouse | MFI2 | 4241 | antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 | The L49 (IgG1) monoclonal antibody binds to p97 (melanotransferrin), a tumor-selective antigen that is expressed on human melanomas and carcinomas. |
Mouse | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | [Inhibitory effect of dendritic cells induced activated cytotoxicity T lymphocyte combined with MAGE-1 nonapeptide on transplanted human hepatocyte carcinoma in nude mice] |