Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | prevalence of Nod2 polymorphisms is not increased in patients with Candida infections; unlikely to play an important role in the recognition of Candida albicans |
Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | TLR4 | 7099 | toll-like receptor 4 | TLR4 Asp299Gly/Thr399Ile polymorphisms are associated with an increased susceptibility to Candida bloodstream infections, and an increased production of IL-10 is probably involved in this effect |
Human | TLR2 | 7097 | toll-like receptor 2 | TLR2 SNP Arg753Gln results in altered cytokine release in response to Candida but not to Gram-positive sepsis |
Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | Title:|Association:Not Found|Conclusion:Not Found Title:Cost-effective genotyping of human MBL2 gene mutations using multiplex PCR.|Association:Not Found|Conclusion:MBL2 haplotypes in 359 individuals of the general Czech population were detected using this approach. The rare LYD haplotype was found in 1.1% of all alleles. |
Human | LAMB3 | 3914 | laminin, beta 3 | degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues |
Human | CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | IL10 | 3586 | interleukin 10 | Candida-specific T cell IL-10 (interleukin -10) production was markedly higher in chronic mucocutaneous candidiasis patients |
Human | IL4 | 3565 | interleukin 4 | Title:Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes.|Association:Not Found|Conclusion:Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia. |
Human | IL2RG | 3561 | interleukin 2 receptor, gamma | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | CFH | 3075 | complement factor H | the binding of Factor H and C4bp to Aspergillus spp. appears to be even stronger than to Candida spp. and different, albeit possibly nearby, binding moieties mediate this surface attachment |
Human | FGFR2 | 2263 | fibroblast growth factor receptor 2 | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | FGFR3 | 2261 | fibroblast growth factor receptor 3 | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | FGF10 | 2255 | fibroblast growth factor 10 | INFERRED, Score=800, UMLKSK CUI: C0006840 |
Human | FCGR3B | 2215 | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | Title:|Association:Not Found|Conclusion:Not Found |
Human | FCGR3A | 2214 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Title:|Association:Not Found|Conclusion:Not Found Title:Distribution of variant genotypes of Fc gamma receptor IIIa in healthy Chinese population of Zhengzhou City.|Association:Not Found|Conclusion:The distribution of Fc gamma R IIIa-158 in healthy Chinese population of Zhengzhou city was polymorphic and different from that of African Americans (AA) and Caucasian Americans (CA). |
Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | Title:Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients.|Association:Not Found|Conclusion:Not Found |
Human | DKC1 | 1736 | dyskeratosis congenita 1, dyskerin | Opportunistic infections (CMV, pneumocystis, candida) |
Human | DEFB1 | 1672 | defensin, beta 1 | Title:Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays andassociation with Candida carriage in type I diabetics and nondiabetic controls|Association:Y|Conclusion:These results indicate that genetic variations in the DEFB1 gene encoding hBD-1 may have a major role in mediating and/or contributing to susceptibility to oral infection. |
Human | CYBA | 1535 | cytochrome b-245, alpha polypeptide | Title:|Association:Not Found|Conclusion:Not Found |
Human | CD40 | 958 | CD40 molecule, TNF receptor superfamily member 5 | Absence of CD40/CD40L interactions results in increased susceptibility to disseminated infection with C. albicans through decreased NO-dependent killing of Candida by macrophages |
Human | AIRE | 326 | autoimmune regulator | Candidiasis is usually the first symptom |